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PT J
AU Aitini, E
Sempreboni, A
Aleotti, P
Zamagni, D
Cavazzini, G
Barbieri, R
Cengarle, R
Rabbi, C
Pari, F
Vivorio, B
AF Aitini, Enrico
Sempreboni, Alessia
Aleotti, Paola
Zamagni, Donatella
Cavazzini, Giovanna
Barbieri, Roberto
Cengarle, Rita
Rabbi, Carla
Pari, Franca
Vivorio, Beatrice
TI Anxiety levels in cancer patients and "life sound" experience
SO TUMORI
AB Aims and background: For the hospitalized cancer patient, time takes on a rhythm which is very different from the external reality. Based on the idea that time represents a fundamental dimension of human existence and is connected to future plans, time spent waiting and memories, we carried out this experience entitled "Life Sound" project. The objectives of the project were to experiment different and unusual ways of spending time in hospital in order to improve the quality of life of the hospitalized cancer patient, to help the patient adapt to the hospital environment, to encourage awareness of self and to give a different meaning to time spent in the hospital. In particular, we evaluated the reduction in the levels of anxiety, in psychological suffering and the improvement in communication.
Methods: We met with patients, family members, friends, volunteers and department personnel (doctors, psychologists, nurses) in a room in the Oncology and Hematology Department set aside specifically for recreation activities such as having a cup of tea while listening to music, talking, joking, listening to people's memories and celebrating birthdays, anniversaries and other special days. The study, which involved 109 patients, was carried out through the use of the questionnaire STAI-Y distributed before and after the event.
Results: The results showed a statistically significant difference in anxiety levels 2 hrs before participation (mean = 38.33) and 2 hrs after participation (mean = 34.77) in the program. This variation was also assessed based on gender, age, cancer stage, time since diagnosis and performance status but did not result in any statistically significant difference.
Conclusions: The "Life Sound" project encourages the emergence of positive feelings, of a renewed willingness to invest in personal and caring relationships, which are connected to the patient's ability to face this illness, and the opening of new channels of communication with family members and hospital staff.
SN 0300-8916
PD JAN-FEB
PY 2007
VL 93
IS 1
BP 75
EP 77
UT ISI:000247166900013
ER

PT J
AU Badger, T
Segrin, C
Dorros, SM
Meek, P
Lopez, AM
AF Badger, Terry
Segrin, Chris
Dorros, Sybilla M.
Meek, Paula
Lopez, Ana Maria
TI Depression and anxiety in women with breast cancer and their partners
SO NURSING RESEARCH
AB Background: Psychosocial interventions can improve psychological quality of life (symptoms of depression and anxiety) of both women with breast cancer and their partners, but are not offered routinely to women and their partners.
Objective: To test the. hypotheses that telephone-delivered psychosocial interventions decrease depression and anxiety in women with breast cancer and their partners.
Methods: The design of the study was a three-wave repeated measures with a between-subjects factor (treatment group). Ninety-six women and their 96 partners were assigned randomly to participate in one of three different 6-week programs: (a) telephone interpersonal counseling (TIP-C); (b) self-managed exercise; or (c) attention control (AC).
Results: The mixed-model analysis of variance for symptoms of depression among women with breast cancer revealed women's depressive symptom scores decreased over time in all groups. For anxiety, women's symptoms of anxiety decreased in the TIP-C and exercise groups over time, but not in the AC group. A parallel set of analyses was conducted on partners' depression and anxiety data, Symptoms of depression and anxiety among the partners decreased substantially over the course of the investigation. Similar to the women, partners' symptoms of anxiety decreased significantly in the TIP-C and exercise groups, but not in the AC group.
Discussion: Findings from this study support that these telephone-delivered psychosocial interventions were effective for decreasing symptoms of depression and anxiety to improve psychological quality of life when compared to an AC group.
SN 0029-6562
PD JAN-FEB
PY 2007
VL 56
IS 1
BP 44
EP 53
UT ISI:000247102400006
ER

PT J
AU Dale, W
Hemmerich, J
Meltzer, D
AF Dale, William
Hemmerich, Joshua
Meltzer, David
TI Extending the validity of the Prostate Cancer (MAX-PC) Memorial Anxiety Scale for at the time of prostate biopsy in a racially-mixed population
SO PSYCHO-ONCOLOGY
AB The Memorial Anxiety Scale for Prostate Cancer (MAX-PC) has been validated for assessing men with prostate cancer for cancer-specific anxiety. It was originally validated in a predominantly white population. The MAX-PC Prostate Cancer Anxiety Subscale (MAX-PC-PCAS) may be relevant for measuring cancer-specific anxiety in undiagnosed men at risk for prostate cancer. We assess the validity of the MAX-PC-PCAS at the time of prostate biopsy (n = 178). Questions assessed socio-demographic information, health status, patient-estimated risk of cancer, the Hospital Anxiety and Depression Scale-Anxiety Subscale (HADS-A), and the MAX-PC-PCAS. The patients' most recent PSA was recorded. Cronbach's alpha, inter-item correlations, and Pearson correlations with both the HADS-A and clinical variables were compared with the original validation sample. Our sample was younger (63.1 vs 71.1 years), had a larger fraction of African-Americans (43 vs 10%), and had higher PSAs. Cronbach's alpha was equivalent (0.91 vs 0.90), median inter-item correlation was equivalent (0.63 vs 0.61), and Pearson correlation with HADS-A was higher (0.71 vs 0.57). Anxiety levels were not correlated with PSA levels, and there were minor differences in the validation findings by race. The validity of the MAX-PC-PCAS extends to men without cancer undergoing biopsy and to African-Americans. Copyright (c) 2006 John Wiley & Sons, Ltd.
SN 1057-9249
PD MAY
PY 2007
VL 16
IS 5
BP 493
EP 498
UT ISI:000246783300011
ER

PT J
AU Midtqaard, J
Rorth, M
Steller, R
Tveteras, A
Andersen, C
Quist, M
Moller, T
Adamsen, L
AF Midtqaard, J.
Rorth, M.
Steller, R.
Tveteras, A.
Andersen, C.
Quist, M.
Moller, T.
Adamsen, L.
TI Exercise during cytostatic treatment: correlates of cancer patients' self-reported anxiety and depression
SO EJC SUPPLEMENTS
SN 1359-6349
PD OCT
PY 2005
VL 3
IS 2
SU Suppl. S
BP 369
EP 369
UT ISI:000247564801434
ER

PT J
AU Iconomou, G
Koutras, AK
Assimakopoulos, K
Mega, V
Viha, A
Iconomou, AV
Kalofonos, HP
AF Iconomou, G.
Koutras, A. K.
Assimakopoulos, K.
Mega, V.
Viha, A.
Iconomou, A. V.
Kalofonos, H. P.
TI Anxiety, depression and quality of life in cancer patients treated with chemotherapy: a prospective examination
SO EJC SUPPLEMENTS
SN 1359-6349
PD OCT
PY 2005
VL 3
IS 2
SU Suppl. S
BP 380
EP 381
UT ISI:000247564801473
ER

PT J
AU Reineke, A
Sowder, E
Gevirtz, R
AF Reineke, Anke
Sowder, Erik
Gevirtz, Richard
TI Effects of an inter-active biofeedback game on anxiety and pain in children with cancer
SO BIOLOGICAL PSYCHOLOGY
SN 0301-0511
PD MAY
PY 2007
VL 75
IS 2
BP 213
EP 214
UT ISI:000246753200047
ER

PT J
AU Cousson-Gelie, F
Bruchon-Schweitzer, M
Dilhuydy, JM
Jutand, MA
AF Cousson-Gelie, Florence
Bruchon-Schweitzer, Marilou
Dilhuydy, Jean Marie
Jutand, Marthe-Aline
TI Do anxiety, body image, social support and coping strategies predict survival in breast cancer? A ten-year follow-up study
SO PSYCHOSOMATICS
AB A longitudinal study enrolled 75 women with primary breast cancer. Before the confirmation of diagnosis, authors measured trait-anxiety and body satisfaction. Three weeks after diagnosis, coping strategies and state-anxiety were evaluated. The number of days of survival was measured 10 years after diagnosis. In Cox proportional-hazards models adjusting for severity of disease and age, high social support and low state-anxiety predicted an increased risk of death from breast cancer. A significant increased risk of death in women with low scores on the Body Image Questionnaire appeared only in the univariate model.
SN 0033-3182
PD JUN
PY 2007
VL 48
IS 3
BP 211
EP 216
UT ISI:000246210400004
ER

PT J
AU Trumbo, CW
McComas, KA
Kannaovakun, P
AF Trumbo, Craig W.
McComas, Katherine A.
Kannaovakun, Prathana
TI Cancer anxiety and the perception of risk in alarmed communities
SO RISK ANALYSIS
AB Cancer is a significant public health topic and is frequently a factor in public reactions to environmental hazards. It may be reasonable to suggest that a unique form of health anxiety exists-one specific to cancer. In this article, we explore a measure of cancer anxiety that has applicability to risk perception in the specific context of communities that are alarmed over suspect cancer rates thought to be associated with environmental hazards. A literature search was used to identify survey questions previously used to measure cancer worry, fear, anxiety, etc. A list of 24 items was employed in a mail survey sent to 30 communities in which cancer rates were under investigation (part of a broader study). An analysis of the dataset of 1,111 responses yields two versions of a cancer anxiety scale: one an additive combination of 21 items (alpha= 0.77) and the other a two-factor model consisting of nine- and four-item subscales (alpha = 0.74 and 0.69). The resulting scales are evaluated for their ability to predict perception of risk from the environmental hazards in these cases. Controlling for age, sex, and cancer status, the scales explain between 2% and 10% of risk perception (full R-2 values ranging from 0.17 to 0.24). Given the range of concepts required to model risk perception, we conclude that this measure of cancer anxiety is sufficiently reliable and robust to be recommended for use in circumstances involving hazards associated with cancer. Other uses and further development of the measure are discussed.
SN 0272-4332
PD APR
PY 2007
VL 27
IS 2
BP 337
EP 350
UT ISI:000246625600007
ER

PT J
AU Tagay, VS
Senf, W
Schopper, N
Mewes, R
Bockisch, A
Gorges, R
AF Tagay, Von Sefik
Senf, Wolfgang
Schoepper, Nicole
Mewes, Ricarda
Bockisch, Andreas
Goerges, Rainer
TI Protective factors for anxiety and depression in thyroid cancer patients
SO ZEITSCHRIFT FUR PSYCHOSOMATISCHE MEDIZIN UND PSYCHOTHERAPIE
AB Objectives: Depression and anxiety are the most common mental symptoms in patients with thyroid cancer (DTC) and have an important influence on the quality of life. The aim of the current study was to identify protective factors of depression and anxiety in DTC patients.
Methods: In a cross-sectional study 230 DTC patients were examined with Hospital Anxiety and Depression Scale (HADS-D), the Sense of Coherence Scale (SOC-13) and the Questionnaire of Social Support (F-SOZU).
Results: Depression correlated highly significantly with anxiety (r = .633, p = 0,001). Social support and sense of coherence correlated highly significantly negative with depression as well as with anxiety (both p <= 0,001). Although still significant, the correlation between age and anxiety was lower (r = -19; p <= 0,005). The TSH level as an indicator of hypothyreodism did not correlate with depression or with anxiety on a significant statistical level. Furthermore, variables such as education, religiosity and elapsed time interval since initial diagnosis were not correlated with depression and anxiety.
Discussion: Our results support the thesis that low social support and low sense of coherence enhance vulnerability to depressive and anxiety symptoms.
SN 1438-3608
PY 2007
VL 53
IS 1
BP 62
EP 74
UT ISI:000244928300007
ER

PT J
AU Sharp, DM
Walker, AA
Walker, MB
Walker, LG
AF Sharp, D. M.
Walker, A. A.
Walker, M. B.
Walker, L. G.
TI Are high levels of clinically significant anxiety and depression inevitable in the six months following the diagnosis of early breast cancer?
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD MAR
PY 2007
VL 16
IS 3
BP 272
EP 273
UT ISI:000244976700041
ER

PT J
AU Greer, J
Temel, J
Pirl, W
Lynch, T
AF Greer, J.
Temel, J.
Pirl, W.
Lynch, T.
TI Anxiety, quality of life and chemotherapy adherence among patients with advanced non-small cell lung cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD MAR
PY 2007
VL 16
IS 3
SU Suppl. S
BP S13
EP S13
UT ISI:000245044900023
ER

PT J
AU Zhang, A
Cooper, G
AF Zhang, A.
Cooper, G.
TI Recognition of depression and anxiety among colorectal cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD MAR
PY 2007
VL 16
IS 3
SU Suppl. S
BP S23
EP S24
UT ISI:000245044900042
ER

PT J
AU BrintzenhofeSzoc, KM
Levin, TT
Li, Y
Zabora, J
AF BrintzenhofeSzoc, K. M.
Levin, T. T.
Li, Y.
Zabora, J.
TI The prevalence of mixed anxiety-depression by cancer type
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD MAR
PY 2007
VL 16
IS 3
SU Suppl. S
BP S31
EP S32
UT ISI:000245044900057
ER

PT J
AU Doyle, K
Fitzgibbons, L
Rollins, P
Stringer, CA
AF Doyle, K.
Fitzgibbons, L.
Rollins, P.
Stringer, C. A.
TI Changes in depression, anxiety and psychosocial adjustment to illness following an individual intervention for women with advanced stage ovarian cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD MAR
PY 2007
VL 16
IS 3
SU Suppl. S
BP S37
EP S37
UT ISI:000245044900068
ER

PT J
AU West, L
Bauer-Wu, S
Liem, J
Powell, M
AF West, L.
Bauer-Wu, S.
Liem, J.
Powell, M.
TI Factors associated with anxiety and depression in young women recently diagnosed with breast cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD MAR
PY 2007
VL 16
IS 3
SU Suppl. S
BP S92
EP S93
UT ISI:000245044900178
ER

PT J
AU Pandey, M
Sarita, G
Devi, N
Thomas, B
Hussain, BM
Krishnan, R
AF Pandey, M.
Sarita, G.
Devi, N.
Thomas, B.
Hussain, B. M.
Krishnan, R.
TI Distress, anxiety and depression in cancer patients undergoing chemotherapy
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD MAR
PY 2007
VL 16
IS 3
SU Suppl. S
BP S98
EP S98
UT ISI:000245044900189
ER

PT J
AU Pressley, Z
DeLong, L
Curiel-Lewandrowski, C
Chen, S
AF Pressley, Zakiya
DeLong, Laura
Curiel-Lewandrowski, Clara
Chen, Suephy
TI Quality of life and cancer anxiety impact of total body digital photography in patients with atypical mole syndrome
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
SN 0190-9622
PD FEB
PY 2007
VL 56
IS 2
SU Suppl. S
BP AB144
EP AB144
UT ISI:000243972801116
ER

PT J
AU Chauhan, D
Sharpe, L
Clarke, S
Thewes, B
Rickard, J
AF Chauhan, D.
Sharpe, L.
Clarke, S.
Thewes, B.
Rickard, J.
TI Using different screening modalities to assess for anxiety and depression amongst cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S105
EP S106
UT ISI:000242413900251
ER

PT J
AU Alvarado, MC
AF Alvarado, M. C.
TI Anxiety in children with cancer and their parents
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S157
EP S157
UT ISI:000242413900370
ER

PT J
AU Grassi, L
Sabato, S
Rossi, E
Marmai, L
Biancosino, B
Gatti, M
AF Grassi, L.
Sabato, S.
Rossi, E.
Marmai, L.
Biancosino, B.
Gatti, M.
TI Depressive and anxiety disorders among cancer patients: Screening methods hy using the distress thermometer compared to the ICD-10
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S162
EP S162
UT ISI:000242413900382
ER

PT J
AU Cankurtaran, ES
Ozalp, E
Soygur, H
Turhan, L
AF Cankurtaran, E. S.
Ozalp, E.
Soygur, H.
Turhan, L.
TI The effect of mirtazapine on depression, anxiety symptoms and quality of life in cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S192
EP S193
UT ISI:000242413900452
ER

PT J
AU Ciaramella, A
Lucente, F
Paroli, M
Poli, P
AF Ciaramella, A.
Lucente, F.
Paroli, M.
Poli, P.
TI Differences in pain perception between patients with and without cancer. Role of anxiety and depression
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S200
EP S201
UT ISI:000242413900471
ER

PT J
AU Cousson-Gelie, F
Bruchon-Schweitzer, M
Dilhuydy, JM
Jutand, MA
AF Cousson-Gelie, F.
Bruchon-Schweitzer, M.
Dilhuydy, J. M.
Jutand, M. A.
TI Impact of social support, anxiety and coping on survival after breast cancer: A ten year followup study
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S213
EP S214
UT ISI:000242413900503
ER

PT J
AU Cross, LJ
Clover, KA
Adams, CA
Utram, SC
Ponman, LK
AF Cross, L. J.
Clover, K. A.
Adams, C. A.
Utram, S. C.
Ponman, L. K.
TI A multidisciplinary pilot study to screen for anxiety and distress in cancer patients when a head immobilization device is used for radiotherapy treatment
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S214
EP S214
UT ISI:000242413900504
ER

PT J
AU Geinitz, H
Thamm, R
Keller, M
Molls, M
Zimmermann, F
AF Geinitz, H.
Thamm, R.
Keller, M.
Molls, M.
Zimmermann, F.
TI Longitudinal evaluation of anxiety, depression and quality of life in patients with conformal radiation therapy (CRT) for prostate cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S246
EP S247
UT ISI:000242413901025
ER

PT J
AU Gorayeb, R
Matthes, HTZ
Andrade, JM
AF Gorayeb, R.
Matthes, H. T. Z.
Andrade, J. M.
TI Anxiety, depression and level of knowledge in breast and gynaecological cancer patients in a public University Hospital in Brazil
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S252
EP S253
UT ISI:000242413901039
ER

PT J
AU Lopez Soler, C
Hernandez, S
Fernandez, V
AF Lopez Soler, C.
Hernandez, S.
Fernandez, V
TI Affective and anxiety problems of childhood cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S259
EP S260
UT ISI:000242413901056
ER

PT J
AU Helmes, AW
Vogel, BA
Bengel, J
AF Helmes, A. W.
Vogel, B. A.
Bengel, J.
TI Predictors of anxiety and depression in breast cancer patients: Physician-patient communication or coping?
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S264
EP S265
UT ISI:000242413901067
ER

PT J
AU Hill, KA
Warner, E
Esplen, MJ
Butler, K
Bieenwald, R
AF Hill, K. A.
Warner, E.
Esplen, M. J.
Butler, K.
Bieenwald, R.
TI Distress and breast cancer anxiety among BRCA mutation carriers participating in MRI-based screening
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S267
EP S267
UT ISI:000242413901073
ER

PT J
AU Yamashita, M
Saeki, T
Inoue, S
Mantani, T
Okamura, H
AF Yamashita, M.
Saeki, T.
Inoue, S.
Mantani, T.
Okamura, H.
TI Family functioning as a predictor of depression and anxiety in breast cancer survivors: 3-year prospective study
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S279
EP S279
UT ISI:000242413901101
ER

PT J
AU Lienard, A
Merckaert, I
Libert, Y
Marchal, S
Razavi, D
AF Lienard, A.
Merckaert, I
Libert, Y.
Marchal, S.
Razavi, D.
TI Factors that influence cancer patients' anxiety following a medical consultation. Impact of a communication skills training program for physicians
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S308
EP S308
UT ISI:000242413901169
ER

PT J
AU Mehnert, A
Lehmann, C
Koch, U
Schulte, T
AF Mehnert, A.
Lehmann, C.
Koch, U.
Schulte, T.
TI Presence of prostate cancer related anxiety and psychosocial distress in patients during rehabilitative follow-up care
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S322
EP S322
UT ISI:000242413901201
ER

PT J
AU Neumann, M
Pfaff, H
AF Neumann, M.
Pfaff, H.
TI Sex and empathy of physicians and affection of nurses can improve patients' anxiety level in first months after cancer diagnosis - An explorative, retrospective study in patients with bronchial, oesophagus, colorectal, breast, prostate and skin cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S346
EP S347
UT ISI:000242413901258
ER

PT J
AU Pandey, M
Devi, N
Ramdas, K
Krishnan, R
Thomas, BC
AF Pandey, M.
Devi, N.
Ramdas, K.
Krishnan, R.
Thomas, B. C.
TI Distress, anxiety and depression in patients with head neck cancer undergoing treatment with curative intent
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S359
EP S359
UT ISI:000242413901288
ER

PT J
AU Pikunas, JDKA
Springer, C
AF Pikunas, J. D. K. A.
Springer, C.
TI Anxiety and depression at the point of cancer diagnosis and its relationship to coping
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S369
EP S369
UT ISI:000242413901312
ER

PT J
AU Reis, JC
Lucas, HM
AF Reis, J. C.
Lucas, H. M.
TI Illness representation and levels of quality of life, anxiety and depression in patients with prostate cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S380
EP S380
UT ISI:000242413901339
ER

PT J
AU Schillani, G
Malagoli, M
Tuveri, G
Giraldi, T
AF Schillani, G.
Malagoli, M.
Tuveri, G.
Giraldi, T.
TI Anxiety, depression and mental adaptation in cancer patients - Role of serotonin transporter and monoamine oxidase polymorphism
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S399
EP S399
UT ISI:000242413901384
ER

PT J
AU Snoj, Z
Primic Aakelj, M
Milan, L
AF Snoj, Z.
Primic Aakelj, M.
Milan, L.
TI Depression and anxiety in Slovenian breast cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S416
EP S416
UT ISI:000242413901424
ER

PT J
AU Walker, MB
Walker, AA
Walker, LG
Sharp, DM
AF Walker, M. B.
Walker, A. A.
Walker, L. G.
Sharp, D. M.
TI What happens to anxiety and depression in women with early breast cancer accessing an integrated oncology health service?
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD OCT
PY 2006
VL 15
IS 2
SU Suppl. S
BP S452
EP S452
UT ISI:000242413901508
ER

PT J
AU Stephenson, NLN
Swanson, M
Dalton, J
Keefe, FJ
Engelke, M
AF Stephenson, Nancy L. N.
Swanson, Melvin
Dalton, JoAnn
Keefe, Francis J.
Engelke, Martha
TI Partner-delivered reflexology: Effects on cancer pain and anxiety (vol 34, pg 127, 2007)
SO ONCOLOGY NURSING FORUM
SN 0190-535X
PD MAR
PY 2007
VL 34
IS 2
BP 280
EP 280
UT ISI:000244949700012
ER

PT J
AU Frick, E
Tyroller, M
Panzer, M
AF Frick, E.
Tyroller, M.
Panzer, M.
TI Anxiety, depression and quality of life of cancer patients undergoing radiation therapy: a cross-sectional study in a community hospital outpatient centre
SO EUROPEAN JOURNAL OF CANCER CARE
AB The purpose of the present study is to determine the impact of illness characteristics and psychopathological comorbidity on the quality of life (QoL) of radio-oncological patients in health-related and individual dimensions. Sixty-three of 93 eligible patients (40 women and 23 men) were included in the study during their radiation therapy visit to an outpatient centre annexed to a community hospital in Southern Bavaria, Germany. In a semi-structured interview, we elicited individually relevant life domains rated by the patients according to the 'Schedule for the Evaluation of Individual Quality of Life - Direct Weighting'. In addition, the participants completed the 'European Organization for Research and Treatment of Cancer (EORTC) QoL Questionnaire Core 30' and the 'Hospital Anxiety and Depression Scale'. We also assessed the demand for psychotherapy and utilization of psycho-oncological services. In total, 9.5% of the examined patients suffer from clinically relevant anxiety and/or depression [total Hospital Anxiety and Depression Scale (HADS) score > 19]. There was a weak positive correlation between Karnofsky's Performance Status and QoL. Anxiety and depression were significantly correlated with impaired QoL, especially with impaired individual QoL. There was no association between psychopathological comorbidity and the requirement for psycho-oncological support. Conversely, patients who report difficulties in accepting help had a significantly lower QoL. Psychopathological comorbidity has a considerable influence on QoL of patients undergoing radiotherapy. Measuring the individual QoL appears as an adapted needs assessment and helps the psychotherapist in focusing on the patient's problems and desires. Furthermore, the patient's QoL is a main target in providing or planning mental health care in non-university oncological services.
SN 0961-5423
PD MAR
PY 2007
VL 16
IS 2
BP 130
EP 136
UT ISI:000244942500004
ER

PT J
AU Takahashi, K
Ida, I
Kumano, H
Oshima, A
Yuuki, N
Aihara, M
Sato, H
Majima, T
Yonemura, K
Fukuda, M
Oriuchi, N
Amanuma, M
Endo, K
Matsuda, H
Mikuni, M
AF Takahashi, K.
Ida, I.
Kumano, H.
Oshima, A.
Yuuki, N.
Aihara, M.
Sato, H.
Majima, T.
Yonemura, K.
Fukuda, M.
Oriuchi, N.
Amanuma, M.
Endo, K.
Matsuda, H.
Mikuni, M.
TI Brain metabolic changes associated with the onset of depression and anxiety in cancer patients
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
SN 1323-1316
PD APR
PY 2007
VL 61
IS 2
BP S7
EP S7
UT ISI:000244600300040
ER

PT J
AU Stephenson, NLN
Swanson, M
Dalton, J
Keefe, FJ
Engelke, M
AF Stephenson, Nancy L. N.
Swanson, Melvin
Dalton, JoAnn
Keefe, Frances J.
Engelke, Martha
TI Partner-delivered reflexology: Effects on cancer pain and anxiety
SO ONCOLOGY NURSING FORUM
AB Purpose/Objectives: To compare the effects of partner-delivered foot reflexology and usual care plus attention on patients' perceived pain and anxiety.
Design: The experimental pretest/post-test design included patient-partner dyads randomly assigned to an experimental or control group.
Setting: Four hospitals in the southeastern United States.
Sample: 42 experimental and 44 control subjects comprised 86 dyads of patients with metastatic cancer and their partners, representing 16 different types of cancer; 23% of patients had lung cancer, followed by breast, colorectal, and head and neck cancer and lymphoma. The subjects had a mean age of 58.3 years, 51% were female, 66% had a high school education or less, and 58% were Caucasian, 40% were African American, and 1% were Filipino.
Methods: The intervention included a 15-to 30-minute teaching session on foot reflexology to the partner by a certified reflexologist, an optional 15-to 30-minute foot reflexology session for the partner, and a 30-minute, partner-delivered foot reflexology intervention for the patient. The control group received a 30-minute reading session from their partners.
Main Research Variables: Pain and anxiety. Findings: Following the initial partner-delivered foot reflexology, patients experienced a significant decrease in pain intensity and anxiety.
Conclusions: A nurse reflexologist taught partners how to perform reflexology on patients with metastatic cancer pain in the hospital, resulting in an immediate decrease in pain intensity and anxiety; minimal changes were seen in the control group, who received usual care plus attention.
Implications for Nursing: Hospitals could have qualified professionals offer reflexology as a complementary therapy and teach interested partners the modality.
SN 0190-535X
PD JAN
PY 2007
VL 34
IS 1
BP 127
EP 132
UT ISI:000243441000022
ER

PT J
AU Schoen, M
Roth, A
Nelson, C
Bhaskaran, V
AF Schoen, Mary
Roth, Andrew
Nelson, Christian
Bhaskaran, Vidhya
TI Anxiety and depression in prostate cancer survivors, postprostatectomy.
SO ONCOLOGY NURSING FORUM
SN 0190-535X
PD JAN
PY 2007
VL 34
IS 1
BP 172
EP 173
UT ISI:000243441000041
ER

PT J
AU Wilson, KG
Chochinov, HM
Skirko, MG
Allard, P
Chary, S
Gagnon, PR
Macmillan, K
De Luca, M
O'Shea, F
Kuhl, D
Fainsinger, RL
Clinch, JJ
AF Wilson, Keith G.
Chochinov, Harvey Max
Skirko, Merika Graham
Allard, Pierre
Chary, Srini
Gagnon, Pierre R.
Macmillan, Karen
De Luca, Marina
O'Shea, Fiona
Kuhl, David
Fainsinger, Robin L.
Clinch, Jennifer J.
TI Depression and anxiety disorders in palliative cancer care
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
AB Depression and anxiety disorders are thought to be common in palliative cancer care, but there is inconsistent evidence regarding their relevance for other aspects of quality of life. In the Canadian National Palliative Care Survey, semi-structured interviews assessing depression and anxiety disorders were administered to 381 patients who were receiving palliative care for cancer. There were 212 women and 169 men, with a median survival of, 63 days. We found that 93 participants (24.4 %, 95 % confidence interval= 20.2-29.0) fulfilled Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnostic criteria for at least one anxiety or depressive disorder (20.7% prevalence of depressive disorders, 13.9% prevalence of anxiety disorders). The most frequent individual diagnosis was major depression (13.1%, 95% confidence interval = 9.9-16.9). Comorbidity was common, with 10.2% of participants meeting criteria for more than one disorder. Those diagnosed with a disorder were significantly younger than other participants (P = 0.002). They also had lower performance status (P = 0.017), smaller social networks (P = 0.008), and less participation in organized religious services (P = 0.007). In addition, they reported more severe distress on 14 of 18 physical symptoms, social concerns, and existential issues. Of those with a disorder, 39.8% were being treated, with antidepressant medication, and 66.7% bad been prescribed a benzodiazepine. In conclusion, it appears that, de/nession, and anxiety disorders are indeed common among patients receiving palliative care. The disorders contribute to a greatly diminished quality of life among people who are dying of cancer.
SN 0885-3924
PD FEB
PY 2007
VL 33
IS 2
BP 118
EP 129
UT ISI:000244268800004
ER

PT J
AU Andrews, A
Rosenbaum, EH
Garlan, R
Siegal, A
Hirschberger, N
Butler, LD
Esserman, L
Spiegel, D
AF Andrews, A.
Rosenbaum, E. H.
Garlan, R.
Siegal, A.
Hirschberger, N.
Butler, L. D.
Esserman, L.
Spiegel, D.
TI The life tape project: a psychosocial intervention for cancer patients and their families to increase communication and support, and reduce isolation and existential anxiety.
SO BREAST CANCER RESEARCH AND TREATMENT
SN 0167-6806
PY 2006
VL 100
SU Suppl. 1
BP S99
EP S99
UT ISI:000242047100287
ER

PT J
AU Wilkinson, SM
Love, SB
Westcombe, AM
Gambles, MA
Burgess, CC
Cargill, A
Young, T
Maher, EJ
Ramirez, AJ
AF Wilkinson, Susie M.
Love, Sharon B.
Westcombe, Alex M.
Gambles, Maureen A.
Burgess, Caroline C.
Cargill, Anna
Young, Teresa
Maher, E. Jane
Ramirez, Amanda J.
TI Effectiveness of aromatherapy massage in the management of anxiety and depression in patients with cancer: A multicenter randomized controlled trial
SO JOURNAL OF CLINICAL ONCOLOGY
AB Purpose
To test the effectiveness of supplementing usual supportive care with aromatherapy massage in the management of anxiety and depression in cancer patients through a pragmatic two-arm randomized controlled trial in four United Kingdom cancer centers and a hospice.
Patients and Methods
Two hundred eighty-eight cancer patients, referred to complementary therapy services with clinical anxiety and/or depression, were allocated randomly to a course of aromatherapy massage or usual supportive care alone.
Results
Patients who received aromatherapy massage had no significant improvement in clinical anxiety and/or depression compared with those receiving usual care at 10 weeks postrandomization ( odds ratio [ OR], 1.3; 95% CI, 0.9 to 1.7; P =.1), but did at 6 weeks postrandomization ( OR, 1.4; 95% CI, 1.1 to 1.9; P =.01). Patients receiving aromatherapy massage also described greater improvement in self-reported anxiety at both 6 and 10 weeks postrandomization ( OR, 3.4; 95% CI, 0.2 to 6.7; P =.04 and OR, 3.4; 95% CI, 0.2 to 6.6; P =.04), respectively.
Conclusion
Aromatherapy massage does not appear to confer benefit on cancer patients' anxiety and/or depression in the long-term, but is associated with clinically important benefit up to 2 weeks after the intervention.
SN 0732-183X
PD FEB 10
PY 2007
VL 25
IS 5
BP 532
EP 539
UT ISI:000244176000012
ER

PT J
AU Filipovic, BR
Filipovic, BF
Kerkez, M
Milinic, N
Randelovic, T
AF Filipovic, Branislav R.
Filipovic, Branka F.
Kerkez, Mirko
Milinic, Nikola
Randelovic, Tomislav
TI Depression and anxiety levels in therapy-naive patients with inflammatory bowel disease and cancer of the colon
SO WORLD JOURNAL OF GASTROENTEROLOGY
AB AIM: To assess whether depression and anxiety are more expressed in patients with the first episode of inflammatory bowel disease (IBD) than in individuals with newly discovered cancer of the colon (CCa).
METHODS: A total of 32 patients with IBD including 13 males and 19 females, aged 27 to 74, and 30 patients with CCa including 20 males and 10 females, aged 39-78, underwent a structured interview, which comprised Hamilton's Depression Rating Inventory, Hamilton's Anxiety Rating Inventory and Paykel's Stressful Events Rating Scale.
RESULTS: Patients of the IBD group expressed both depression and anxiety. Depressive mood, sense of guilt, psychomotor retardation and somatic anxiety were also more pronounced in IBD patients. The discriminant function analysis revealed the total depressive score was of high importance for the classification of a newly diagnosed patient into one of the groups.
CONCLUSION: Newly diagnosed patients with IBD have higher levels of depression and anxiety. Moreover, a psychiatrist in the treatment team is advisable from the beginning. (c) 2007 The WJG Press. All rights reserved.
SN 1007-9327
PD JAN 21
PY 2007
VL 13
IS 3
BP 438
EP 443
UT ISI:000243613900017
ER

PT J
AU Bekher, OA
Slonimskaya, EM
Kupriyanova, IE
AF Bekher, O. A.
Slonimskaya, E. M.
Kupriyanova, I. E.
TI Level of anxiety in breast cancer women
SO NEURO-ONCOLOGY
SN 1522-8517
PD OCT
PY 2006
VL 8
IS 4
BP 360
EP 361
UT ISI:000240877300271
ER

PT J
AU Tsutsumi, S
Yamaki, S
Yamaguchi, S
Asao, T
Kuwano, H
AF Tsutsumi, Soichi
Yamaki, Sayaka
Yamaguchi, Satoru
Asao, Takayuki
Kuwano, Hiroyuki
TI Anxiety in outpatients receiving chemotherapy for solid cancer
SO HEPATO-GASTROENTEROLOGY
AB Background/Aims: We conducted this prospective study to assess the anxiety in outpatients receiving chemotherapy for solid cancers.
Methodology: Patients were eligible if they were receiving chemotherapy for solid cancer in an outpatient setting, had a life expectancy of more than 6 months, and were able to complete self-administered questionnaires. The State-Trait Anxiety Inventory (STAI) was used to measure the anxiety levels.
Results: From January to December 2004, 119 patients were recruited, and, of these, 114 completed the questionnaires. Their median age was 60.6 years, and the male-to-female ratio was 1.04:1. Of the 114 patients, 36 had breast cancer, 35, colorectal cancer, 23, gastric cancer, 8, esophageal cancer, 5, non-small-cell cancer, 4, pancreatic cancer, and 3, liver cancer. The state- and trait-anxiety levels were higher for women (p=0.019). Age did not influence the trait-anxiety level, but the state-anxiety levels of younger patients were higher. The periods of chemotherapy raised the state and trait-anxiety levels (p=0.023 and 0.015, respectively). No statistically significant differences were observed according to the type of cancer.
Conclusions: The anxiety levels of outpatients with solid cancer receiving chemotherapy were significantly high. Having access to such information will help oncologists provide appropriate support to their patients.
SN 0172-6390
PD NOV-DEC
PY 2006
VL 53
IS 72
BP 828
EP 830
UT ISI:000242306400005
ER

PT J
AU Dell'Agostino, K
Fiumano, M
Fusco, O
Malugani, F
Berardi, E
Menatti, E
Bartolini, A
AF Dell'Agostino, K.
Fiumano, M.
Fusco, O.
Malugani, F.
Berardi, E.
Menatti, E.
Bartolini, A.
TI Anxiety/depression screening in cancer patient by Zung evaluation form
SO ANNALS OF ONCOLOGY
SN 0923-7534
PY 2006
VL 17
SU Suppl. 11
BP XI34
EP XI34
UT ISI:000242379800128
ER

PT J
AU Seo, PH
Sloane, R
Ingram, SS
Misra, D
Clipp, EC
Montana, GS
Cohen, HJ
AF Seo, P. H.
Sloane, R.
Ingram, S. S.
Misra, D.
Clipp, E. C.
Montana, G. S.
Cohen, H. J.
TI The relationship between older cancer survivors' reports of depression, anxiety and pain to health providers' findings and mortality.
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUN 20
PY 2006
VL 24
IS 18
PN Part 1 Suppl. S
BP 492S
EP 492S
UT ISI:000239009403269
ER

PT J
AU Pasquini, M
Biondi, M
Costantini, A
Cairoli, F
Ferrarese, G
Picardi, A
Sternberg, C
AF Pasquini, M.
Biondi, M.
Costantini, A.
Cairoli, F.
Ferrarese, G.
Picardi, A.
Sternberg, C.
TI Detection and treatment of depressive and anxiety disorders among cancer patients: Feasibility and preliminary findings from a liaison service in an oncology division
SO DEPRESSION AND ANXIETY
AB Our aim in this observational study was to evaluate the feasibility of a multiphasic screening project for the detection and treatment of mood and anxiety disorders among cancer patients in a natural setting. One hundred sixty-five patients with cancer, consecutively admitted to the Oncology Division of San Camillo-Forlanini Hospital, were recruited to the study. All patients had solid tumors; the majority of them were. colon, breast, and lung cancers. All patients completed the Hospital Anxiety and Depression Scale (HADS). Patients screened as positive were administered the following instruments by a psychiatrist. the Structured Clinical Interview for DSM-IV (SCID-I), the Beck Depression Inventory (BDI), the Hamilton Anxiety Rating Scale (HARS), and a validated scale for the rapid dimensional assessment of psychopathology (SVARAD). The BDI, HARS, and SVARAD were administered again at 4 and 10 weeks to all treated patients. Out of 45 patients administered the SCID-I, 37 had a mood or anxiety disorder. Adjustment disorders were identified in 20 patients, depressive disorders in 14, and anxiety disorders in three patients. Most patients were prescribed psychotropic medications: mirtazapine was prescribed to 15 patients, citalopram to 13 patients, and escitalopram to four patients. A significant improvement in symptoms of depression and anxiety was observed on all measures (P <.001). Although the design of the study prevents any firm conclusions about effectiveness, this study suggests that including psychiatric expertise in an oncology division is feasible and may lead to improved detection and treatment of psychiatric disorders among cancer patients. Further randomized trials are needed to elaborate on our findings.
SN 1091-4269
PY 2006
VL 23
IS 7
BP 441
EP 448
UT ISI:000241907600010
ER

PT J
AU Cankurtaran, ES
Soygur, AH
Ozalp, E
Turhan, L
AF Cankurtaran, E. S.
Soygur, A. H.
Ozalp, E.
Turhan, L.
TI Mirtazapine versus tricyclic antidepressants for the treatment of depression, anxiety and distressing symptoms of cancer
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
SN 0924-977X
PD SEP
PY 2006
VL 16
SU Suppl. 4
BP S324
EP S325
UT ISI:000240771301022
ER

PT J
AU Robb, KA
Miles, A
Campbell, J
Evans, P
Wardle, J
AF Robb, Kathryn A.
Miles, Anne
Campbell, John
Evans, Philip
Wardle, Jane
TI Can cancer risk information raise awareness without increasing anxiety? A randomized trial
SO PREVENTIVE MEDICINE
AB Objective. Promoting public awareness of cancer risk factors is an important public health goal, but there is concern that it could heighten anxiety. This study examined the impact of mailed information about colorectal cancer on awareness of risk factors, emotional well-being, and interest in attending screening in a population not previously exposed to screening.
Method. Individuals (3,185) aged 45-66 years registered with general practitioners in South-West England in 2004 were randomized to (1) control group (no information), (2) information on colorectal cancer risk factors, or (3) information on risk factors and colorectal screening. All participants were sent a questionnaire assessing knowledge, anxiety, worry about colorectal cancer, and interest in screening.
Results. Questionnaires (1,945; 61%) were returned. As expected, participants receiving information had significantly greater knowledge than the control group. Anxiety scores were in the normal range and neither anxiety nor worry about cancer differed significantly between the groups. Ninety-three percent of respondents indicated they would be interested in screening, with equally high levels across groups.
Conclusion. This study suggests that information leaflets can promote knowledge of cancer risk factors without increasing anxiety. Low-cost educational materials have the potential to contribute to public engagement with health promotion and disease prevention. (c) 2006 Elsevier Inc. All rights reserved.
SN 0091-7435
PD SEP
PY 2006
VL 43
IS 3
BP 187
EP 190
UT ISI:000240876000007
ER

PT J
AU Antoni, MH
Wimberly, SR
Lechner, SC
Kazi, A
Sifre, T
Urcuyo, KR
Phillips, K
Smith, RG
Petronis, VM
Guellati, S
Wells, KA
Blomberg, B
Carver, CS
AF Antoni, Michael H.
Wimberly, Sarah R.
Lechner, Suzanne C.
Kazi, Aisha
Sifre, Tammy
Urcuyo, Kenya R.
Phillips, Kristin
Smith, Roselyn G.
Petronis, Vida M.
Guellati, Sophie
Wells, Kurrie A.
Blomberg, Bonnie
Carver, Charles S.
TI Reduction of cancer-specific thought intrusions and anxiety symptoms with a stress management intervention among women undergoing treatment for breast cancer
SO AMERICAN JOURNAL OF PSYCHIATRY
AB Objective: After surgery for breast cancer, many women experience anxiety relating to the cancer that can adversely affect quality of life and emotional functioning during the year postsurgery. Symptoms such as intrusive thoughts may be ameliorated during this period with a structured, group-based cognitive behavior intervention.
Method: A 10-week group cognitive behavior stress management intervention that included anxiety reduction ( relaxation training), cognitive restructuring, and coping skills training was tested among 199 women newly treated for stage 0-111 breast cancer. They were then followed for 1 year after recruitment.
Results: The intervention reduced reports of thought intrusion, interviewer ratings of anxiety, and emotional distress across 1 year significantly more than was seen with the control condition. The beneficial effects were maintained well past the completion of adjuvant therapy.
Conclusions: Structured, group-based cognitive behavior stress management may ameliorate cancer-related anxiety during active medical treatment for breast cancer and for 1 year following treatment. Group-based cognitive behavior stress management is a clinically useful adjunct to offer to women treated for breast cancer.
SN 0002-953X
PD OCT
PY 2006
VL 163
IS 10
BP 1791
EP 1797
UT ISI:000240906800024
ER

PT J
AU Lienard, A
Merckaert, I
Libert, Y
Delvaux, N
Marchal, S
Boniver, J
Etienne, AM
Klastersky, J
Reynaert, C
Scalliet, P
Slachmuylder, JL
Razavi, D
AF Lienard, A.
Merckaert, I.
Libert, Y.
Delvaux, N.
Marchal, S.
Boniver, J.
Etienne, A. -M.
Klastersky, J.
Reynaert, C.
Scalliet, P.
Slachmuylder, J. -L.
Razavi, D.
TI Factors that influence cancer patients' anxiety following a medical consultation: impact of a communication skills training programme for physicians
SO ANNALS OF ONCOLOGY
AB Background: No study has yet assessed the impact of physicians' skills acquisition after a communication skills training programme on the evolution of patients' anxiety following a medical consultation. This study aimed to compare the impact, on patients' anxiety, of a basic communication skills training programme (BT) and the same programme consolidated by consolidation workshops (CW), and to investigate physicians' communication variables associated with patients' anxiety.
Patients and methods: Physicians, after attending the BT, were randomly assigned to CW or to a waiting list. The control group was not a non-intervention group. Consultations with a cancer patient were recorded. Patients' anxiety was assessed with the State Trait Anxiety Inventory before and after a consultation. Communication skills were analysed according to the Cancer Research Campaign Workshop Evaluation Manual.
Results: No statistically significant change over time and between groups was observed. Mixed-effects modelling showed that a decrease in patients' anxiety was linked with screening questions (P = 0.045), physicians' satisfaction about support given (P = 0.004) and with patients' distress (P < 0.001). An increase in anxiety was linked with breaking bad news (P = 0.050) and with supportive skills (P = 0.013). No impact of the training programme was observed.
Conclusions: This study shows the influence of some communication skills on the evolution of patients' anxiety. Physicians should be aware of these influences.
SN 0923-7534
PD SEP
PY 2006
VL 17
IS 9
BP 1450
EP 1458
UT ISI:000240587900017
ER

PT J
AU Osborn, RL
Demoncada, AC
Feuerstein, M
AF Osborn, Robyn L.
Demoncada, Angelique C.
Feuerstein, Michael
TI Psychosocial interventions for depression, anxiety, and quality of life in cancer survivors: Meta-analyses
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
AB Objective: The purpose of this meta-analysis was to investigate the effects of cognitive behavioral therapy (CBT) and patient education (PE) on commonly reported problems (depression, anxiety, pain, physical functioning, and quality of life (QOL)) in adult cancer survivors. Methods: Meta analyses of randomized controlled trials of CBT and PE were conducted. MEDLINE, PSYCHINFO and the Cochrane Database were searched from 1993-2004. The effects of individual versus group interventions and short (< 8 months) versus long (> 8 months) term follow up are also reported. Results: Fifteen studies met quality criteria. The sample size was 1,492 adult cancer survivors with an age range of 18-84. 790 were randomly assigned to intervention groups and 702 to control groups. CBT varied in duration from 4 weekly one-hour sessions to 55 weekly two-hour sessions. PE ranged from a single 20-minute session to 6 weekly one-hour sessions. Follow up ranged from I week to 14 months. CBT was effective for depression (ES = 1.2; 95% Cl = 0.22-2.19), anxiety (ES = 1.99; 95% Cl = 0.69-3.31), and QOL (ES = 0.91; 95% CI = 0.38-1.44). QOL was improved at both short and (ES = 1.45, 95% CI =.43-2.47) and long term (ES =.26; 95% Cl =.06-.46) follow up. PE was not related to improved outcomes. Conclusions: CBT is related to short-term effects on depression and anxiety and both short and long term effects on QOL. Individual interventions were more effective than group. Various CBT approaches provided in an individual format can assist cancer survivors in reducing emotional distress and improving quality of life.
SN 0091-2174
PY 2006
VL 36
IS 1
BP 13
EP 34
UT ISI:000239498300002
ER

PT J
AU Kahan, Z
Varga, K
Dudas, R
Nyari, T
Thurzo, L
AF Kahan, Zsuzsanna
Varga, Katalin
Dudas, Rita
Nyari, Tibor
Thurzo, Laszlo
TI Collaborative/active participation per se does not decrease anxiety in breast cancer
SO PATHOLOGY & ONCOLOGY RESEARCH
AB The information needs of breast cancer patients on their disease, its treatment, the prognosis, and their attitude to decision-making concerning treatment were assessed. One hundred and fifty early and 45 metastatic breast cancer patients were recruited into the study. The amount of information and role in the treatment decision-making process preferred by the patient were independently estimated by the patient and the oncologist, using questionnaires. Information was provided in accordance with the wishes of the patient as perceived by the physician. Test of anxiety was performed before, and one week after the consultation. Most of the patients claimed to anticipate the provision of extensive information and an active role in the decision-making, but real interest during the consultation was found less frequently. The post-consultation anxiety test revealed a significant decrease in situational anxiety; this was not related to the patient's information needs or her attitude to the decision-making concerning treatment. Our study demonstrates that a significant decrease in anxiety may be achieved via a consultation tailored to the needs of the patient. Loading the patient with information and involvement in the decision regarding therapy as much as the patient seems comfortable with lowers distress.
SN 1219-4956
PY 2006
VL 12
IS 2
BP 93
EP 101
UT ISI:000239140500006
ER

PT J
AU Rogers, SN
Rajlawat, B
Goru, J
Lowe, D
Humphris, GM
AF Rogers, Simon N.
Rajlawat, Bijaya
Goru, Janaki
Lowe, Derek
Humphris, Gerry M.
TI Comparison of the domains of anxiety and mood of the University of Washington Head and Neck Cancer Questionnaire (UW-QOL v4) with the CES-D and HADS
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
AB Background. Version 4 of the University of Washington Head and Neck Cancer Questionnaire (UW-QOLv4) includes items on mood and anxiety. The aim of this study was to compare the responses to these single items with the Centre for Epidemiology Studies Depression Scale (CES-D) and the Hospital Anxiety Depression Scale (HADS).
Methods. A cross-sectional postal survey was undertaken in April 2003. The survey was composed of all patients treated for oral and oropharyngeal squamous cell carcinoma between 1992 and 2002 who were alive and disease free.
Results. We distributed 306 questionnaires; there were 197 replies (65%) from 110 male and 87 female patients. Most patients reported relatively little depression, with 170 of 190 (89%) reporting a HADS depression score of less than 11. Similarly, most patients were not anxious, with 158 of 183 (86%) reporting a HADS anxiety score of less than 11. UW-QOL mood, UW-QOL anxiety, HADS anxiety, HADS depression, and CES-D scores were all moderately intercorrelated (Spearman correlations from 0.39-0.68 ignoring the signs, all p < .001). The UW-COIL mood correlated with the scores and "case-ness" categories of the HADS depression and CES-D scales, whereas the UW-QOL anxiety correlated with the scores and "case-ness" of the HADS anxiety.
Conclusions. Questions on mood and anxiety can help identify significant psychological 'morbidity, taking a score of less than 75 for UW-QOL mood and less than 70 for UW-OOL anxiety. This could be used to trigger formal psychological assessment and with a view to possible therapeutic intervention. (c) 2006 Wiley Periodicals, Inc.
SN 1043-3074
PD AUG
PY 2006
VL 28
IS 8
BP 697
EP 704
UT ISI:000239179900005
ER

PT J
AU Roth, A
Nelson, CJ
Rosenfeld, B
Warshowski, A
O'Shea, N
Scher, H
Holland, JC
Slovin, S
Curley-Smart, T
Reynolds, T
Breitbart, W
TI Assessing anxiety in men with prostate cancer: Further data on the reliability and validity of the Memorial Anxiety Scale for Prostate Cancer (MAX-PC)
SO PSYCHOSOMATICS
AB Identifying which men with prostate cancer might benefit from mental health treatment has proven to be a challenging task. The authors developed the Memorial Anxiety Scale for Prostate Cancer (MAX-PC) in order to facilitate the identification of prostate cancer-related anxiety. A revised version of this scale was tested in a more clinically varied population. Ambulatory men with prostate cancer (N = 367) completed a baseline assessment packet that included the MAXPC and other psychosocial questionnaires. The MAX-PC showed high internal consistency and concurrent and discriminant validity. Factor analysis identified three distinct factors for the MAX-PC that corresponded to the intended subscales (General Prostate Cancer Anxiety, PSA (prostate-specific antigen) Anxiety, and Fear of Recurrence). PSA levels were not correlated with anxiety overall; however, anxiety was significantly higher among patients whose PSA levels were changing (i.e., rising, falling, and unstable), versus those with stable PSA levels. Also, in a multivariate analysis, the change in PSA levels was a significant predictor of MAX-PC scores, but not Hospital Anxiety and Depression Scale (HADS) scores. These results indicate that the MAX-PC is a valid and reliable measure of anxiety that assesses aspects of anxiety unique to men with prostate cancer and it may provide a more sensitive measure of anxiety than the HADS for this population.
SN 0033-3182
PD JUL-AUG
PY 2006
VL 47
IS 4
BP 340
EP 347
UT ISI:000238767900011
ER

PT J
AU Tagay, S
Herpertz, S
Langkafel, M
Erim, Y
Bockisch, A
Senf, W
Gorges, R
TI Health-related quality of life, depression and anxiety in thyroid cancer patients
SO QUALITY OF LIFE RESEARCH
AB Objectives: We examined the relationships among physical complaints, health-related quality of life (HRQL), anxiety and depression in differentiated thyroid cancer (DTC) patients under short-term hypothyroidism.
Methods: We conducted a cross-sectional study in 136 patients hypothyroid on thyroid hormone withdrawal (THW) hospitalized for radioiodine administration. Patients were assessed using Short Form SF-36 (SF-36), Hospital Anxiety and Depression Scale (HADS), Profile of Mood States (POMS), Beck Depression Inventory (BDI), and physical complaints.
Results: Compared to the German general population, hypothyroid patients had significantly impaired HRQL. Surprisingly, the prevalence of anxiety (62.5%), but not depression (17.9%) was much higher in hypothyroid DTC patients than in the general population. In multivariate analysis, depression and age were independently associated with the physical health score (R-2 = 0.21), but only psychological variables (depression, mood disturbance, and anxiety) were associated with the mental health score (R-2 = 0.43), on the SF-36 HRQL instrument.
Conclusions: HRQL is severely impaired in DTC patients under short-term hypothyroidism. As potential predictors of generic HRQL impairment, depression, anxiety, and mood disturbance could be used to preselect the patients most needing psychiatric care. The high frequency of anxiety should be considered in the aftercare of thyroid cancer patients.
SN 0962-9343
PD MAY
PY 2006
VL 15
IS 4
BP 695
EP 703
UT ISI:000237489100012
ER

PT J
AU Hedstrom, M
Kreuger, A
Ljungman, G
Nygren, P
von Essen, L
TI Accuracy of assessment of distress, anxiety, and depression by physicians and nurses in adolescents recently diagnosed with cancer
SO PEDIATRIC BLOOD & CANCER
AB Background. As staff members prioritize medical resources for patients, it is imperative to find Out whether their assessments of patients' health status agree with patients' assessments. The degree to which physicians and nurses can identify the distress, anxiety, and depression experienced by adolescents recently diagnosed with cancer was examined here. Procedure. Adolescents undergoing chemotherapy (13-19 years, n = 53), physicians (n 48), and nurses (n=53) completed a structured telephone interview, 4-8 weeks after diagnosis or relapse, investigating disease and treatment-related distress, anxiety, and depression. Results. The accuracy of staff ratings of physical distress could be considered acceptable. However, problems of a psychosocial nature, which were frequently overestimated, were difficult for staff to identify. Staff underestimated the distress caused by mucositis and worry about missing school more than they overestimated distress. These aspects were some of the most prevalent and overall worst according to the adolescents. Both physicians and nurses overestimated levels of anxiety and depression. Nurses tended to show higher sensitivity than physicians for distress related to psychosocial aspects of distress, while physicians tended to show higher accuracy than nurses for physical distress. Conclusions. Staff was reasonably accurate at identifying physical distress in adolescents recently diagnosed with cancer whereas psychosocial problems were generally poorly identified. Thus, the use of staff ratings as a "test" to guide specific Support seems problematic. Considering that the accuracy of staff ratings outside a research study is probably lower, identification of and action taken on adolescent problems in relation to cancer diagnosis and treatment need to rely on direct communication.
SN 1545-5009
PD JUN
PY 2006
VL 46
IS 7
BP 773
EP 779
UT ISI:000237304100013
ER

PT J
AU Norberg, AL
Lindblad, F
Boman, KK
TI Support-seeking, perceived support, and anxiety in mothers and fathers after children's cancer treatment
SO PSYCHO-ONCOLOGY
AB The objective was to examine the relationships between anxiety, the seeking of social support as a coping strategy, and perceived social support among mothers (n = 103) and fathers (n = 8 1) of children with successfully completed treatment for cancer. Assessments were done using self-report instruments. The mediating effect of perceived support on the relationship between social support-seeking and anxiety was evaluated through path analysis, and comparisons were done in order to evaluate effects of gender.
For mothers and fathers alike, a positive relationship of moderate strength between support-seeking and perceived support was found. Anxiety was negatively related to support-seeking (mothers r = -0.22, p = 0.025; fathers r = -0.21, p = 0.063) as well as perceived support (mothers r = -0.55, p < 0.001; fathers r = -0.41 p < 0.001), although the relationship for support-seeking was weak. The path analysis showed that perceived support only to a minor extent could strengthen this association. The significance of support-seeking and perceived support was stronger for mothers than for fathers, as regards their association with anxiety. However, the patterns of interrelations were similar for mothers and fathers. In conclusion, parents' subjectively perceived support appears to be more important for anxiety regulation than their support-seeking coping. In clinical practice, individual variation should be acknowledged, and presumptions of general gender differences avoided. Copyright (c) 2005 John Wiley & Sons, Ltd.
SN 1057-9249
PD APR
PY 2006
VL 15
IS 4
BP 335
EP 343
UT ISI:000236993400006
ER

PT J
AU Jones, RB
Pearson, J
Cawsey, AJ
Bental, D
Barrett, A
White, J
White, CA
Gilmour, WH
TI Effect of different forms of information produced for cancer patients on their use of the information, social support, and anxiety: randomised trial
SO BRITISH MEDICAL JOURNAL
AB Objective To explore the hypothesis that different methods of selecting and printing information for cancer patients could improve emotional support by affecting interaction with others, and so lead to improved psychological wellbeing.
Design Randomised trial with eight groups (three factors, 2x2x2). Data collected at recruitment and three month follow-up.
Participants 400 patients starting radiotherapy, Of whom 325 with breast or prostate cancer and complete anxiety and depression data were included in the analysis.
Interventions Printed booklets: half had only general information from CancerBACUP about each patients cancer and half had personalised information from the patient's medical record plus selected general information; half were composed of information chosen interactively by the patient and half were produced automatically with a larger volume of material; mid half had additional advice on anxiety management.
Main outcome measures Patients' views of the information, use of their booklets with others; change in reported social support; change in anxiety and depression.
Results The larger booklets produced automatically were more likely to be found useful and to tell patients something new and less likely to be seen as too limited than the booklets produced interactively, but they were also more likely to overwhelm some patients. Personalised booklets were more likely than general booklets to tell patients something new. There was no difference in patients' perceived understanding of their cancer by any of the intervention factors. Patients with personalised information were more likely to show their booklets to others and to think it helped in discussing their, cancer or its treatment. There were no major differences in social support, anxiety, or depression by an), intervention factors.
Conclusions Patients were more likely to show personalised information to their confidants than general information. Further research is needed into the effects of sharing information on patients' social Support and anxiety.
SN 0959-8146
PD APR 22
PY 2006
VL 332
IS 7547
BP 942
EP 946A
UT ISI:000237143900016
ER

PT J
AU McCoubrie, R
Davies, A
TI Is there a correlation between spirituality and anxiety and depression in patients with advanced cancer?
SO SUPPORTIVE CARE IN CANCER
AB Aims and objectives: To establish whether there is a correlation between spirituality and anxiety and depression in patients with advanced cancer. Patients and methods: Patients with a diagnosis of cancer at St. Peter's day hospice in Bristol were asked to complete three questionnaires to assess anxiety, depression and spirituality. Informed consent was obtained. Anxiety and depression are indicated by the Hospital Anxiety and Depression Scale score, and spirituality is indicated by scores on the Spiritual Well-Being Scale (SWBS) and the Royal Free Interview for Spiritual and Religious Beliefs. As will be explained, religion and spirituality are generally recognised as having different meanings-religion entailing a relationship with a higher being, while spirituality can be thought of in terms of meaning and purpose in life. Results: Eighty-five complete data sets were obtained. A significant negative correlation was found between both anxiety and depression scores and overall spiritual well-being scores (p < 0.0001). When the SWBS subscale scores were analysed individually, a significant negative correlation was found between the existential well-being scores and the anxiety and depression scores (p < 0.001). However, no correlation was found between the religious well-being scores and anxiety or depression. Conclusions: This study found a significant negative correlation between spirituality (in particular, the existential aspect) and anxiety and depression in patients with advanced cancer. Religious well-being and strength of belief had no impact on psychological well-being in this study.
SN 0941-4355
PD APR
PY 2006
VL 14
IS 4
BP 379
EP 385
UT ISI:000236983200012
ER

PT J
AU Korfage, IJ
Esskink-Bot, ML
Janssens, ACJW
Schroder, FH
de Koning, HJ
TI Anxiety and depression after prostate cancer diagnosis and treatment: 5-year follow-up
SO BRITISH JOURNAL OF CANCER
AB To document anxiety and depression from pretreatment till 5-year follow-up in 299 men with localized prostate cancer. To assess, if baseline scores were predictive for anxiety and depression at 1-year follow-up. Respondents completed four assessments (pretreatment, at 6 and 12 months, and at 5-year follow-up) on anxiety, depression and mental health. Respondents were subdivided according to therapy (prostatectomy or radiotherapy) and high vs low-anxiety. Pretreatment 28% of all patients were classified as 'high-anxiety'; their average anxiety scores decreased significantly post-treatment, that is towards less anxiety. At all assessments, high-anxiety men treated by prostatectomy reported less depression than high-anxiety men treated by radiotherapy. Of men treated by radiotherapy, 27% reported clinical significant levels of depression while 20% is expected in a general population. The improvement in mental health at 6-months follow-up was statistically significant and clinically meaningful in all respondent groups. Sensitivity of anxiety at baseline as a screening tool was 71% for anxiety and 60% for symptoms of depression. We recommend clinicians to attempt early detection of patients at risk of high levels of anxiety and depression after prostate cancer diagnosis since prevalence is high. STAI-State can be a useful screening tool but needs further development.
SN 0007-0920
PD APR 24
PY 2006
VL 94
IS 8
BP 1093
EP 1098
UT ISI:000236910300002
ER

PT J
AU Rimes, KA
Salkovskis, PA
Jones, L
Lucassen, AA
TI Applying a cognitive-behavioral model of health anxiety in a cancer genetics service
SO HEALTH PSYCHOLOGY
AB A cognitive-behavioral model of health anxiety was used to investigate reactions to genetic counseling for cancer. Participants (N = 218) were asked to complete a questionnaire beforehand and 6 months later. There was an overall decrease in levels of cancer-related anxiety, although 24% of participants showed increased cancer-related anxiety at follow-up. People who had a general tendency to worry about their health reported more cancer-related anxiety than those who did not at both time points. This health-anxious group also showed a postcounseling anxiety reduction, whereas the others showed no significant change. Participants with breast or ovarian cancer in their family were more anxious than participants with colon cancer in their family. Preexisting beliefs were significant predictors of anxiety, consistent with a cognitive-behavioral approach.
SN 0278-6133
PD MAR
PY 2006
VL 25
IS 2
BP 171
EP 180
UT ISI:000236681200005
ER

PT J
AU Saevarsdottir, T
Fridriksdottir, N
Gunnarsdottir, S
TI Quality of life, symptoms of anxiety and depression, and rehabilitation needs of people receiving chemotherapy for cancer at the initiation of chemotherapy and three months later.
SO ONCOLOGY NURSING FORUM
SN 0190-535X
PD MAR
PY 2006
VL 33
IS 2
BP 469
EP 469
UT ISI:000236697600285
ER

PT J
AU [Anon]
TI Trait anxiety predicts fatigue in women with early stage breast cancer
SO EJC SUPPLEMENTS
SN 1359-6349
PD MAR
PY 2006
VL 4
IS 2
BP 91
EP 92
UT ISI:000236447700183
ER

PT J
AU Mehnert, A
Cao, P
Graefen, M
Huland, H
Koch, U
TI Prevalence of post-traumatic stress disorder, anxiety and depression in patients with prostate cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD FEB
PY 2006
VL 15
IS 1
SU Suppl. S
BP S66
EP S66
UT ISI:000235659000125
ER

PT J
AU Greer, JA
Zhang, BH
Vanderwerker, LC
Prigerson, HG
TI Prevalence and correlates of anxiety in patients with advanced cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD FEB
PY 2006
VL 15
IS 1
SU Suppl. S
BP S81
EP S82
UT ISI:000235659000152
ER

PT J
AU Thomas, BC
Devi, N
Sarita, GP
Rita, K
Ramdas, K
Hussain, BM
Rejnish, R
Pandey, M
TI Reliability & validity of the Malayalam hospital anxiety & depression scale (HADS) in cancer patients
SO INDIAN JOURNAL OF MEDICAL RESEARCH
AB Background & objectives: The hospital anxiety and depression scale (HADS) has been widely used on cancer patients as an indicator of psychological morbidity. Though the scale has been used in India, no reports are available on translation of HADS in any Indian language and testing the reliability. The present study describes the translation process of HADS into Malayalam and testing its reliability and validity on psychological morbidity in cancer patients.
Methods: The English version of the HADS was translated into Malayalam and was used in this study. The questionnaire was administered to 240 cancer patients and statistical analysis was carried out using Chronbach's alpha to test the internal consistancy of the HADS scale while confirmatory factor analysis was carried out using principal axis factoring with equimax rotation and Kaiser Normalization to test its construct validity.
Results: The Cronbach's alpha was found to be 0.81 for the HADS anxiety subscale, 0.71 for the BADS depression subscale, and 0.85 for RADS tool. Confirmatory factor analysis (CFA) indicated two depression items (i.e., enjoyment and anhedonia) loading onto the anxiety subscale. Clinical caseness for anxiety was observed in 8 per cent, while 11 per cent of the patients had borderline mood disorder. Clinical caseness for depression was identified in 7.6 and 13 per cent of patients were found to have borderline mood disturbances.
Interpretation & conclusion: This preliminary validation study of the Malayalam version of the HADS showed it as an acceptable, and reliable measure of psychological morbidity among cancer patients. The prevalence of anxiety and depression in Indian population was low and enjoyment and anhedonia might present as anxiety initially.
SN 0971-5916
PD NOV
PY 2005
VL 122
IS 5
BP 395
EP 399
UT ISI:000235017900007
ER

PT J
AU Tagay, S
Herpertz, S
Langkafel, M
Erim, Y
Freudenberg, L
Schopper, N
Bockisch, A
Senf, W
Gorges, R
TI Health-related quality of life, anxiety and depression in thyroid cancer patients under short-term hypothyroidism and TSH-suppressive levothyroxine treatment
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
AB Objective: Very few previous studies have compared the degree of health-related quality of life (HRQL), depression and anxiety of differentiated thyroid cancer patients (DTC) under short-term hypothyroidism and levothyroxine treatment.
Methods: Using patient-completed instruments, we examined the frequency of physical complaints, HRQL, anxiety and depression in 130 DTC patients hospitalized for radioiodine therapy or whole-body diagnostics (age 52 years, female 71%) under short-term hypothyroidism (4 weeks of levothyroxine withdrawal; DTC-H) and in 100 DTC out-patients under TSH-suppressive doses of levothyroxine subsequent to radioiodine therapy (DTC-L; age 49 years, female 81%).
Results: Compared with the German general population, DTC-H as well as DTC-L patients had significantly impaired HRQL. Notably, the decrease in HRQL was significantly higher in DTC-H than in DTC-L patients. Surprisingly, the prevalence of anxiety (44.6%) but not depression (17.7%) was much higher in the DTC-H patients than in the general population. In contrast to expectations, similar results for anxiety (44.0%) and depression (17.6%) were observed in the DTC-L patients.
Conclusions: This mounting evidence suggests that a consistent pattern of HRQL impairment is experienced by patients with DTC. The high frequency of anxiety and the significantly reduced HRQL should be considered in the aftercare of DTC patients.
SN 0804-4643
PD DEC
PY 2005
VL 153
IS 6
BP 755
EP 763
UT ISI:000234216100005
ER

PT J
AU Gothelf, D
Rubinstein, M
Shemesh, E
Miller, O
Farbstein, I
Klein, A
Weizman, A
Apter, A
Yaniv, I
TI Pilot study: Fluvoxamine treatment for depression and anxiety disorders in children and adolescents with cancer
SO JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
AB Objective: To evaluate the safety, tolerability, and benefit of fluvoxamine for the treatment of major depressive disorder or anxiety disorders in children and adolescents with cancer. Method: The study was conducted from 2001 to 2004 at a pediatric hematology-oncology center. Fifteen children and adolescents with cancer were treated with fluvoxamine 100 mg/day in an open prospective 8-week trial. Safety and tolerability were evaluated at baseline and at weeks 4 and 8 by blood tests and the Side Effects Checklist. Clinical benefit was assessed with the Clinical Global ImpressionsImprovement, the Children's Depression Rating Scale-Revised, and the Pediatric Anxiety Rating Scale. Results: Fluvoxamine was well tolerated by all subjects. Psychiatric symptoms improved significantly. Conclusions: In this open trial, fluvoxamine appeared to be well tolerated and was associated with a promising reduction in the depression and anxiety symptoms of pediatric patients with cancer.
SN 0890-8567
PD DEC
PY 2005
VL 44
IS 12
BP 1258
EP 1262
UT ISI:000233470000007
ER

PT J
AU Bez, Y
Topcuoglu, V
Kemal, KM
Demir, A
Turkeri, L
TI Comparison of depression, anxiety and quality of life in prostate cancer patients with and without sexual dysfunctions
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
SN 0022-3999
PD JUL
PY 2005
VL 59
IS 1
BP 23
EP 24
UT ISI:000232433800011
ER

PT J
AU Ozkan, M
Kurt, A
TI The comparison of anxiety and depression in patients with cancer pain and non-cancer chronic pain
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
SN 0022-3999
PD JUL
PY 2005
VL 59
IS 1
BP 42
EP 42
UT ISI:000232433800084
ER

PT J
AU Ozkan, S
Sipahi, B
TI Evaluation of anxiety, depression expressive motions of mothers with children who has cancer from a psychosocial perspective
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
SN 0022-3999
PD JUL
PY 2005
VL 59
IS 1
BP 43
EP 43
UT ISI:000232433800086
ER

PT J
AU Monti, DA
Mago, R
Kunkel, EJS
TI Depression, cognition, and anxiety among postmenopausal women with breast cancer
SO PSYCHIATRIC SERVICES
SN 1075-2730
PD NOV
PY 2005
VL 56
IS 11
BP 1353
EP 1355
UT ISI:000233118200004
ER

PT J
AU Asanami, C
Tei, K
Totsuka, Y
Katakura, A
Shibahara, T
Ueda, M
Yamashita, T
Nagai, I
Hiratsuka, H
Sakano, Y
TI Psychological impact of disfigurement on depression and anxiety in patients with head and neck cancer
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
SN 0022-3999
PD JUN
PY 2005
VL 58
IS 6
SU Suppl. S
BP S49
EP S49
UT ISI:000232375200221
ER

PT J
AU Vernejoux, J
Grandon, L
Izadifar, A
Decouvelaere, A
Josse, M
Prevot, S
Taytard, A
TI Quality of life and anxiety-depression in lung cancer patients: Preliminary results of a French multi-professional interview for diagnosis disclosure (MIDD)
SO LUNG CANCER
SN 0169-5002
PD JUL
PY 2005
VL 49
SU Suppl. 2
BP S343
EP S344
UT ISI:000231307802330
ER

PT J
AU Skarstein, J
Bjelland, I
Dahl, AA
Laading, J
Fossa, SD
TI Is there an association between haemoglobin, depression, and anxiety in cancer patients?
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
AB Objective: The aim of this study was to examine the association between haemoglobin levels, anxiety disorder, and depression in cancer patients. Methods: Cancer patients attending The Norwegian Radium Hospital (NRH) rated themselves on the Hospital Anxiety and Depression Scale (HADS). Five hundred thirty-two patients also had valid measurements of haemoglobin at the same time. The associations between tertile baemoglobin levels (7.0-12.3 g/dl, 12.4-13.8 g/dl, 13.9-17.1 g/dl) and HADS-defined anxiety disorder and depression were analysed by logistic regression. Results: HADS-defined depression was identified in 116 cases (22%) and anxiety disorder in 149 (28%). The haemoglobin levels of the lower and middle tertiles were associated with depression (OR=3.85, 95% CI: 2.06-7.21, and OR=2.45, 95% CI: 1.25-4.81, respectively). Adjustment for covariates did not change the association significantly. No association between haemoglobin and anxiety disorder was found. Conclusion: In cancer patients, the risk of depression increases with decreasing haemoglobin levels. This should be taken into account when treatment of anaemic or depressed cancer patients is decided upon. (c) 2005 Elsevier Inc. All rights reserved.
SN 0022-3999
PD JUN
PY 2005
VL 58
IS 6
BP 477
EP 483
UT ISI:000232258500002
ER

PT J
AU Matsushita, T
Matsushima, E
Maruyama, M
TI Anxiety and depression of patients with digestive cancer
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
AB This study sought to characterize the psychological status of digestive cancer patients, and to investigate the relationship between psychological characteristics and clinical factors. Subjects were 85 inpatients scheduled to undergo surgery for digestive cancer and 26 control patients. The Japanese versions of Hospital Anxiety and Depression Scale (HADS) and Zung's Self Rating Depression Scale (SDS) were administered for all subjects before surgery, before discharge, and 6 months after discharge. Changes in HADS and SDS scores across the three examination days for three groups of subjects (advanced-phase, early phase, and control groups) were compared. The mean scores of anxiety and depression were significantly higher in the advanced-phase group than in the other two groups. Examination day showed a significant effect on depression; depression increased from before surgery to before discharge, and did not return to the preoperative level at 6 months after discharge, but no significant effect on anxiety. As for the relationship between psychological trends and clinical factors, anxiety in the 'middle age' and 'chemotherapy' groups was more severe than in the 'elderly' and 'no chemotherapy' groups. Depression in the 'medical treatment equipment', 'chemotherapy', and 'long-term hospitalization' groups was more severe than in the 'no equipment', 'no chemotherapy', and 'standard-term hospitalization' groups. These results suggest that we should pay careful attention to cancer patients undergoing surgery, especially young patients who are constantly at risk of anxiety, and assess their depression taking into account their disease and treatment conditions, especially after the time when their discharge is determined.
SN 1323-1316
PD OCT
PY 2005
VL 59
IS 5
BP 576
EP 583
UT ISI:000232230900011
ER

PT J
AU Boscaglia, N
Clarke, DM
Jobling, TW
Quinn, MA
TI The contribution of spirituality and spiritual coping to anxiety and depression in women with a recent diagnosis of gynecological cancer
SO INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
AB The objective of this study was to determine whether, after accounting for illness and demographic variables, spiritual involvement and beliefs and positive and negative spiritual coping could account for any of the variation in anxiety and depression among women within 1 year's diagnosis of gynecological cancer (GC). One hundred patients from outpatient GC clinics at two Melbourne-based hospitals completed a brief structured interview and self-report measures of anxiety, depression, spirituality, and spiritual coping. Using two sequential regression analyses, we found that younger women with more advanced disease, who used more negative spiritual coping, had a greater tendency towards depression and that the use of negative spiritual coping was associated with greater anxiety scores. Although not statistically significant, patients with lower levels of generalized spirituality also tended to be more depressed. The site of disease and phase of treatment were not predictive of either anxiety or depression. We conclude that spirituality and spiritual coping are important to women with GC and that health professionals in the area should consider these issues.
SN 1048-891X
PD SEP-OCT
PY 2005
VL 15
IS 5
BP 755
EP 761
UT ISI:000231798800007
ER

PT J
AU Mystakidou, K
Tsilika, E
Parpa, E
Katsouda, E
Galanos, A
Vlahos, L
TI Assessment of anxiety and depression in advanced cancer patients and their relationship with quality of life
SO QUALITY OF LIFE RESEARCH
AB The growing interest in the mental health and quality of life of cancer patients, has been the major reason for conducting this study. The aims were to compare advanced cancer patients' responses to Hospital Anxiety and Depression (HAD) scale with those to European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30, version 3.0), as well as the impact of quality of life dimensions (as measured by EORTC QLQ-C30) on the levels of anxiety and depression. The analysis, conducted in 120 advanced cancer patients, showed that the most significant associations were found between emotional functioning and HAD-T (total sum of scores) (r=-0.747; p < 0.0005), HAD-A (anxiety) (r=-0.725; p < 0.0005) and HAD-D (depression) (r=-0.553; p < 0.0005). In the prediction of HAD-T, the contribution of physical, emotional, role, and social functioning along with nausea-vomiting, dyspnea, sleep disturbance and gender is high. For anxiety, the predictor variables were physical, role, cognitive, emotional, and social functioning, followed by dyspnea, sleep disturbance, and appetite loss, while depression was predicted by physical, role, emotional, and social functioning, the symptoms of nausea-vomiting, pain, sleep disturbance, constipation, as well as the variables of age, gender, anticancer treatment and performance status. Concluding, psychological morbidity, in this patient population, was predominantly predicted by the emotional functioning dimension of EORTC QLQ-C30.
SN 0962-9343
PD OCT
PY 2005
VL 14
IS 8
BP 1825
EP 1833
UT ISI:000231807200004
ER

PT J
AU Jehn, CF
Kuhnhardt, DM
Possinger, K
Flath, B
TI Plasma IL-6 and HPA-axis function in depression and anxiety in patients with cancer.
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUN 1
PY 2005
VL 23
IS 16
PN Part 1 Suppl. S
BP 737S
EP 737S
UT ISI:000230326604577
ER

PT J
AU Vora, A
Parikh, PM
Shanthi, N
Pai, VR
Prasad, N
Goswami, S
Shah, S
TI Role of Hospital Anxiety & Depression scale in reducing need of a formal psychiatric referral in cancer patients.
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUN 1
PY 2005
VL 23
IS 16
PN Part 1 Suppl. S
BP 738S
EP 738S
UT ISI:000230326604581
ER

PT J
AU Mertens, WC
Katz, D
Quinlan, M
Hoffman, D
Carr, C
Makari-Judson, G
TI Are oncologists effective in modifying patient-perceived breast cancer risk and associated anxiety?
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUN 1
PY 2005
VL 23
IS 16
PN Part 1 Suppl. S
BP 768S
EP 768S
UT ISI:000230326605120
ER

PT J
AU Smith, F
Kandahari, M
Tomita, D
Green, J
Dansey, R
Crawford, J
TI Neutropenia and anxiety in advanced non-small cell lung cancer (NSCLC) patients: initial report of a randomized controlled trial using pegfilgrastim to reduce neutropenia complications.
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUN 1
PY 2005
VL 23
IS 16
PN Part 1 Suppl. S
BP 772S
EP 772S
UT ISI:000230326605133
ER

PT J
AU Bylow, KA
Dale, W
Gupta, S
Lacy, M
Rodin, M
TI Anxiety changes following initiation of treatment in older breast cancer (BrCa) patients.
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUN 1
PY 2005
VL 23
IS 16
PN Part 1 Suppl. S
BP 793S
EP 793S
UT ISI:000230326605220
ER

PT J
AU Williams, SA
Schreier, AM
TI The role of education in managing fatigue, anxiety, and sleep disorders in women undergoing chemotherapy for breast cancer
SO APPLIED NURSING RESEARCH
AB This study examined the effect of informational audiotapes on patients' self-care behaviors (SCBs) to manage chemotherapy side effects of fatigue, anxiety, and sleep disturbance. Seventy-one women with breast cancer participated. Thirty-three received audiotapes on SCBs to manage side effects. Three telephone interviews were conducted. Overall, women who received education demonstrated more SCBs, a wider range of SCBs, increased use of SCBs over time, and less anxiety. Nursing time for education in busy clinics is minimal. Patient anxiety in the clinic environment interferes with learning. Audiotapes are an effective tool for use at home, providing for teaching and reinforcement of patient education. (c) 2005 Elsevier Inc. All rights reserved.
SN 0897-1897
PD AUG
PY 2005
VL 18
IS 3
BP 138
EP 147
UT ISI:000231165900003
ER

PT J
AU Thamm, R
Geinitz, H
Zimmermann, F
Scholz, C
Winkler, C
Prause, N
Keller, M
Busch, R
Molls, M
TI Longitudinal evaluation of fatigue, anxiety and depression in conformal radiation therapy (CRT) of prostate cancer
SO STRAHLENTHERAPIE UND ONKOLOGIE
SN 0179-7158
PD MAY
PY 2005
VL 181
SU Suppl. 1
BP 73
EP 74
UT ISI:000229590600263
ER

PT J
AU Pieterse, AH
Ausems, MGEM
Van Dulmen, AM
Beemer, FA
Bensing, JM
TI Initial cancer genetic counseling consultation: Change in counselees' cognitions and anxiety, and association with addressing their needs and preferences
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
AB The fulfillment of counselees' expectations in cancer genetic counseling and how this affects the outcome of counseling have received little attention so far. This study investigates how the initial consultation influences counselees' cognitions and anxiety, whether counselors address counselees' prior needs and preferences during the visit, and whether addressing needs is associated with a more positive outcome of the visit. One hundred twenty-eight affected and unaffected counselees from families with no known mutation, who were seen by one of fourteen counselors, participated. Pre- and post-visit questionnaires assessed correct knowledge about hereditary breast or colon cancer, perceived personal control (PPC), anxiety (STAI), risk perceptions, and (fulfillment of) needs (QUOTE-gene(ca)). Results demonstrated a pre- to post-visit significant increase in correct knowledge and PPC, and a significant decrease in STAI and risk perceptions. However, marked overestimation of risks persisted. Decrease in STAI and risk perceptions was significantly less pronounced in affected versus unaffected counselees. The majority of counselees were (very) satisfied about the extent to which their needs were addressed, albeit about one-fifth were not regarding emotional matters and explanations about their own cancer risk. Finally, the better counselees perceived their needs to be fulfilled, the significantly higher their PPC and the significantly lower their STAi scores were. Findings suggest that both unaffected and affected counselees should be counseled carefully. Also, a more effective service may be attained if counselors pay more attention to counselees' emotional needs and detail more inheritance and penetrance of mutated genes in relation to counselees' family history. (c) 2005 Wiley-Liss, Inc.
SN 1552-4825
PD AUG 15
PY 2005
VL 137A
IS 1
BP 27
EP 35
UT ISI:000231009900005
ER

PT J
AU Thorsen, L
Nystad, W
Stigum, H
Dahl, O
Klepp, O
Bremnes, RM
Wist, E
Fossa, SD
TI The association between self-reported physical activity and prevalence of depression and anxiety disorder in long-term survivors of testicular cancer and men in a general population sample
SO SUPPORTIVE CARE IN CANCER
AB Goals of work: Physical activity is claimed to have a beneficial influence on a person's mental health, though its impact may be different in cancer patients and individuals in the general population. The objective of this cross-sectional study was (1) to estimate the associations between the level of self-reported physical activity as a lifestyle factor (LPA) and the prevalence of depression and anxiety disorder in testicular cancer survivors (TCSs) and in men of similar age from the general population (GenPop), and (2) to examine whether these associations differ in the two groups. Patients and method: A total of 1260 TCSs and 20,207 men from the GenPop completed a questionnaire that assessed LPA, and depression and anxiety disorder on the Hospital Anxiety and Depression Scale (HADS). Main results: The prevalence of HADS-defined depression was lower among those who were physically active than in those who were physically inactive (TCSs 9% vs 17%, P < 0.001; GenPop 8% vs 15%, P < 0.001). Among physically inactive TCSs there was a trend towards higher a prevalence of HADS-defined anxiety disorder compared to physically active TCSs (P=0.07). In the GenPop this difference was statistically significant (P < 0.001). Multivariate analysis confirmed the association between LPA and HADS-defined depression in both the TCSs [adjusted odds ratio (aOR)=0.56; 95% confidence interval (CI) (0.31, 1.02)] and the GenPop [aOR=0.58; 95% CI (0.51, 0.65)], but not the association between LPA and HADS-defined anxiety disorder. The associations between LPA and HADS-defined depression and HADS-defined anxiety disorder did not differ between the TCSs and the GenPop. Conclusion: In both the TCSs and the GenPop, the prevalence of HADS-defined depression was higher among those who were physically inactive than among those who were physically active, with no intergroup difference. There was no association between LPA and prevalence of HADS-defined anxiety disorder in either of the groups after adjusting for background variables. Prospective studies are needed to allow causal inferences to be drawn.
SN 0941-4355
PD AUG
PY 2005
VL 13
IS 8
BP 637
EP 646
UT ISI:000230717900008
ER

PT J
AU Merrill, R
Brown, J
Byrd, A
Alder, S
Baker, R
White, G
Lyon, J
TI Risk of anxiety and depressive disorders in children and the parents of children undergoing cancer workup or treatment.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
SN 0002-9262
PD JUN 1
PY 2005
VL 161
IS 11
SU Suppl. S
BP S121
EP S121
UT ISI:000229594100480
ER

PT J
AU Grov, EK
Dahl, AA
Moum, T
Fossa, SD
TI Anxiety, depression, and quality of life in caregivers of patients with cancer in late palliative phase
SO ANNALS OF ONCOLOGY
AB Background: Limited research has been done on mental health and health-related quality of life (QOL) of primary caregivers (PCs) to patients staying at home with advanced cancer. This study examines anxiety, depression, and QOL in PCs of patients with cancer in the late palliative phase.
Patients and methods: The sample consisted of 49 PCs of women with breast cancer and 47 PCs of men with prostate cancer. QOL was rated with the Medical Outcome Study Short Form (SF-36), and mental health with the Hospital Anxiety and Depression Scale (HADS). The findings were compared with age-adjusted norm data (norm).
Results: Physical QOL was significantly higher than norm in both genders, while mental QOL was significantly lower in male PCs. The level of anxiety was significantly higher than norm in both genders. No significant difference for level of depression was found in either gender, while caseness of HADS-defined depression was significantly more prevalent in female PCs compared with norm.
Conclusion: PCs of both genders had significantly more anxiety than norm samples. Health care personnel in contact with PCs should consider screening them for mental symptoms and QOL and, if necessary, recommend further evaluation by their doctors.
SN 0923-7534
PD JUL
PY 2005
VL 16
IS 7
BP 1185
EP 1191
UT ISI:000230367500023
ER

PT J
AU Aarstad, HJ
Aarstad, AKH
Heimdal, JH
Olofsson, J
TI Mood, anxiety and sense of humor in head and neck cancer patients in relation to disease stage, prognosis and quality of life
SO ACTA OTO-LARYNGOLOGICA
AB Conclusion. At diagnosis, control patients had the lowest depression levels and anxiety scores, followed by those with limited HNSCC disease and these with extended HNSCC disease. Anxiety and depression levels at diagnosis predicted prognosis via an association with extent of disease. Sense of humor, but not anxiety or depression level, predicted lower QoL and depression levels at follow-up. Objective. To study the association between anxiety score, depression level at sense of humor at diagnosis in head and neck squamous cell carcinoma ( HNSCC) patients versus TNM stage, prognosis and depression level/quality of life (QOL) 6 years following diagnosis. A control group of patients with benign HN disease was also included. Material and methods. Male patients with newly diagnosed HNSCC ( n = 78) or benign HN ( n = 61) disease completed the following questionnaires: the Beck Depression Inventory, the Spielberger Trait Anxiety Inventory ( state) and the Svebak humor questionnaire. Patients with cachexia or those aged > 80 years were excluded. In the HNSCC patients, TNM stage, prognosis and QOL/depression level ( n = 27) were determined following successful therapy. Results. HNSCC patients reported high anxiety scores and lower depression levels than control patients, although there was overlap between the groups. N stage was associated with high anxiety scores and depression levels, whereas T stage was only associated with depression levels. Both anxiety scores and depression levels at diagnosis predicted prognosis through an association with TNM stage. Sense of humor, but not depression levels or anxiety scores, at diagnosis predicted QoL and depression levels at follow-up.
SN 0001-6489
PD MAY
PY 2005
VL 125
IS 5
BP 557
EP 565
UT ISI:000228799700020
ER

PT J
AU Rispoli, A
Pavone, I
Bongini, A
Di Loro, F
Ponchietti, R
Rizzo, M
TI Genitourinary cancer: Psychological assessment and gender differences - Anxiety and depression status among genitourinary cancer patients
SO UROLOGIA INTERNATIONALIS
AB Introduction: The study of the psychological impact in patients diagnosed with cancer is an important topic. Cancer diagnosis can induce feelings of anxiety, depression, fear of recurrence and produce treatment side effects. Men and women tend to differ in their way of dealing with emotional distress and physical illness. The aim of this study is to investigate and evaluate the prevalence and detection of psychological disease in patients with genitourinary tumors and outline the eventual gender differences. Materials and Methods: State-Trait Anxiety Inventory, Self-Rating Depression Scale and Illness Behavior Questionnaire were administered to 60 patients with genitourinary neoplasm. Results: Most patients show symptoms of depression and anxiety during the hospitalization. We have observed a significant gender differences in the psycho-emotional assessment. Conclusion: Our study confirms the importance to make available for the patients a proper and continuous support in pre- and postsurgery period to prevent the generation of psychological disorders. Copyright (C) 2005 S. Karger AG, Basel.
SN 0042-1138
PY 2005
VL 74
IS 3
BP 246
EP 249
UT ISI:000228254700011
ER

PT J
AU Grabowski, M
Hawkins, J
Mortimer, J
Ahmad, F
Naughton, M
TI Perceptions of anxiety and pain in cancer patients undergoing bone marrow biopsy.
SO ONCOLOGY NURSING FORUM
SN 0190-535X
PD MAR
PY 2004
VL 31
IS 2
BP 420
EP 420
UT ISI:000225438400161
ER

PT J
AU Dahl, AA
Haaland, CF
Mykletun, A
Bremnes, R
Dahl, C
Klepp, O
Wist, E
Fossa, SD
TI Study of anxiety disorder and depression in long-term survivors of testicular cancer
SO JOURNAL OF CLINICAL ONCOLOGY
AB Purpose To increase our knowledge of the prevalence of anxiety disorder and depression in long-term testicular cancer survivors (TCSs), and to identify variables associated with such caseness.
Patients and Methods Participants were 1,408 TCSs treated between 1980 and 1994 in Norway. Participants provided information about their medical, social, and familial situation on a questionnaire. They also completed the Hospital Anxiety and Depression Scale (HADS). Anxiety disorder and depression were defined by a score >= 8 on the HADS subscales. The prevalence rates were compared with age-adjusted norm data.
Results HADS-defined anxiety disorder was more prevalent in TCSs (19.2%; 95% Cl, 17.2% to 21.3%)than in the norm sample (13.5%; 95% Cl, 13.1% to 13.9%; P <.001), whereas the prevalence of HADS-defined depression did not differ from the norm (TCSs, 9.7%; 95% Cl, 8.1 % to 11.2% v norm, 10.1 %, 95% Cl, 9.5 to 10.5; P =.56). The relative risk for anxiety disorder was 1.49 (95% Cl, 1.31 to 1.69) and for depression the relative risk was 0.96 (95% Cl, 0.81 to1.14) in TCSs compared with norm. In multivariate analyses, HADS-defined anxiety disorder in TCSs was associated with young age, peripheral neuropathy, economic problems, alcohol problems, sexual problems, relapse anxiety, and having been treated for mental problems.
Conclusion Long-term TCSs have an increased risk of HADS-defined anxiety disorder that warrants clinical attention. Checking easily available demographic and TC-related data and use of a simple screening test such as HADS assists the identification of TCSs with anxiety disorder.
SN 0732-183X
PD APR 1
PY 2005
VL 23
IS 10
BP 2389
EP 2395
UT ISI:000228260200034
ER

PT J
AU Leon, C
Lacorte-Pi, T
Casas, F
Guix-Melcior, B
Alfaro, J
Broome, B
TI Anxiety, depression and quality of life in men with prostate cancer
SO RADIOTHERAPY AND ONCOLOGY
SN 0167-8140
PD OCT
PY 2004
VL 73
SU Suppl. 1
BP S387
EP S387
UT ISI:000226237701418
ER

PT J
AU Roth, AJ
Nelson, CJ
Rosenfeld, B
Warshowski, A
O'Shea, N
Scher, HI
Breitbart, W
Holland, JC
Curley-Smart, T
Reynolds, T
TI The revised Memorial Anxiety Scale for Prostate Cancer (MAX-PC-R): Validation of a scale to measure anxiety in men with prostate cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JAN
PY 2005
VL 14
IS 1
SU Suppl. S
BP S8
EP S8
UT ISI:000227182400013
ER

PT J
AU Haman, KL
Compas, BE
Murphy, BM
TI Social anxiety in head and neck cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JAN
PY 2005
VL 14
IS 1
SU Suppl. S
BP S47
EP S47
UT ISI:000227182400087
ER

PT J
AU Burgess, C
Cornelius, V
Love, S
Graham, J
Richards, M
Ramirez, A
TI Depression and anxiety in women with early breast cancer: five year observational cohort study
SO BRITISH MEDICAL JOURNAL
AB Objective To examine the prevalence of, and risk factors for, depression and anxiety in women with early breast cancer in the five years after diagnosis.
Design Observational cohort study.
Setting NHS breast clinic, London.
Participants 222 women with early breast cancer: 170 (77%) provided complete interview data up to either five years after diagnosis or recurrence.
Main outcome measures Prevalence of clinically important depression and anxiety (structured psychiatric interview with standardised diagnostic criteria) and clinical and patient risk factors, including stressful life experiences (Bedford College life events and difficulties schedule).
Results Nearly 50% of the women with early breast cancer had depression, anxiety, or both in the year after diagnosis, 25% in the second, third, and fourth years, and 15% in the fifth year. Point prevalence was 33% at diagnosis, falling to 15% after one year. 45% of those with recurrence experienced depression, anxiety, or both within three months of the diagnosis. Previous psychological treatment predicted depression, anxiety, or both in the period around diagnosis (one month before diagnosis to four months after diagnosis). Longer term depression and anxiety were associated with previous psychological treatment, lack of an intimate confiding relationship, younger age, and severely stressful non-cancer life experiences. Clinical factors were not associated with depression and anxiety at any time. Lack of intimate confiding support also predicted more protracted episodes of depression and anxiety.
Conclusion Increased levels of depression and anxiety in the first year after a diagnosis of early breast cancer highlight the need for dedicated service provision during this time. Psychological interventions for women with breast cancer who remain disease free should take account of the broader social context in which the cancer occurs, with a focus on improving social support.
SN 0959-535X
PD MAR 26
PY 2005
VL 330
IS 7493
BP 702
EP 705
UT ISI:000228071900016
ER

PT J
AU Cho, IH
Bang, YW
Bang, SM
Park, SH
TI Anxiety, depression and quality of life in patients with solid cancer during the palliative chemotherapy
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
SN 0924-977X
PD OCT
PY 2004
VL 14
SU Suppl. 3
BP S377
EP S378
UT ISI:000225460400556
ER

PT J
AU Roth, AJ
Nelson, C
Rosenfeld, B
Warshowsky, A
O'Shea, N
Reynolds, T
Slovin, S
Holland, JC
Scher, H
Curley-Smart, T
Breitbart, WS
TI The Revised Memorial Anxiety Scale for Prostate Cancer (MAX-PC-R): Validation of a scale to measure anxiety in men with prostate cancer
SO PSYCHOSOMATICS
SN 0033-3182
PD MAR-APR
PY 2005
VL 46
IS 2
BP 167
EP 167
UT ISI:000227459500036
ER

PT J
AU Wilson, K
Chochinov, HM
Graham, M
Allard, P
Chary, S
De Luca, M
Gagnon, P
TI Depression and anxiety disorders in palliative cancer care
SO JOURNAL OF PALLIATIVE CARE
SN 0825-8597
PD FAL
PY 2004
VL 20
IS 3
BP 260
EP 260
UT ISI:000224182900228
ER

PT J
AU Thamm, R
Geinitz, H
Zimmermann, F
Scholz, C
Winkler, C
Prause, N
Keller, M
Busch, R
Molls, M
TI Longitudinal evaluation of fatigue, anxiety and depression in patients with conformal radiation therapy (CRT) for prostate cancer
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
SN 0360-3016
PY 2004
VL 60
IS 1
SU Suppl. S
BP S569
EP S570
UT ISI:000223854700734
ER

PT J
AU Mantani, T
Saeki, T
Ozono, S
Yamawaki, S
Okamura, H
TI Factors related to anxiety in women with breast cancer and their husbands: Relationship between anxiety and alexithymia
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S61
EP S61
UT ISI:000223957800130
ER

PT J
AU Mehnert, A
TI Prevalence of post-traumatic stress disorder, anxiety and depression in a representative sample of breast cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S62
EP S62
UT ISI:000223957800131
ER

PT J
AU Sadeh-Tassa, D
Yagil, Y
Stadler, J
TI A comparison between first occurrence and recurrence of breast cancer: Anxiety, depression, PTSD
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S66
EP S67
UT ISI:000223957800141
ER

PT J
AU Waltz, P
Gex-Fabry, M
Murphy, MA
Hoesli, P
Chappuis, P
TI Psychosocial issues in predictive oncology: Evaluation of anxiety pre-, per- and post-genetic counseling and testing for familial breast and colorectal cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S83
EP S83
UT ISI:000223957800175
ER

PT J
AU Leon, C
Rovirosa, A
Casas, F
Farras, B
Gic, I
TI Evaluation of depression and anxiety among gynecologic cancer patients. A clinical controlled trial
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S144
EP S144
UT ISI:000223957800312
ER

PT J
AU Sherman, LK
Khalsa, D
TI Quetiapine for acute anxiety in cancer inpatients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S153
EP S154
UT ISI:000223957800334
ER

PT J
AU Bulotiene, G
Veseliunas, J
TI Women with breast cancer: The relationship of anxiety, depression, age, stage of cancer and cancer treatment to the quality of life
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S157
EP S157
UT ISI:000223957800341
ER

PT J
AU Wagner, LI
Rosenbloom, S
Purpura-Kilroy, L
Davis, K
Cella, D
TI Utilizing technology to deliver a patient and provider intervention for the management of cancer-related fatigue, pain, anxiety, and depression: Development of a web-based symptom management program
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S174
EP S174
UT ISI:000223957800379
ER

PT J
AU Grov, EK
Fossa, S
Moum, T
Dahl, AA
TI Anxiety, depression and quality of life in caregivers of patients with metastatic cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
SU Suppl. S
BP S190
EP S190
UT ISI:000223957800414
ER

PT J
AU Strasser, F
Degracia, B
Palmer, JL
Willey, J
Chang, HM
Bruera, E
TI Hypogonadism in patients with advanced cancer: Impact on fatigue, anxiety and depression, hemoglobin, and sexual desire
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUL 15
PY 2004
VL 22
IS 14
SU Suppl. S
BP 756S
EP 756S
UT ISI:000223512403001
ER

PT J
AU Caminiti, C
Campione, F
Sivelli, C
Diodati, F
Passalacqua, R
CA GICO Grp Study Information
TI Prevalence, predictors and risk factors of anxiety and depression in cancer patients. A nation-wide survey.
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUL 15
PY 2004
VL 22
IS 14
SU Suppl. S
BP 759S
EP 759S
UT ISI:000223512403010
ER

PT J
AU Pishniak, L
Ashkenazi, A
Sadeh-Tassa, D
Yagil, Y
Figer, A
TI Depression, anxiety and world assumptions amongst cancer patients
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUL 15
PY 2004
VL 22
IS 14
SU Suppl. S
BP 778S
EP 778S
UT ISI:000223512403086
ER

PT J
AU Jeffe, DB
Naughton, MJ
Weilbaecher, KN
Ali, MA
Aft, RL
TI Quality of life, depressed mood, and anxiety in women presenting with locally advanced breast cancer
SO JOURNAL OF CLINICAL ONCOLOGY
SN 0732-183X
PD JUL 15
PY 2004
VL 22
IS 14
SU Suppl. S
BP 791S
EP 791S
UT ISI:000223512403138
ER

PT J
AU Mystakidou, K
Tsilika, E
Parpa, E
Katsouda, E
Galanos, A
Vlahos, L
TI The hospital anxiety and depression scale in Greek cancer patients: psychometric analyses and applicability
SO SUPPORTIVE CARE IN CANCER
AB Goals of work: The aim of the present study was to validate the Greek version of the Hospital Anxiety and Depression Scale (HAD) in a palliative care unit. Patients and methods: The scale was translated with the "forward-backward" procedure to Greek. It was administered twice, with a 1-week interval, to 120 patients with advanced cancer. Together with the HAD scale, the patients also completed the Spielberger State-Anxiety Scale (STAI-S). Main results: Factor analyses identified a two-factor solution corresponding to the original two subscales of the HAD, which were found to be correlated. The Greek version of the HAD had Cronbach's alphas for the anxiety and depression scales of 0.887 and 0.703, respectively. Validity as performed using known-group analysis showed good results. Both anxiety and depression subscales discriminated well between subgroups of patients differing in disease severity as defined by ECOG performance status. Correlations between the HAD scale and the STAI-S was 0.681 for the anxiety subscale and 0.485 for the depression subscale. Conclusions: These psychometric properties of the Greek version of the HAD scale confirm it as a valid and reliable measure when administered to patients with advanced cancer.
SN 0941-4355
PD DEC
PY 2004
VL 12
IS 12
BP 821
EP 825
UT ISI:000225971100001
ER

PT J
AU Iwamitsu, Y
Shimoda, K
Abe, H
Tani, T
Okawa, M
Buck, R
TI Anxiety, emotional suppression, before and after breast and psychological distress cancer diagnosis
SO PSYCHOSOMATICS
AB The authors examined the influence of anxiety and emotional suppression on psychological distress in 21 patients with breast cancer and 72 patients with benign breast tumor. The patients with breast cancer who suppressed emotion and had chronically high levels of anxiety felt higher levels of emotional distress both before and after the diagnosis. Such patients need psychological interventions, including encouragement to express and communicate their emotions, immediately after disclosure of the diagnosis to help maintain psychological adjustment in the face of the disease.
SN 0033-3182
PD JAN-FEB
PY 2005
VL 46
IS 1
BP 19
EP 24
UT ISI:000226153100004
ER

PT J
AU Tsunoda, A
Nakao, K
Kamiyama, KG
Hiratsuka, K
Yamazaki, K
Yasuda, N
Tsunoda, Y
Kusanoa, M
TI Anxiety and depression and quality of life in colorectal cancer patients
SO DISEASES OF THE COLON & RECTUM
SN 0012-3706
PD JUN
PY 2004
VL 47
IS 6
BP 1098
EP 1099
UT ISI:000221776900315
ER

PT J
AU Leon, C
Rovirosa, A
Casas, F
Farrus, B
Gic, I
Biete, A
Craven-Bartle, J
Sierra, J
Arcusa, A
TI Anxiety and depression in gynaecologic cancer patients before, during and after brachytherapy. a randomized study
SO RADIOTHERAPY AND ONCOLOGY
SN 0167-8140
PD MAY
PY 2004
VL 71
SU Suppl. 2
BP S74
EP S74
UT ISI:000222468200156
ER

PT J
AU Macleod, U
Ross, S
Fallowfield, L
Watt, GCM
TI Anxiety and support in breast cancer: is this different for affluent and deprived women? A questionnaire study
SO BRITISH JOURNAL OF CANCER
AB A postal questionnaire was sent to affluent and deprived women with breast cancer in order to compare psychosocial aspects of care with the purpose of understanding the balance of care and explaining why deprived women have poorer outcomes. Data were collected regarding reported sources of information, SF-36 scores and ongoing causes of anxiety. The results demonstrate that affluent women were more likely to have received information from their hospital specialist (94.8 vs 76.0%) and from a breast care nurse (70.1 vs 40.0%) than deprived women. They were also more likely to have received information from magazines (50.6 vs 33.0%), newspapers (45.5 vs 22.0%) and television news ( 45.5 vs 26.0%). Deprived women had poorer SF-36 scores than affluent women, and reported greater anxiety about money (12.2 vs 2.8%), other health problems (22.1 vs 8.2%) and family problems (17.5 vs 6.9%). Personal and professional support is clearly important for patients with breast cancer. Health professionals need to be aware of the greater psychological distress demonstrated by deprived women, even some years after diagnosis with breast cancer, and seek to address it.
SN 0007-0920
PD AUG 31
PY 2004
VL 91
IS 5
BP 879
EP 883
UT ISI:000223510500012
ER

PT J
AU Edwards, B
Clarke, V
TI The psychological impact of a cancer diagnosis on families: The influence of family functioning and patients' illness characteristics on depression and anxiety
SO PSYCHO-ONCOLOGY
AB A diagnosis of cancer is a very stressful event for the patients and their families. Patients, partners and other family members can suffer from clinical levels of depression and severe levels of anxiety and stress reactions. The similarity in levels of distress between patients and partners and patients and offspring suggests that there are common factors that impact on families' distress levels. The current study examined levels of depression and anxiety in newly diagnosed adult patients (n = 48) and their adult relatives (n = 99). Family functioning and patients' illness characteristics were identified as factors that might impact on families' depression and anxiety. Results from multilevel models indicated that family functioning was important. Families that were able to act openly, express feelings directly, and solve problems effectively had lower levels of depression. Direct communication of information within the family was associated with lower levels of anxiety. Aside from differences anxiety due to cancer type, patients' illness characteristics appear to be risk factors in patients' but not relatives' depression and anxiety. The results from the current study suggest that researchers and clinicians need to be family-focused as cancer affects the whole family, not just the patient. Copyright (C) 2003 John Wiley Sons, Ltd.
SN 1057-9249
PD AUG
PY 2004
VL 13
IS 8
BP 562
EP 576
UT ISI:000223278900006
ER

PT J
AU Valdimarsdottir, U
Helgason, AR
Furst, CJ
Adolfsson, J
Steineck, G
TI Awareness of husband's impending death from cancer and long-term anxiety in widowhood: a nationwide follow-up
SO PALLIATIVE MEDICINE
AB Background: We investigated the predictors and long-term consequences of awareness time - the length of time a woman is aware of her husband's impending death from cancer. Methods: All women (n = 506) living in Sweden under 80 years of age who lost their husband/partner owing to cancer of the prostate in 1996 or of the urinary bladder in 1995 or 1996 were followed with an anonymous postal questionnaire, 2-4 years after their loss. Results: We received completed questionnaires from 379 of the widows. Of these, 55 (15%) reported an awareness time of 24 hours or less, 56 (15%) of 3-6 months and 95 (26%) of one year or more. The associations between the awareness time and morbidity were of a reverted 'J-shape,' with awareness time of 24 hours or less carrying the highest risk and 3-6/6-12 months the lowest. On comparing the awareness time of 24 hours or less with 3-6 months (preformed response category), the relative risks for anxiety were found to be 1.9 (1.0-3.6) (visual digital scale) and 4.5 (1.0-20.0) for intake of tranquillising drugs. Those not informed of their husband's fatal condition or not provided with psychological support by caregivers during their husband's last months of life had an increased risk of a short awareness time. Conclusions: During a man's terminal cancer illness, the wife's awareness time varies considerably and is influenced by information and psychological support from caregivers. A short awareness time may result in an additional and avoidable psychological trauma.
SN 0269-2163
PY 2004
VL 18
IS 5
BP 432
EP 443
UT ISI:000222788200005
ER

PT J
AU Love, AW
Grabsch, B
Clarke, DM
Bloch, S
Kissane, DW
TI Screening for depression in women with metastatic breast cancer: a comparison of the Beck Depression Inventory Short Form and the Hospital Anxiety and Depression Scale
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
AB Objective: To compare two self-report questionnaires for identifying possible depression in women with metastatic breast cancer.
Method: We conducted structured psychiatric interviews and administered the Beck Depression Inventory Short Form (BDI-SF) and Hospital Anxiety and Depression Scale (HADS) to 227 women with stage IV breast cancer. The accuracy for identifying DSM-IV-defined major and minor depression was examined. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were calculated and receiver operating characteristic curves plotted.
Results: Seventy-four (32.6%) patients satisfied DSM-IV criteria for a depressive disorder. With a cut-off of 4, the BDI-SF had a sensitivity of 0.84, specificity of 0.63, and PPV of 0.52. A cut-off of 11 on the HADS-Depression scale (HADS-D) resulted in sensitivity, specificity, and PPV of 0.16, 0.97, and 0.75, respectively. For major depression alone, the BDI-SF with a cut-off of 5 had excellent sensitivity but poor PPV; the HADS, with a cut-off of 7, had weak sensitivity and PPV.
Conclusions: Overall, the two scales perform similarly in identifying major depression, while the BDI-SF is the more useful in screening for DSM-IV major or minor depression categories in this clinical group.
SN 0004-8674
PD JUL
PY 2004
VL 38
IS 7
BP 526
EP 531
UT ISI:000222705700007
ER

PT J
AU Consedine, NS
Magai, C
Krivoshekova, YS
Ryzewicz, L
Neugut, AI
TI Fear, anxiety, worry, and breast cancer screening behavior: A critical review
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
AB Anxiety, fear, and worry are variously described as facilitators and barriers of breast cancer screening. However, several contradictions are evident in this research. A review article described the literature regarding the relations among fear, anxiety, and worry, along with emotion regulatory styles, and breast cancer screening behaviors before critiquing it in an attempt to uncover preliminary explanations for these discrepancies. Three main conclusions are drawn. First, it is suggested that researchers need to clearly define the components of cancer and the screening process that women are afraid of as each may bear a different relation to screening behavior. Second, greater care needs to be taken to employ psychometrically valid and reliable measures of fear and anxiety. Third, studies need to more systematically test findings across the minority and ethnic groups at greatest risk. A framework is presented and suggestions regarding the continued development of this promising area of research are made.
SN 1055-9965
PD APR
PY 2004
VL 13
IS 4
BP 501
EP 510
UT ISI:000220724400002
ER

PT J
AU Humphris, GM
Rogers, SN
TI Recurrence fears, anxiety and depression in oral facial cancer patients.
SO JOURNAL OF DENTAL RESEARCH
SN 0022-0345
PD DEC
PY 2003
VL 82
SI Sp. Iss. C
BP 496
EP 496
UT ISI:000189078303000
ER

PT J
AU Osborne, RH
Elsworth, GR
Sprangers, MAG
Oort, FJ
Hopper, JL
TI The value of the Hospital Anxiety and Depression Scale (HADS) for comparing women with early onset breast cancer with population-based reference women
SO QUALITY OF LIFE RESEARCH
AB Background: The Hospital Anxiety and Depression Scale (HADS) is frequently used in cancer studies, yet its utility for comparing people with cancer with people in the community is uncertain. Methods: HADS scores were obtained from population-based samples of women with (n = 731) and without (n = 158) early-onset breast cancer. Psychometric properties were examined using differential item functioning (DIF) which is the presence of systematic group differences in certain response items independent of the trait being measured. Results: Women with breast cancer scored lower than reference women on anxiety (mean (SD) 7.5 (4.3) vs. 8.2 (4.0); p = 0.06) and depression (3.3 (3.2) vs. 4.2 (3.0); p = 0.003). Group differences remained following adjustment for demographics. Time since diagnosis was not related to anxiety or depression scores. DIF was present in two anxiety and five depression items. Adjustment for DIF did not substantially change the anxiety or depression group differences. Conclusion: Specific sampling or DIF effects do not explain the observation that women with breast cancer have lower levels of anxiety and depression than population controls. The psychometric properties of the HADS appear to be acceptable in these groups.
SN 0962-9343
PD FEB
PY 2004
VL 13
IS 1
BP 191
EP 206
UT ISI:000188855800021
ER

PT J
AU Baum, C
Gessert, A
TI Mindfulness-based stress reduction (MBSR) classes as a tool to decrease the anxiety of cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JAN
PY 2004
VL 13
IS 1
SU Suppl. S
BP S13
EP S13
UT ISI:000188425000023
ER

PT J
AU Humphris, GM
Rogers, S
McNally, D
Lee-Jones, C
Brown, J
Vaughan, D
TI Fear of recurrence and possible cases of anxiety and depression in orofacial cancer patients
SO INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
AB Recurrence risk in orofacial cancer patients is relatively high in comparison to other cancers. Little information exists on whether patients are unduly concerned over the possibility of recurrence and the association of this concern with psychological morbidity. Aim of study was to assess fear of recurrence and psychological morbidity in orofacial cancer patients. Two samples of patients with orofacial cancer were followed prospectively. First sample (n = 87) were consecutively drawn 3 months and 7 months following initial treatment. Second sample (n = 100) were cross-sectionally drawn from out-patient list and followed 2 years later. A single question item was employed to assess fear of recurrence used in previous work. Hospital Anxiety and Depression Scale was adopted as the measure of psychological morbidity. A prospective survey design was employed. Over 80% of patients expressed concern over the possibility of recurrence at 3 months post treatment. This level reduced to 72% at 7 months (P = 0.06). Approximately two-thirds of patients sampled cross-sectionally were concerned at both assessment occasions. Psychological morbidity was greatest at 3 months post treatment (possible cases: anxiety 37% and depression 28%). Women were more likely to report anxiety at possible case level) than men 3 months following treatment (P<0.05). Patients aged 65 or more years were less concerned about recurrence. This effect was significant on both occasions that sample two patients were assessed (P's<0.002). Very few patients who expressed no concern about recurrence, at 3 months, were found to report anxiety or depression sufficient to be recognized as a possible case (3 and 0% respectively). The positive association between psychological morbidity and fears of recurrence was significant at the majority of data collection points, with the exception that depression was more independent of these concerns.
SN 0901-5027
PD OCT
PY 2003
VL 32
IS 5
BP 486
EP 491
UT ISI:000186720500006
ER

PT J
AU Deimling, GT
Bowman, K
Kabana, B
TI Depression, anxiety and burden of disability among older adult long-term cancer survivors: racial and gender differences
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S121
EP S122
UT ISI:000183225400144
ER

PT J
AU Roth, AJ
TI Screening for distress and anxiety in prostate cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S123
EP S124
UT ISI:000183225400150
ER

PT J
AU Halim, MS
Cahya, IN
TI Spiritual experience and death anxiety in Indonesian cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S150
EP S150
UT ISI:000183225400227
ER

PT J
AU Karasawa, K
Horikawa, N
Seki, K
Kohno, M
Shinoda, H
Nasu, S
Muramatsu, H
Maebayashi, K
Mitsuhashi, N
TI The progress of anxiety and depression in cancer patients who receiving radiotherapy
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S173
EP S173
UT ISI:000183225400294
ER

PT J
AU Moura, MJ
TI Depression and anxiety in parents of children with cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S200
EP S200
UT ISI:000183225400370
ER

PT J
AU Schweiger, C
Vollmer, TC
Wittmann, M
Hiddemann, W
TI Anxiety and depression as predictors for the maladaptive preoccupation with death and dying in cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S201
EP S201
UT ISI:000183225400374
ER

PT J
AU Moura, MJ
Fiuza, I
Bacalhau, MR
TI Anxiety and depression evaluation in mothers of children with cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S210
EP S211
UT ISI:000183225400401
ER

PT J
AU Roth, A
Rosenfeld, B
Warshowsky, A
O'Shea, N
Reynolds, T
Scher, HI
Breitbart, W
TI The revised Memorial Anxiety Scale for Prostate Cancer (MAX-PC): further validation of a scale to measure anxiety in men with prostate cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S220
EP S220
UT ISI:000183225400427
ER

PT J
AU Ingram, D
Browne, G
Reyno, L
Gafni, A
Roberts, J
TI Prevalence, correlates and cost of anxiety and affective disorder in men with prostate cancer one year after initial assessment
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S229
EP S229
UT ISI:000183225400451
ER

PT J
AU Hughes, R
Angen, M
TI Causes of anxiety in women with hereditary breast and ovarian cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S243
EP S243
UT ISI:000183225400494
ER

PT J
AU Gil, F
Travado, L
Tomamichel, M
Grassi, L
TI Visual Analogue Scales (VAS) and Hospital Anxiety Depression (HAD) scale as tools for evaluating distress in cancer patients: a multi-center Southern European study
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUN
PY 2003
VL 12
IS 4
SU Suppl. S
BP S257
EP S257
UT ISI:000183225400537
ER

PT J
AU Smith, EM
Gomm, SA
Dickens, CM
TI Assessing the independent contribution to quality of life from anxiety and depression in patients with advanced cancer
SO PALLIATIVE MEDICINE
AB Background: The aim of palliative care services is to ensure the best quality of life for patients and their carers. Depression is common amongst palliative care patients and has been shown to adversely affect quality of life. This study aimed to examine the independent contribution of depression to quality of life. Objective: To investigate the hypothesis that a) illness severity, pain, anxiety and depression are all associated with impaired health-related quality of life and b) once the effects of illness severity have been adjusted for, there is further independent contribution to quality of life from anxiety and depression. Method: Consecutive patients with advanced cancer under the care of palliative care services were screened. Sixty-eight patients were evaluated for levels of anxiety and depression, severity of illness, pain severity and health-related quality of life. Results: Thirty-three males and 35 females were recruited and had an age range of 41-93 years (median 71). Seventeen (25%) of patients were anxious [anxiety score greater than or equal to 11 on the Hospital Anxiety and Depression Scale (HADS)], 15 (22%) were depressed (HADS depression score greater than or equal to 11). After controlling for the effects of pain and illness severity, anxiety and depression were independently associated with global health status, emotional and cognitive functioning, and fatigue. Anxiety further contributed significantly towards social functioning, nausea and vomiting. Conclusions: This study has confirmed that pain, anxiety and depression were associated with impaired quality of life. Anxiety and depression contributed independently towards various dimensions of quality of life. Longitudinal studies are required to examine the direction of the causal association between pain and depression in patients receiving palliative care.
SN 0269-2163
PY 2003
VL 17
IS 6
BP 509
EP 513
UT ISI:000185319800007
ER

PT J
AU Geinitz, H
Zimmermann, FB
Thamm, R
Keller, M
Busch, R
Molls, M
TI Fatigue 2.5 years after adjuvant radiotherapy (RT) in patients with breast cancer: Values before and immediately after treatment and their correlation to anxiety, depression and functional limitations
SO STRAHLENTHERAPIE UND ONKOLOGIE
SN 0179-7158
PD JUN
PY 2002
VL 178
SU Suppl. 1
BP 74
EP 74
UT ISI:000176659600292
ER

PT J
AU Burgess, C
Ramirez, A
Cornelius, V
Love, S
Graham, J
Richards, M
TI Prevalence and risk factors for depression and anxiety in women during the five years after a diagnosis of breast cancer
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD SEP
PY 2003
VL 12
IS 6
BP 642
EP 642
UT ISI:000184973900036
ER

PT J
AU Mattar, PN
Killeen, K
Freier, MC
Swensen, R
Pivonka, J
Babikian, T
Salo, J
Hardesty, RA
TI Breast cancer: Does awareness of risk factors increase or decrease anxiety?
SO JOURNAL OF INVESTIGATIVE MEDICINE
SN 1081-5589
PD FEB
PY 2003
VL 51
SU Suppl. 1
BP S131
EP S131
UT ISI:000180569600235
ER

PT J
AU Hensley, ML
Robson, ME
Kauff, ND
Korytowsky, B
Castiel, M
Ostroff, J
Hurley, K
Hann, LE
Colon, J
Spriggs, D
TI Pre- and postmenopausal high-risk women undergoing screening for ovarian cancer: anxiety, risk perceptions, and quality of life
SO GYNECOLOGIC ONCOLOGY
AB Objective. Recommendations for women at high risk of ovarian cancer include prophylactic salpingo-oophorectomy (PSO) or screening with transvaginal ultrasonography (TVUS) and CA125 levels. The best strategy for improving survival and maintaining quality of life in high-risk women is not known. Premenopausal women may be more reluctant than postmenopausal women to undergo PSO. However, the risk of false-positive screening results may be more likely in premenopausal women, posing potential psychological risk for those enrolled in high-risk ovarian cancer surveillance programs. We sought to determine whether anxiety, depression, perception of ovarian cancer risk, and false-positive test frequency differed between high-risk premenopausal and postmenopausal women initiating ovarian cancer screening.
Methods. High-risk women aged greater than or equal to 30 years enrolling in a TVUS plus CA125 ovarian cancer screening study completed standard QOL (SF-36), cancer-specific anxiety (IES), depression (CES-D), and ovarian cancer risk perception measures. CA125 > 35 and TVUS showing solid or complex cystic ovarian masses were considered abnormal. Abnormal tests were repeated after 4-6 weeks. Persistently abnormal tests prompted a search for malignancy. Tests that normalized on repeat were considered false positive.
Results. One hundred forty-seven high-risk women, median age 46 (range, 30-78), 78 premenopausal and 69 postmenopausal, had greater than or equal to 1 TVUS/CA125/outcome assessment. Premenopausal women were more likely than postmenopausal women to consider themselves at higher risk of ovarian cancer compared with women their age (P < 0.001) and compared with women with similar family histories (P < 0.001). Mean personal perception of lifetime risk of ovarian cancer among premenopausal women was 37% (range, 0-90%) versus 26% (range, 0-60%) among postmenopausal women (P = 0.02). While general QOL and depression scores were similar, 38% of premenopausal women reported high anxiety versus 27% of postmenopausal women (P = 0.03). Thirty percent of women required repeat CA125 or TVUS after first screening; 10.8% of premenopausal women versus 4.6% of postmenopausal women required repeat CA125; and 23.3% of premenopausal and 20.6% of postmenopausal women required repeat TVUS. One postmenopausal woman with persistently rising CA125 > 100 had negative mammography, colonoscopy, and dilation and curettage/bilateral salpingo-oophorectomy. All other abnormal tests normalized on repeat. Two premenopausal women withdrew due to anxiety following false-positive CA125 results. Five women (2 premenopausal, 3 postmenopausal) with normal TVUS/CA125 screening tests elected PSO, with benign findings.
Conclusion. Premenopausal women perceive their ovarian cancer risk to be higher, report greater ovarian cancer risk-related anxiety, and are more likely to have false-positive screening results than postmenopausal women. Few high-risk women elect PSO in the short term. Knowledge of the frequency of false-positive screening results and psychosocial outcomes is important for high-risk women choosing strategies for managing ovarian cancer risk. (C) 2003 Elsevier Science (USA). All rights reserved.
SN 0090-8258
PD JUN
PY 2003
VL 89
IS 3
BP 440
EP 446
UT ISI:000183682300017
ER

PT J
AU Hartl, K
Janni, W
Kastner, R
Sommer, H
Stauber, M
TI Long-term quality of life, body image and anxiety in women after breast cancer
SO GEBURTSHILFE UND FRAUENHEILKUNDE
AB Purpose: Research on long-term quality of life after breast cancer has produced conflicting results. We investigated the impact of age, recurrence, and type of primary surgery on different aspects of long-term quality of life in women treated for breast cancer.
Methods: A total of 306 women completed the QLQ-C30 (Version 2.0) questionnaire an average of 4.2 years after primary treatment for stage I-Ill breast cancer. Supplementary scales included body image, satisfaction with surgical treatment, and fear of recurrence.
Results: The women had minor impairment of quality of life (67.0) and body image (25.9), a high degree of satisfaction with surgical treatment (6.8), and considerable fear of recurrence (61.4). There was no correlation between age and quality of life. Women with recurrence did not differ from those without recurrence in the symptom scales of the questionnaire. Women with recurrence reported lower quality of life (P < 0.01), less satisfaction with surgical treatment (P < 0.04), and more anxiety (P = 0.02). The QLQ-C30 questionnaire failed to demonstrate a difference in overall long-term quality of life between women who had undergone breast-conserving therapy and those who underwent mastectomy. In contrast, primary surgical treatment did have an impact on the additional psychological scales: women after mastectomy had a less favorable body image (P < 0.01), less satisfaction with surgical treatment (P < 0.01) but also less fear of recurrence (P < 0.01) than women after conservative surgery.
Conclusion: These data support the hypothesis that the standardized QLQ-C30 questionnaire does not sufficiently cover all relevant aspects of quality of life and that it might be complemented with aspects specific for breast cancer, such as body image, satisfaction with surgical treatment, and anxiety.
SN 0016-5751
PD MAY
PY 2003
VL 63
IS 5
BP 446
EP 452
UT ISI:000183346900006
ER

PT J
AU Roth, AJ
Rosenfeld, B
Kornblith, AB
Gibson, C
Scher, HI
Curley-Smart, T
Holland, JC
Breitbart, W
TI The memorial anxiety scale for prostate cancer - Validation of a new scale to measure anxiety in men with prostate cancer
SO CANCER
AB BACKGROUND. The psychological difficulties facing men with prostate cancer are 2 acknowledged widely, yet identifying men who may benefit from mental health treatment has proven to be a challenging task. The authors developed the Memorial Anxiety Scale for Prostate Cancer (MAX-PC) to facilitate the identification and assessment of men with prostate cancer-related anxiety. This scale consists of three subscales that measure general prostate cancer anxiety, anxiety related to prostate specific antigen (PSA) levels in particular, and fear of recurrence.
METHODS. Ambulatory men with prostate cancer (n = 385 patients) were recruited from clinics throughout the United States. Prior to routine PSA tests, participants completed a baseline assessment packet that included the Hospital Anxiety and Depression Scale; the Distress Thermometer; the Functional Assessment of Cancer Therapy Scale, Prostate Module; and measures of role functioning, sleep, and urinary functioning. PSA values from the last three tests also were collected. Follow-up evaluation was completed within 2 weeks after patients learned of their PSA test result using a subset of these scales.
RESULTS. Analysis of the MAX-PC revealed a high degree of internal consistency and test-retest reliability for the total score and for the three subscales, although reliability was somewhat weaker for the PSA Anxiety Scale. Concurrent validity was demonstrated by correlations between the MAX-PC and measures of anxiety. 5 Overall changes in PSA levels were correlated only modestly with changes in MAX-PC scores (correlation coefficient, 0.13; P = 0.02).
CONCLUSIONS. The MAX-PC appears to be a valid and reliable measure of anxiety in men with prostate cancer receiving ambulatory care. (C) 2003 American Cancer Society.
SN 0008-543X
PD JUN 1
PY 2003
VL 97
IS 11
BP 2910
EP 2918
UT ISI:000183022100027
ER

PT J
AU Sundar, S
Symonds, P
TI Cancer patients' anxiety
SO LANCET
SN 0140-6736
PD MAY 17
PY 2003
VL 361
IS 9370
BP 1746
EP 1747
UT ISI:000182919700043
ER

PT J
AU Osborne, RH
Elsworth, GR
Hopper, JL
TI Age-specific norms and determinants of anxiety and depression in 731 women with breast cancer recruited through a population-based cancer registry
SO EUROPEAN JOURNAL OF CANCER
AB The aim of this study was to determine population norms and determinants of anxiety and depression in a population-based sample of 731 women with breast cancer (aged 23-60 years) with the Hospital Anxiety and Depression scale (HADS). The prevalence of 'probable' psychological morbidity due to anxiety was 23% and due to depression was 3%. When the women identified as 'possible' cases were included, the respective proportions were 45 and 12%. Higher anxiety was present in younger, less educated women not born in Australia. There was no clear pattern of risk factors for depression. These population-based findings highlight the need for clinicians to be aware that age, education and country of birth may identify a particularly vulnerable subgroup. While brief scales such as the HADS are limited in their ability to accurately predict a clinical diagnosis, high scores identify those who may warrant referral for clinical evaluation. (C) 2003 Elsevier Science Ltd. All rights reserved.
SN 0959-8049
PD APR
PY 2003
VL 39
IS 6
BP 755
EP 762
UT ISI:000182554900017
ER

PT J
AU Cheung, YL
Molassiotis, A
Chang, AM
TI The effect of progressive muscle relaxation training on anxiety and quality of life after stoma surgery in colorectal cancer patients
SO PSYCHO-ONCOLOGY
AB The aim of the study was to evaluate the effects of the use of progressive muscle relaxation training (PMRT) on anxiety and quality of life in colorectal cancer patients after stoma surgery. A randomised controlled trial was used with repeated measures assessment over 10 weeks post-stoma surgery. Fifty-nine patients participated in the study and were randomised to a control group receiving routine care (n = 30) and an experimental group receiving routine care and PMRT through two teaching sessions and practice at home for the first 10 weeks. The State-Trait Anxiety Inventory and two Quality of Life Scales were used to collect the data of interest in three occasions, namely during hospitalisation, at week 5 and at week 10 post-surgery. The use of PMRT significantly decreased state anxiety and improved generic quality of life in the experimental group (P < 0.05), especially in the domains of physical health, psychological health, social concerns and environment. Social relationships decreased in both groups. In relation to the disease-specific quality of life measure, differences were observed only in the 10-week assessment, with the experimental group reporting better quality of life at 10 weeks, but not over time as compared to the control group. The use of PMRT should be incorporated in the long-term care of colorectal cancer patients, as it can improve their psychological health and quality of life. This may be a cost-effective intervention that needs minimal training and could easily be offered to those patients that they would like to use it as part of the specialist care provided to stoma patients. Copyright (C) 2002 John Wiley Sons, Ltd.
SN 1057-9249
PD APR-MAY
PY 2003
VL 12
IS 3
BP 254
EP 266
UT ISI:000182199600004
ER

PT J
AU Fossa, SD
Dahl, AA
Loge, JH
TI Fatigue, anxiety, and depression in long-term survivors of testicular cancer
SO JOURNAL OF CLINICAL ONCOLOGY
AB Purpose: To investigate the prevalence of chronic fatigue (CF), the levels of anxiety and depression, and the correlation between these conditions in long-term survivors of testicular cancer (TCSs). Occurrence of CF in TCSs is compared with findings in male survivors of Hodgkin's disease (HDSs) and in males from the general population (GenPop).
Methods: TCSs, HDSs, and two cohorts of the GenPop completed the Fatigue Questionnaire (FQ) and the Hospital Anxiety and Depression Scale (HADS) as part of a questionnaire survey. Cases of CF were identified according to published cut-offs, and the levels of anxiety (HADS-A) and depression (HADS-D) were calculated.
Results: Among 791 TCSs,16% displayed CF (HDSs, 24%; GenPop, 10%). In the age group younger than 30 years, the prevalence of CF was higher in TCSs than in the GenPop (P < .01). In TCSs, age, anxiety, depression, and comorbidity were independent predictors of CF. The mean HADS-A score in TCSs was significantly above the comparable figure of the GenPop and similar to that of HDSs. The mean HADS-D score in TCSs was below that of the GenPop. The highest and lowest mean scores of HADS-A and HADS-D were observed in the youngest TCSs.
Conclusion: The prevalence of CF is less in TCSs than in HDSs but exceeds that of the GenPop. Together with comorbidity and age, anxiety and depression predict CF in TCSs, warranting psychiatric intervention for cases of CF among TCSs. Anxiety is a larger problem in TCSs than depression,. particularly among the youngest TCSs. (C) 2003 by American Society of Clinical Oncology.
SN 0732-183X
PD APR 1
PY 2003
VL 21
IS 7
BP 1249
EP 1254
UT ISI:000181973400008
ER

PT J
AU Sloman, R
TI Relaxation and imagery for anxiety and depression control in community patients with advanced cancer
SO CANCER NURSING
AB A community-based nursing study was conducted in Sydney, Australia, to compare the effects of progressive muscle relaxation and guided imagery on anxiety, depression, and quality of life in people with advanced cancer. In this study, 56 people with advanced cancer who were experiencing anxiety and depression were randomly assigned to 1 of 4 treatment conditions: (1) progressive muscle relaxation training, (2) guided imagery training, (3) both of these treatments, and (4) control group. Subjects were tested before and after learning muscle relaxation and guided imagery techniques for anxiety, depression, and quality of life using the Hospital Anxiety and Depression scale and the Functional Living Index-Cancer scale. There was no significant improvement for anxiety; however, significant positive changes occurred for depression and quality of life.
SN 0162-220X
PD DEC
PY 2002
VL 25
IS 6
BP 432
EP 435
UT ISI:000180833900003
ER

PT J
AU Lofters, A
Juffs, HG
Pond, GR
Tannock, IF
TI "PSA-ITIS": Knowledge of serum prostate specific antigen and other causes of anxiety in men with metastatic prostate cancer
SO JOURNAL OF UROLOGY
AB Purpose: High or increasing prostatic specific antigen (PSA) levels may be a source of anxiety in patients with metastatic prostate cancer.
Materials and Methods: Patients with metastatic prostate cancer completed questionnaires, including the Prostate Cancer Specific Quality of Life Instrument, Hospital Anxiety and Depression Scale, and a questionnaire to assess the impact of the knowledge of PSA levels on anxiety. These were completed at home more than 3 days before or after a clinic appointment and returned by mail. Patient medical history was obtained from the record.
Results: Of the 65 patients who consented to the study 52 returned the completed questionnaires. Median age was 70 years (range 55 to 86) and median time since diagnosis was 53 months. Of the patients 81% had hormone resistant disease. Most reported good overall quality of life with a median Prostate Cancer Specific Quality of Life Instrument score of 93 (maximum 100). Of the patients 77% indicated that PSA levels were one of the ways and 44% indicated they were the only way that they knew whether disease was progressing. When asked to rate references for treatment outcome, 25% of the men rated decreasing PSA and worse physical symptoms above increasing PSA and better physical symptoms. If measurement of PSA levels ceased, 52% of patients would believe that their doctor was giving up on them and only 1 would be relieved. Before receiving PSA results 76% reported some level of anxiety and 15% reported extreme anxiety.
Conclusions: PSA related anxiety represents a substantial problem in patients with metastatic prostate cancer.
SN 0022-5347
PD DEC
PY 2002
VL 168
IS 6
BP 2516
EP 2520
UT ISI:000179399900043
ER

PT J
AU Petersen, RW
Quinlivan, JA
TI Preventing anxiety and depression in gynaecological cancer: a randomised controlled trial
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
AB Objective To examine the effect of counselling and relaxation intervention on psychological symptoms in patients with gynaecological cancer between the post-operative period and the six-week review.
Design Randomised controlled trial.
Participants Fifty-three patients with gynaecological cancer.
Setting Three Australian tertiary referral hospitals.
Methods Fifty-three patients were randomised to control or intervention and completed the baseline Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire-28 (GHQ-28) questionnaires. The intervention consisted of a relaxation and counselling session performed by a senior doctor. Follow up questionnaires were completed at six weeks. Demographic and tumour data were collated independently.
Results Complete data were available on 50 patients. There were no significant differences in demographic, social support or tumour characteristics between the two groups. Multivariate analysis determined that only the intervention and baseline score were significant predictors of outcome. The intervention was associated with a significant reduction in total HADS score (P = 0.002). The reduction was seen in both anxiety and moderate depression subscales (P = 0.001 and P = 0.02). The intervention was also associated with a significant reduction in total GHQ-28 score and in three of the four subscale scores (somatisation, anxiety and personality development; all P < 0.02). However, no significant difference was found in the fourth subscale of major depression.
Conclusion A relaxation and counselling intervention performed by a treating doctor reduces psychological , symptoms in women with a new diagnosis of gynaecological cancer.
SN 1470-0328
PD APR
PY 2002
VL 109
IS 4
BP 386
EP 394
UT ISI:000179220000007
ER

PT J
AU Stark, D
Kiely, M
Smith, A
Velikova, G
House, A
Selby, P
TI Anxiety disorders in cancer patients: Their nature, associations, and relation to quality of life
SO JOURNAL OF CLINICAL ONCOLOGY
AB Purpose: We aimed to estimate the prevalence and types of anxiety disorders diagnosed according to standardized criteria in cancer patients, to compare screening tools in detecting them, and to examine their demographic, oncologic, and psychosocial associations.
Methods: In this cross-sectional observational study of 178 subjects with lymphoma, renal cell carcinoma, malignant melanoma, or plasma cell dyscrasia, we related responses to questionnaires (administered by computer touch-screen) measuring psychological symptoms, quality of life (QOL), and social support to standardized psychiatric interviews and cancer management.
Results: Forty-eight percent of subjects reported sufficient anxiety for anxiety disorder to be considered. At subsequent diagnostic interview, 18% fulfilled International Classification of Disorders, 10th Revision criteria for anxiety disorder, including 6% of patients who reported low levels of anxiety by questionnaire. When subjects reported anxiety by questionnaire, if disruptive somatic anxiety was present, this increased the probability of diagnosable anxiety disorder from .31 to .7. The most accurate screening questionnaires were the trait scale of the State-Trait Anxiety Inventory and the Hospital Anxiety and Depression scale. Female sex and negative aspects of social support were associated with anxiety disorder in multivariate analyses. Anxiety disorder was independently associated with a deficit in QOL, particularly insomnia.
Conclusion: Anxiety symptoms are common in cancer patients. Screening by questionnaire seems to assess anxiety symptoms adequately but discriminates abnormal anxiety inadequately. To improve this, we may need to use criteria such as disruption from anxiety, as illustrated by the impact of anxiety disorders on QOL. There seem to be few oncologic variables that could target screening for anxiety disorders. (C) 2002 by American Society of Clinical Oncology.
SN 0732-183X
PD JUL 15
PY 2002
VL 20
IS 14
BP 3137
EP 3148
UT ISI:000176920000014
ER

PT J
AU [Anon]
TI Swedish study examines how to predict anxiety and depression among cancer patients
SO EUROPEAN JOURNAL OF CANCER CARE
SN 0961-5423
PD JUN
PY 2002
VL 11
IS 2
BP 80
EP 80
UT ISI:000176643800012
ER

PT J
AU Smith, AB
Selby, PJ
Velikova, G
Stark, D
Wright, EP
Gould, A
Cull, A
TI Factor analysis of the Hospital Anxiety and Depression Scale from a large cancer population
SO PSYCHOLOGY AND PSYCHOTHERAPY-THEORY RESEARCH AND PRACTICE
AB The Hospital Anxiety and Depression Scale (HADS) is widely used as a tool for assessing psychological distress in patients and non-clinical groups. Previous studies have demonstrated conflicting results regarding the factor structure of the questionnaire for different groups of patients, and the general population. This study investigated the factor structure of the HADS in a large heterogeneous cancer population of 1474 patients. It also sought to investigate emerging evidence that the HADS conforms to the tripartite model of anxiety and depression (Clark & Watson, 1993), and to test the proposal that detection rates for clinical cases of anxiety and depression could be enhanced by partialling out the effects of higher order factors from the HADS (Dunbar et at, 2000). The results demonstrated a two-factor structure corresponding to the Anxiety and Depression subscales of the questionnaire. The factor structure remained stable for different subgroups of the sample, for males and females, as well as for different age groups, and a subgroup of metastatic cancer patients. The two factors were highly correlated (r=.52) and subsequent secondary factor analyses demonstrated a single higher order factor corresponding to psychological distress or negative affectivity. We concluded that the HADS comprises two factors corresponding to anhedonia and autonomic anxiety, which share a common variance with a primary factor namely psychological distress, and that the subscales of the HADS, rather than the residual scores (e.g. Dunbar et al., 2000) were more effective at detecting clinical cases of anxiety and depression.
SN 1476-0835
PD JUN
PY 2002
VL 75
PN Part 2
BP 165
EP 176
UT ISI:000176382600004
ER

PT J
AU Love, AW
Kissane, DW
Bloch, S
Clarke, DM
TI Diagnostic efficiency of the Hospital Anxiety and Depression Scale in women with early stage breast cancer
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
AB Objective: To investigate the diagnostic efficiency of the Hospital Anxiety and Depression Scale (HADS) in patients with breast cancer.
Methods: Women (303) recently diagnosed with stage I or II breast cancer completed the HADS and were psychiatrically assessed. Recommended cut-off scores for Depression (D) and Anxiety (A) Scales identified probable caseness and the accuracy was compared with DSM-IV diagnoses. Cut-off scores were varied to establish optimal accuracy.
Results: One hundred and eleven (36.6%) met criteria for depressive disorders and 25 (8.3%) met criteria for anxiety disorders. At the recommended cut-off score of 11 for the D scale, positive and negative predictive values were .75 and .64, respectively, while sensitivity and specificity were .05 and .99, respectively. For the A scale, positive predictive value (PPV) was .15; negative predictive value (NPV), .90; sensitivity, .08; and specificity, .87. Reducing the cut-off score to 5 produced PPV of .63, NPV of .74, sensitivity of .49 and specificity of .83 for the D scale; .14, .94, .75 and .45, respectively, for the A scale. Composite scores (cut-off of 22) had a PPV of .92, NPV of .57, sensitivity of .09 and specificity of .99.
Conclusions: Recommended cut-off scores for the HADS may result in under-reporting of psychiatric morbidity among women with early stage breast cancer. These results are consistent with other recent studies of the HADS. The type of constructs measured by the scale is the likely explanation for its limited utility when screening for psychiatric morbidity in early stage breast cancer.
SN 0004-8674
PD APR
PY 2002
VL 36
IS 2
BP 246
EP 250
UT ISI:000175762900014
ER

PT J
AU Rossi, GB
De Bellis, M
Marone, P
Tempesta, AM
Monsurro, MR
TI Acceptable levels of anxiety and depression are induced by genetic testing in hereditary nonpolyposis colorectal cancer family members
SO GASTROINTESTINAL ENDOSCOPY
SN 0016-5107
PD APR
PY 2002
VL 55
IS 5
SU Suppl. S
BP AB215
EP AB215
UT ISI:000175348700517
ER

PT J
AU Mykletun, A
Foss, S
Dahl, AA
TI Disability pension in surviving cancer-patients: the influence of anxiety and depression on risk for disability pension
SO ACTA PSYCHIATRICA SCANDINAVICA
SN 0001-690X
PY 2002
VL 105
SU Suppl. 411
BP 23
EP 23
UT ISI:000175484700052
ER

PT J
AU Hjerl, K
Andersen, EW
Keiding, N
Mortensen, PB
Jorgensen, T
TI Increased incidence of affective disorders, anxiety disorders, and non-natural mortality in women after breast cancer diagnosis: a nation-wide cohort study in Denmark
SO ACTA PSYCHIATRICA SCANDINAVICA
AB Objective: To investigate whether breast cancer patients have increased incidence of psychiatric admission with affective disorders. anxiety disorders, or non-natural mortality compared with the general female population,
Method: Register-linkage between nation-wide registries: The Danish Psychiatric Central Register, The Danish Cancer Registry, and The Danish National Register of Causes of Death. A total of 61 709 women registered with primary invasive breast cancer between 1970 and 1993 were included and 356 023 person-years were accrued.
Results: The standardized incidence ratio of first-ever psychiatric admission with affective disorder was 1.49 (95% CI: 1.35-1.63) and with anxiety disorder 1.25 (95% CI: 1.06-1.46). The standardized nonnatural mortality ratio during the first year after breast cancer diagnosis was 1.54 (95% Cl: 1.27-1.87). All analyses were adjusted for age. calendar period, and place of residence.
Conclusion: Breast cancer patients have significantly increased incidence of psychiatric admission with affective disorders, anxiety disorders, and non-natural mortality.
SN 0001-690X
PD APR
PY 2002
VL 105
IS 4
BP 258
EP 264
UT ISI:000174880500004
ER

PT J
AU Roth, AJ
Rosenfeld, B
Kornblith, A
Gibson, C
Scher, H
Holland, JC
Breitbart, WS
TI The memorial anxiety scale for prostate cancer (MAX-PC): Validation of a new scale to measure anxiety in men with prostate cancer
SO PSYCHOSOMATICS
SN 0033-3182
PD MAR-APR
PY 2002
VL 43
IS 2
BP 158
EP 159
UT ISI:000174530300049
ER

PT J
AU Devine, D
Sterner, J
Parker, P
Basen-Engquist, K
de Moor, C
Fitzgerald, M
Cohen, L
TI Social aspects of religiosity predict reductions in anxiety for women undergoing treatment for ovarian cancer
SO PSYCHOSOMATIC MEDICINE
SN 0033-3174
PD JAN-FEB
PY 2002
VL 64
IS 1
BP 122
EP 122
UT ISI:000173760200175
ER

PT J
AU Hurley, K
Du Hamel, K
Vickberg, S
Seremetis, S
TI Does cancer-specific anxiety facilitate or deter screening? Different answers from breast and colon cancer screening
SO PSYCHOSOMATIC MEDICINE
SN 0033-3174
PD JAN-FEB
PY 2002
VL 64
IS 1
BP 157
EP 157
UT ISI:000173760200342
ER

PT J
AU Fossa, SD
Dahl, AA
TI Short Form 36 and Hospital Anxiety and Depression Scale - A comparison based on patients with testicular cancer
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
AB Background: The aim of this study was to compare the scorings of anxiety and depression assessed by the Hospital Anxiety and Depression Scale (HADS-A [Anxiety] and HADS-D [Depression]) with the scorings on the eight subscales of Short Form 36 (SF-36) and the Physical (PCS) and Mental Component Summary (MCS) assessed by the same patients. Method: In a cross-sectional study 736 long-term survivors after treatment for testicular cancer (TC) completed HADS and SF-36. Pearson's correlation coefficients were calculated on item and scale level to assess the associations between the HADS and the SF-36 scales and, in particular, between HADS and PCS and MCS, respectively. Independent predictors for PCS and MCS were identified by linear regression analysis. Results: HADS-A and HADS-D were significantly associated with the SF-36 summary scales. HADS-A explained 5% of the variance of PCS and 49% of the variance of MCS. The comparable figures for HADS-D were 10% and 45%, respectively. In the multivariate analysis the HADS-D scoring independently predicted the level of PCS together with the patients' educational level, long-lasting working disability and age (variance: 30%). Both HADS-D and HADS-A remained independent parameters for MCS (variance: 58%) together with the patient's civil status. HADS-D item D4 ("slowed down") was similarly associated with both PCS and MCS. Conclusion: In univariate analyses HADS-D and HADS-A were statistically associated with PCS and MCS. The highest r values were observed for the associations between HADS and MCS, in particular between HADS-A and MCS. In the multivariate analyses HADS-D, but not HADS-A, contributed to PCS, whereas both HADS-A and HADS-D were associated with MCS. This pattern of different predictions of the summary scales of SF-36 supports a clinical practice that anxiety and depression should be assessed separately. Additional use of a self-rating instrument for depression and anxiety, such as HADS, is recommended when SF-36 is used for quality of life (QL) assessment. (C) 2002 Elsevier Science Inc. All rights reserved.
SN 0022-3999
PD FEB
PY 2002
VL 52
IS 2
BP 79
EP 87
UT ISI:000173932200004
ER

PT J
AU Kollbrunner, J
Zbaren, P
Quack, K
TI Quality of life burden of patients with large tumor of the oral cavity. A descriptive study of psychological effects of disease and primary surgical therapy in 3 parts. Part 2: Working through the illness: coping, anxiety, depression
SO HNO
AB The psychosocial effects of disfigurements and dysfunctions after combined surgical and radio-oncological therapy of patients with large tumors of the oral cavity (n=50) are investigated in a three-part study. Part 1 compared the "limitations of quality of life" (LQL) of these patients with those of patients after total laryngectomy (n=34) and with a group of patients "without cancer"(n=40).
This second part records the coping strategies of the three groups of patients and relates them to the following variables: anxiety (STAI), depression (D-S'), despair (H-scale), self-image (GT), locus of control (KKG), intellectual capacity (shortend SPM) and psychosocial burden in early childhood (new questionnaire). The coping strategies of "compliance" and "self-encouragement" were used most often. Patients with a higher psychosocial burden in early childhood often chose defensive strategies (distrust, cognitive avoidance, distraction, reinforced control of emotions). Only few patients used strategies of healthy regression ("coasting values", A. Maslow). It seems that no specific single coping strategy (in particular not the frequently recommended "positive thinking") but an individualized selection of different strategies is of special value to patients. The self-esteem of the patient was identified as a crucial factor in increasing the effectiveness of coping strategies. The surgeon can support patients in their self-esteem by showing a genuine interest not only in their state of health but also in their personal background.
The third part of the study is focused on a search for variables which could serve as preoperative indicators of the individual ability to bear the burden of illness and therapy.
SN 0017-6192
PD DEC
PY 2001
VL 49
IS 12
BP 998
EP 1007
UT ISI:000173387600003
ER

PT J
AU Mu, PF
Ma, FC
Hwang, B
Chao, YM
TI Families of children with cancer: The impact on anxiety experienced by fathers
SO CANCER NURSING
AB By using the contextual model of family stress, this study examined fathers' family stress experience when caring for a child receiving cancer treatments. A descriptive correlational study was designed to examine the relationships between fathers' uncertainty, sense of mastery, and anxiety. Eighty fathers were recruited from two teaching hospitals in Taiwan. A pilot study was conducted to establish the reliability and validity of the Chinese language version of the above instruments. These instruments showed an acceptable internal consistency and satisfactory construct validity. Results showed that fathers' level of education had a significant effect on paternal anxiety. Uncertainty and fathers' education level equal to or higher than university are good predictors of paternal anxiety, which explain 25% of the variance. The results provide insight into the paternal experience of family stress and suggest ways to improve family-centered nursing interventions and thereby establish better family well-being.
SN 0162-220X
PD FEB
PY 2002
VL 25
IS 1
BP 66
EP 73
UT ISI:000173712200009
ER

PT J
AU Montazeri, A
Jarvandi, S
Haghighat, S
Vahdani, M
Sajadian, A
Ebrahimi, M
Haji-Mahmoodi, M
TI Anxiety and depression in breast cancer patients before and after participation in a cancer support group
SO PATIENT EDUCATION AND COUNSELING
AB A prospective study was conducted to assess the long-term impact of attending a support group on the prevalence of psychological morbidity in patients with breast cancer before and after 1-year participation in the Iranian breast cancer support group. Psychological morbidity was measured using the hospital anxiety and depression scale (HADS). In addition, qualitative data were collected to throw some lights on the topic. All current members of the three Iranian breast cancer support groups (n = 56) were interviewed. The mean age of patients was 45.4 (S.D. = 9.2) years, most were married (n = 46, 82%), and 54% of patients (n = 30) were diagnosed as having breast cancer from 1 to 5 years ago. While at baseline 16 patients (29%) scored high on the anxiety sub-scale and eight patients (14%) scored high on the depression sub-scale, at follow-up only two patients (2%) were likely experiencing severe anxiety symptoms and there were no patients with probable severely depressed mood. Comparing anxiety and depression at baseline and follow-up, there was a statistically significant difference between baseline and follow-up anxiety (P = 0.03) and depression (P = 0.008) scores. Analysis of the qualitative data indicated that the group involvement was the most important factor that contributed to the patients' improved psychological wellbeing. The findings of this prospective study suggest that participation in cancer support groups could have a long-term effect in reducing anxiety and depression in breast cancer survivors. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
SN 0738-3991
PD DEC 1
PY 2001
VL 45
IS 3
BP 195
EP 198
UT ISI:000172639900005
ER

PT J
AU Lloyd-Williams, M
Friedman, T
Rudd, N
TI An analysis of the validity of the Hospital Anxiety and Depression scale as a screening tool in patients with advanced metastatic cancer
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
AB Depression is difficult to diagnose in the terminally ill patient. As a result, it frequently is not treated. This has can have an adverse effect on quality of life and make the palliation of physical symptoms mare difficult. In an effort to improve the detection of depression, many palliative care teams are using the Hospital Anxiety and Depression (HAD) scale as a screening tool. The HAD was devised for use in general medical settings and has not been validated for use in palliative care patients. One hundred patients receiving palliative cape with an estimated prognosis of 6 months or less were invited to complete the HAD and a semistructured psychiatric interview, the Present State Examination. The depression and anxiety subscales of the HAD showed poor efficacy for screening when used alone. The optimum threshold was at a combined cut-off of 19, which had a sensitivity of 68% and specificity of 67%. The major construct of the HAD is anhedonia, which may be present at the end of life due to increasing physical illness and may not be pathognomic of a depressive illness in this population.. We recommend, therefore, that if the HAD is used as a screening tool in palliative care, it should be as a combined scale, but low sensitivity and specificity may lead to poor efficacy as a screening tool. (C) U.S. Cancer Pain Relief Committee, 2001.
SN 0885-3924
PD DEC
PY 2001
VL 22
IS 6
BP 990
EP 996
UT ISI:000172656300002
ER

PT J
AU Neto, JP
Massoco, CO
Favare, RC
TI Effects of maternal stress on anxiety levels, macrophage activity, and Ehrlich tumor growth
SO NEUROTOXICOLOGY AND TERATOLOGY
AB The present study analyzed the effects of maternal stress on behavior and immune function of mice. Pregnant mice received a daily footshock (0.4 mA) from gestational day 15 (GD 15) to GD 19. Experiments were performed on male offspring aged 2 months. The following results were obtained for offspring from dams stressed during pregnancy: (1) decreased locomotor activity observed in the open-field central zone; (2) decreased number of entries into the open arms of the plus-maze and decreased time spent in the exploration of these arms; (3) decreased macrophage spreading and phagocytosis, but no changes in macrophage NO2- production, (4) increased growth of both the ascitic and solid forms of Ehrlich tumor. These changes were unrelated to differences in gestational parameters and did not reflect altered maternal-pup interactions or nutritional factors. The observed data provide experimental evidence that maternal stress alters stress/anxiety levels, macrophage activity and Ehrlich tumor growth at the same time and in the same litter. The data were discussed in the light of possible neuroendocrine-immune system interactions. (C) 2001 Elsevier Science Inc. All rights reserved.
SN 0892-0362
PD SEP-OCT
PY 2001
VL 23
IS 5
BP 497
EP 507
UT ISI:000172291800012
ER

PT J
AU Nordin, K
Wasteson, E
Hoffman, K
Glimelius, B
Sjoden, PO
TI Discrepancies between attainment and importance of life values and anxiety and depression in gastrointestinal cancer patients and their spouses
SO PSYCHO-ONCOLOGY
AB Patients' satisfaction with life, viewed in terms of the discrepancy between the perceived attainment and subjective importance of various life values, is a less often studied phenomenon for understanding the psychological adaptation in cancer patients. The main aim of the present study is to investigate the relation between the degree of attainment and importance of life values on the one hand, and anxiety and depression, on the other. A consecutive series of 85 newly diagnosed patients with gastrointestinal (GI) cancers, 52 potentially cured and 33 with an advanced disease, and 26 spouses to the patients with an advanced disease participated. The patients and spouses of non-cured patients filled out questionnaires twice, close to the diagnosis and after 1 (non-cured patients) or 3 months. Overall, large discrepancies between the perceived attainment and importance of life values were associated with high anxiety and depression. For the patients (both cured and non-cured), the discrepancies decreased for several life values over time, as did anxiety and depression. For the spouses of the non-cured patients, there was no decrease either for life value discrepancies or for anxiety/depression. This suggests that patients, in contrast to their spouses, strive to achieve small discrepancies between the perceived attainment and importance of life values, as part of their adjustment to serious diseases, e.g. cancer. Copyright (C) 2001 John Wiley & Sons, Ltd.
SN 1057-9249
PD NOV-DEC
PY 2001
VL 10
IS 6
BP 479
EP 489
UT ISI:000172156400003
ER

PT J
AU Tashiro, M
Itoh, M
Kubota, K
Kumano, H
Masud, MM
Moser, E
Arai, H
Sasaki, H
TI Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients: A preliminary pet study
SO PSYCHO-ONCOLOGY
AB The purpose of this study is to examine the relationship between psychological factors, regional brain activity and natural killer cell activity (NTKA). Eight patients with malignant diseases were studied by FDG-PET under a resting condition. NKA and degree of anxiety and depression were measured using Taylor's manifest anxiety scale (MAS) and Zung's self-rating depression scale (SDS). Linear correlation of NKA and psychological measures to the regional brain metabolism in cancer patients was examined using statistical parametric mapping (SPM).
Positive linear correlation between NKA and regional metabolic rate ratios was identified in the visual association cortex, anterior cingulate gyrus (CG) and sensorimotor area, and negative correlation was identified in the inferolateral prefrontal cortex (ILPFC), prefrontal cortex (PFC), orbitofrontal cortex (OFC) and anterior temporal cortex. Positive linear correlation to the MAS score was identified in the visual association cortex, anterior CG, primary sensorimotor area and the posterior parietal cortex, and negative correlation was detected in the ILPFC, PFC, OFC and anterior temporal cortex. The NKA and MAS scores positively correlated with each other (p < 0.001).
The result might serve as supporting data for a hypothesis that psycho-immune interaction is also mediated by the cerebral cortex and limbic system. Copyright (C) 2001 John Wiley & Sons, Ltd.
SN 1057-9249
PD NOV-DEC
PY 2001
VL 10
IS 6
BP 541
EP 546
UT ISI:000172156400009
ER

PT J
AU Geinitz, H
Zimmermann, FB
Stoll, P
Thamm, R
Ansorg, K
Keller, M
Molls, M
TI Correlation of fatigue, anxiety and depression during radiotherapy of breast cancer patients
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUL-AUG
PY 2001
VL 10
IS 4
SU Suppl. S
BP S27
EP S27
UT ISI:000170484700046
ER

PT J
AU Vollmer, TC
TI The reducing effect of bibliotherapy on cancer patients general anxiety and mood state
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUL-AUG
PY 2001
VL 10
IS 4
SU Suppl. S
BP S49
EP S50
UT ISI:000170484700111
ER

PT J
AU Nordin, K
Wasteson, E
Hoffman, K
Glimelius, B
Sjoden, PO
TI Discrepancies between attainment and importance of life values and anxiety and depression in gastrointestinal cancer patients and their spouses
SO PSYCHO-ONCOLOGY
SN 1057-9249
PD JUL-AUG
PY 2001
VL 10
IS 4
SU Suppl. S
BP S85
EP S85
UT ISI:000170484700198
ER

PT J
AU Stark, D
Kiely, M
Smith, A
Selby, P
House, A
TI Anxiety in cancer patients.
SO BRITISH JOURNAL OF CANCER
SN 0007-0920
PD JUL
PY 2001
VL 85
SU Suppl. 1
BP 65
EP 65
UT ISI:000170065300243
ER

PT J
AU Fujii, M
Ohno, Y
Tokumaru, Y
Imanishi, Y
Kanke, M
Tomita, T
Kanzaki, J
TI Manifest Anxiety Scale for evaluation of effects of granisetron in chemotherapy with CDDP and 5FU for head and neck cancer
SO SUPPORTIVE CARE IN CANCER
AB The level of anxiety was examined before treatment by means of the Manifest Anxiety Scale (MAS) in 41 patients with squamous cell carcinoma of the head and neck. They received 5 days of neoadjuvant chemotherapy with cisplatin (CDDP) and 5-fluorouracil (5FU). Granisetron (KYT) was administered daily from day I to day 5. Nausea, vomiting, appetite, and well-being were assessed during and after chemotherapy. The relation between the effects of KYT and anxiety was studied. Seventeen patients were proven to have anxiety and were compared with the other 24 patients. In patients with anxiety, the percentage wellbeing was significantly lower on days 1 and 2 (P=0.008, 0.001). The rate of freedom from nausea was significantly lower from day 4 to day 9 for anxiety patients (P=0.010 similar to0.050). The percentage of anxiety patients without loss of appetite was significantly lower from day 6 to 9 (p = 0.001 similar to 0.020). The rate of freedom from vomiting was significantly lower on days 4, 5 and 7 for anxiety patients (P = 0.024, 0.024, 0.014). The results indicate that the effect of KYT was significantly lower from day 3 to day 7 for anxiety patients (P = 0.008 similar to 0.045). The anxiety group had significantly poorer well-being at the beginning of chemotherapy, and were not responsive to KYT in the delayed phase. Our results prove that anxiety patients show delayed emesis, and the administration of KYT is considered insufficient. It may be important to co-administer a tranquilizer to any patient who exhibit anxiety as defined by the MAS, in order to reduce delayed emesis.
SN 0941-4355
PD JUL
PY 2001
VL 9
IS 5
BP 366
EP 371
UT ISI:000170133500008
ER

PT J
AU D'Haese, S
Vinh-Hung, V
Bijdekerke, P
Spinnoy, M
De Beukeleer, M
Lochie, N
De Roover, P
Storme, G
TI The effect of timing of the provision of information on anxiety and satisfaction of cancer patients receiving radiotherapy
SO JOURNAL OF CANCER EDUCATION
AB Background. To improve the provision of information to their radiotherapy patients, the authors examined whether the timing of given written information has an effect on anxiety and satisfaction. Methods. Two sources of information were used: 1) a booklet with a description of radiotherapy procedures and the sensations patients can experience; 2) teaching sheets with treatment, site-related information. 68 patients were randomized to a simultaneous- information group (n = 31) and a stepwise- information group (n = 37). The patients were being treated for cancers of the breast, lung, head, and neck or the pelvic region. The authors analyzed the impacts of several variables on patient learning, including anxiety, age, gender, support, referral, stage of illness, and diagnosis. Assessments were recorded before the simulation procedure and during the second and last weeks of treatment. Results. The stepwise-information group was significantly less anxious before simulation (p = 0.02) and more satisfied (p = 0.001). Of the variables studied, only the support variable was associated with high state anxiety (p < 0.0001). Conclusions. Provision of patient information in a stepwise format leads to less treatment-related anxiety and greater patient satisfaction among radiation therapy patient undergoing simulation.
SN 0885-8195
PD WIN
PY 2000
VL 15
IS 4
BP 223
EP 227
UT ISI:000170236800009
ER

PT J
AU Smith, EL
Hann, DM
Ahles, TA
Furstenberg, CT
Mitchell, TA
Meyer, L
Maurer, H
Rigas, J
Hammond, S
TI Dyspnea, anxiety, body consciousness, and quality of life in patients with lung cancer
SO JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
AB Dyspnea is a common symptom of lung cancer that can impact patient physical, social, and psychological well-being Study goals were to evaluate quality of life (QOL) and dyspnea in;patients with lung cancer and the relationships between QOL, dyspnea, trait anxiety, and body consciousness. Sociodemographic and cancer-related variables (stage, cell type, performance status) were evaluated. One hundred twenty outpatients with stage I-IV lung cancer participated in the study. Patients completed 5 questionnaires assessing QOL, dyspnea, trait anxiety body consciousness, and pain. Eighty-seven percent of study participants experienced dyspnea. Patients with high dyspnea scores had lower QOL (P = 0. 04). Dyspnea was worse in men than in women (P 0.02), and there was a trend towards older patients reporting more severe dyspnea than younger patients (P = 0. OG). There was no difference in dyspnea based on cancer stage, cell type, or performance status. Pain and anxiety scores were higher in patients with high dyspnea (P = 0. 02, P = 0. 03). Dyspnea was more se(,ere in patients taking opioid analgesics when compared to non-opioids or no pain medications (P = 0. 03). No significant association was found between dyspnea, anxiety, and private body consciousness. (C) U.S. Cancer Pain Relief Committee, 2001.
SN 0885-3924
PD APR
PY 2001
VL 21
IS 4
BP 323
EP 329
UT ISI:000168042500010
ER

PT J
AU Hurley, KE
Miller, SM
Costalas, JW
Gillespie, D
Daly, MB
TI Anxiety/uncertainty reduction as a motivation for interest in prophylactic oophorectomy in women with a family history of ovarian cancer
SO JOURNAL OF WOMENS HEALTH & GENDER-BASED MEDICINE
AB Most women at familial risk for ovarian cancer must decide about prophylactic oophorectomy without conclusive genotypic information about their risk level. Some women with relatively low-risk profiles seek prophylactic oophorectomy or are recommended the procedure by their physicians, if they appear "cancerphobic." This study investigated the desire to reduce anxiety in relation to other factors associated with interest in prophylactic oophorectomy in a group of women with varying degrees of familial risk for ovarian cancer. Ninety-four women enrolled in an ongoing program for women with a family history of ovarian cancer received personalized risk counseling and were classified as having a sporadic, familial, or putative hereditary pedigree by a genetics counselor. Eligible enrollees were interviewed by telephone about current and future interest in prophylactic oophorectomy, perceived risk of ovarian cancer, severity of cancer anxiety, stress-related ideation, and reasons for and against surgery. Reduction of anxiety/uncertainty was the factor most strongly associated with current interest in prophylactic oophorectomy, independent of objective risk classification, perceived risk, severity of cancer anxiety, intrusive ideation, or other variables. Future interest in prophylactic oophorectomy was predicted by other perceived benefits of surgery. Current, but not future, interest in prophylactic oophorectomy appears motivated in part by seeking immediate relief from anxiety. Interest in prophylactic oophorectomy may fluctuate based on varying exposure to cues that trigger anxiety. Women seeking prophylactic oophorectomy, particularly those with lower-risk family pedigrees, should be offered options for anxiety management as part of informed consent for prophylactic oophorectomy.
SN 1524-6094
PD MAR
PY 2001
VL 10
IS 2
BP 189
EP 199
UT ISI:000167730900010
ER

PT J
AU Dropkin, MJ
TI Anxiety, coping strategies, and coping behaviors in patients undergoing head and neck cancer surgery
SO CANCER NURSING
AB Background: Little is reported in the scientific literature about the modulating effect of anxiety on the coping process before and after surgical treatment for head and neck cancer.
Objectives: The major purpose of this article is to describe the relationships among preoperative anxiety and use of coping strategies, and postoperative self-care and resocialization behaviors in patients who sustain facial disfigurement/dysfunction with head and neck cancer surgery
Methods: Using a prospective descriptive design, 75 (N = 75) adults who were about to sustain facial disfigurement and dysfunction associated with head and neck cancer surgery were entered into the study. The State Trait Anxiety Inventory and the Ways of Coping Questionnaire were administered to the respondents. The Disfigurement/Dysfunction Scale and Coping Behaviors Score values were calculated by the investigator.
Results: Self-care and anxiety were significantly correlated on postoperative day 4 (r = 2.30; p < .05) and on postoperative day 5 (r = 2.35; p < .05). For the 3 days under study the relationship between total self-care and anxiety became stronger on postoperative day 5 (r = 2.39; p < .01), indicating that self-care on postoperative day 4 is related to reduced anxiety on postoperative day 5. In other words, self-care appears to precede reduction in anxiety in this sample. Secondly, there was a negative relationship between self-care and anxiety that increased over the early postoperative period.
Conclusions: This study prospectively documents anxiety in surgical head and neck cancer patients. The findings suggest that at a specific point in time (postoperative day 5), self-care precedes reduction in anxiety and that this negative relationship increases over time. Additional investigation is now critical in order to describe long-term recovery after surgical treatment for head and neck cancer and to develop appropriate interventions to meet the unique needs of this population.
SN 0162-220X
PD APR
PY 2001
VL 24
IS 2
BP 143
EP 148
UT ISI:000167818600009
ER

PT J
AU Lampic, C
Thurfjell, E
Bergh, J
Sjoden, PO
TI Short- and long-term anxiety and depression in women recalled after breast cancer screening
SO EUROPEAN JOURNAL OF CANCER
AB The aim was to investigate the psychological consequences of further investigation after breast cancer screening. Study participants include 509 women (61%) recalled due to suspicious findings on screening mammograms, and a matched control group of 285 women (68%) with normal mammograms. Psychological distress was prospectively assessed with the Hospital Anxiety and Depression Scale (HADS). 46% of the women reported borderline or clinically significant anxiety prior to the recall visit. A few days after the visit, anxiety and depression had decreased significantly (P < 0.01) in women informed about normal or benign results at the recall clinic, while reported distress remained at relatively high levels in women referred to surgical biopsy. The results demonstrate the adverse short-term effect of a delay in receiving false-positive results, but do not indicate that the recall experience results in long-term anxiety or depression for a majority of women. <(c)> 2001 Elsevier Science Ltd. All rights reserved.
SN 0959-8049
PD MAR
PY 2001
VL 37
IS 4
BP 463
EP 469
UT ISI:000167739600015
ER

PT J
AU Nordin, K
Berglund, C
Glimelius, B
Sjoden, PO
TI Predicting anxiety and depression among cancer patients: a clinical model
SO EUROPEAN JOURNAL OF CANCER
AB The aim of this study was to investigate the possibility of predicting anxiety and depression 6 months after the cancer diagnosis on the basis of measures of anxiety, depression (Hospital Anxiety and Depression, HAD scale), subjective distress (Impact of Event, IES scale) and some aspects of social support in connection with the diagnosis. A further purpose was to attempt identification of individual patients at risk of prolonged psychological distress, and to develop an easily applicable clinical tool for such detection. A consecutive population-based series of 522 newly diagnosed patients with breast, colorectal, gastric and prostate cancer were interviewed in connection with the diagnosis and 6 months later. Anxiety and depression close to the diagnosis explained 39% of the variance in anxiety and depression 6 months later. Patients scoring as doubtful cases/cases for HAD anxiety and/or depression were more than 11 times more likely than non-cases to score as doubtful cases/cases at 6 months. Addition:ll risk factors were having an advanced disease and nobody in addition to the family to rely on in case of difficulties. Levels of anxiety and depression at diagnosis predict a similar status 6 months later. The results also indicate that the HAD scale in combination with a single question about social support may be a suitable screening tool for clinical use. (C) 2001 Elsevier Science Ltd. All rights reserved.
SN 0959-8049
PD FEB
PY 2001
VL 37
IS 3
BP 376
EP 384
UT ISI:000167269200019
ER

PT J
AU Williams, B
Loughlin, M
Meagher, T
Williams, SJ
TI The use of the named nurse to minimise anxiety and maximise patient communication in the rapid diagnosis of suspected lung cancer
SO THORAX
SN 0040-6376
PD DEC
PY 2000
VL 55
SU Suppl. 3
BP A88
EP A88
UT ISI:000165784000350
ER

PT J
AU Stark, DPH
House, A
TI Anxiety in cancer patients
SO BRITISH JOURNAL OF CANCER
AB Anxiety is common in cancer patient populations, and must often initially be recognized and managed by cancer care professionals. This article reviews the recent oncology and mental health literature on anxiety. The aim is to help those involved in cancer patient care who are not specialists in mental health to understand the nature of anxiety, and discriminate morbid from normal anxiety. We review recent research into the association of anxiety with events during diagnosis and management of cancer, highlighting the importance of the meaning of events to an individual as an important factor in making people anxious. Lastly we review management strategies which might be used by cancer care professionals, in particular the importance of an awareness of specific patterns of communication which may alleviate or maintain anxiety for some cancer patients. (C) 2000 Cancer Research Campaign.
SN 0007-0920
PD NOV
PY 2000
VL 83
IS 10
BP 1261
EP 1267
UT ISI:000165213800001
ER

PT J
AU Montazeri, A
Harirchi, I
Vahdani, M
Khaleghi, F
Jarvandi, S
Ebrahimi, M
Haji-Mahmoodi, M
TI Anxiety and depression in Iranian breast cancer patients before and after diagnosis
SO EUROPEAN JOURNAL OF CANCER CARE
AB A prospective study was conducted to measure anxiety and depression in Iranian breast cancer patients before and after diagnosis using the Hospital Anxiety and Depression Scale (HADS). The HADS was administered at two points in time: before diagnosis and 3 months after. In all, 168 breast cancer patients were interviewed. While 48% of patients had severe symptoms of anxiety at both baseline and follow-up, more than 60% of patients had no symptoms of depressive illness at pre-and post-diagnosis assessments. Comparing anxiety and depression before diagnosis and after 3 months, there were no significant differences between patients' scores on anxiety (P = 0.42) and depression (P = 0.98) subscales. The results showed that patients with advanced disease and a lower performance status were more anxious and experienced more depression. The study findings suggest that severe symptoms of anxiety are the most frequent symptoms in Iranian breast cancer patients. It seems that during the process of diagnosis and 3 months after psychological morbidity persists in patients who suffer from breast cancer.
SN 0961-5423
PD SEP
PY 2000
VL 9
IS 3
BP 151
EP 157
UT ISI:000090132000020
ER

PT J
AU Skarstein, J
Aass, N
Fossa, SD
Skovlund, E
Dahl, AA
TI Anxiety and depression in cancer patients: relation between the Hospital Anxiety and Depression Scale and the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
AB Background: The emotional functioning (EF) dimension of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ C33) and the Hospital Anxiety and Depression Scale (HADS) evaluate anxiety and depression. We wanted to compare cancer patients' responses to EF with those to HADS, as well as the impact of anxiety and depression on the quality of life (QL) dimensions of the EORTC QLQ C33. Method: A total of 568 cancer patients completed both the EORTC QLQ C33 and HADS at the same occasion. The association between the patients' EF scorings and their HADS scores was analyzed by multiple linear regression. Gender and age were included as covariates. Results: Statistically significant negative relations were found between EF and HADS-A (anxiety), HADS-D (depression) and HADS-T (total score), respectively, with the highest correlation coefficient for HADS-A. Older patients and males reported less emotional distress assessed by the EF scale than younger ones and females with comparable HADS-T or HADS-D scores. Both HADS-A and HADS-D were significantly related to other QL dimensions, and depression was a stronger predictor for reduced QL than anxiety. Conclusion: The EF dimension of EORTC QLQ C33 predominantly assesses anxiety, whereas depression is rated to a lesser degree. Combined with significant age and gender relations, this implies a risk of underdiagnosed depression, if the EORTC QLQ C33 is used as the only instrument to screen for psychological distress in cancer patients. As depression has a stronger impact on global QL of cancer patients than anxiety, the use of an additional instrument is recommended for assessment of depression. (C) 2000 Elsevier Science Inc. All rights reserved.
SN 0022-3999
PD JUL
PY 2000
VL 49
IS 1
BP 27
EP 34
UT ISI:000090067700006
ER

PT J
AU Shere, MH
TI Family histories of cancer in primary care - Referrals might be made on the basis of women's anxiety
SO BRITISH MEDICAL JOURNAL
SN 0959-8138
PD OCT 14
PY 2000
VL 321
IS 7266
BP 955
EP 955
UT ISI:000089975100035
ER

PT J
AU Bodurka-Bevers, D
Basen-Engquist, K
Carmack, CL
Fitzgerald, MA
Wolf, JK
de Moor, C
Gershenson, DM
TI Depression, anxiety, and quality of life in patients with epithelial ovarian cancer
SO GYNECOLOGIC ONCOLOGY
AB Objective. The aims of this study were to evaluate psychological distress and quality of life (QOL) in patients with epithelial ovarian cancer (EOC) and to examine the relationship between these problems and health and demographic variables.
Methods. Of 344 consecutive patients identified, 246 completed questionnaires. Four dimensions of QOL were assessed including physical, functional, emotional, and social/family well-being, as well as concerns specific to ovarian cancer patients. Depression was measured with the Center for Epidemiologic Studies-Depression (CES-D) scale and anxiety was measured by the State Anxiety Subscale of the Spielberger State-Trait Anxiety Inventory. Performance status was evaluated by the Zubrod score.
Results. Sixty-five patients (26%) had early stage disease; 181 (74%) had advanced disease. One hundred twenty-one patients (49%) were under active treatment, while 124 (51%) were seen for posttherapy surveillance. Forty-eight (21%) met CES-D cutoff criteria for a clinical evaluation for depression, and 29% scored above the 75th percentile for anxiety. Performance status was related to depression, anxiety, and QOL problems, except in the domain of social well-being.
Conclusions. Clinically significant depression and anxiety may be more prevalent in patients with EOC than previously reported. Future studies of screening for and treating psychological distress are being designed to improve QOL in these women. (C) 2000 Academic Press.
SN 0090-8258
PD SEP
PY 2000
VL 78
IS 3
PN Part 1
BP 302
EP 308
UT ISI:000089317000006
ER

PT J
AU Von Essen, L
Enskar, K
Kreuger, A
Larsson, B
Sjoden, PO
TI Self-esteem, depression and anxiety among Swedish children and adolescents on and off cancer treatment
SO ACTA PAEDIATRICA
AB Self-esteem, depression and anxiety were investigated in 51 Swedish children and adolescents, 8-18 y, on (n = 16) and off (n = 35) cancer treatment. The self-report measures "I Think I Am" (ITIA), the Children's Depression Inventory (CDI) and the Revised Children's Manifest Anxiety Scale (RCMAS) were used. Data were compared with data previously obtained by others for healthy Swedish children. Children and adolescents on treatment showed levels of self-esteem, depression and anxiety comparable to those of healthy children. However, children and adolescents off treatment reported higher depression and anxiety levels and lower psychological well-being and physical self-esteem than have been reported for healthy Swedish children. Seven children (14%) reported a high level of depression, six of whom were off treatment. The findings suggest that the period after treatment termination is characterized by a higher risk of psychosocial problems than is the actual treatment period.
SN 0803-5253
PD FEB
PY 2000
VL 89
IS 2
BP 229
EP 236
UT ISI:000085499900023
ER

PT J
AU Weihs, KL
TI Disease severity, chronic anxiety, emotional constraint and emotional style fail to predict time from breast cancer diagnosis to recurrence diagnosis
SO PSYCHOSOMATIC MEDICINE
SN 0033-3174
PD JAN-FEB
PY 2000
VL 62
IS 1
BP 135
EP 136
UT ISI:000085423800210
ER

PT J
AU Svedlund, J
Sullivan, M
Liedman, B
Lundell, L
TI Experience of anxiety and tension predicts tumor status in patients facing surgery for gastric cancer
SO PSYCHOSOMATIC MEDICINE
SN 0033-3174
PD JAN-FEB
PY 2000
VL 62
IS 1
BP 148
EP 148
UT ISI:000085423800271
ER

PT J
AU Challinor, JM
Miaskowski, CA
Franck, LS
Slaughter, RE
Matthay, KK
Kramer, RF
Veatch, JJ
Paul, SM
Amylon, MD
Moore, IM
TI Somatization, anxiety and depression as measures of health-related quality of life of children/adolescents with cancer
SO INTERNATIONAL JOURNAL OF CANCER
AB This descriptive study of health-related quality of life of children with cancer compared children/adolescents', parents' and teachers' ratings for somatization, depression and anxiety to determine if there were significant correlations among respondent scores. In addition, the percentage of agreement among respondents and significant differences based on age, gender, use of cranial radiation and treatment status were measured, Forty-three children/adolescents with cancer, currently receiving therapy for at least 1 year or who had completed therapy for no more than 3 years (excluding children who had received bone marrow transplants or who had brain tumors), were recruited, with a parent: and teacher, from 3 university medical centers. The Behavioral Assessment System for Children questionnaires for chirdren/adolescents, parents and teachers were used. Parents reported a higher level of depression for the children/actolescents with cancer than did the teachers or the children/adolescents themselves. Parents reported a higher level of anxiety for the children/adolescents than did the teachers, High positive correlations were found among scores from parents and teachers and among scores from parents and children/adolescents for the anxiety and depression but not somatization subscales, Children/adolescents and teachers had high, positively correlated scores only for the depression subscale, High, positive correlations were found between somatization, anxiety and depression within each group of respondents. A significant percentage of agreement between all respondents on ratings for at-risk status was obtained only for the depression subscale, Age was the only variable found to have an influence on scores and only for the anxiety subscale. Int J. Cancer Suppl. 12:52-57, 1999. J 1999 Wiley-Liss, Inc.
SN 0020-7136
PY 1999
SU Suppl. 12
BP 52
EP 57
UT ISI:000084615500010
ER

PT J
AU MacBride, SK
Whyte, F
TI Attendance at cancer follow-up clinic: Does it increase anxiety or provide reassurance for men successfully treated for testicular cancer?
SO CANCER NURSING
AB This cross-sectional descriptive study examined the meaning of the cancer follow-up clinic for men who have been successfully treated for testicular cancer. The sample of 62 men were selected using a nonprobability quota sampling method before attendance at a routine testicular cancer follow-up clinic within the Directorate of Clinical Oncology, Western General Hospitals NHS Trust, Edinburgh, Scotland. Subjects were given four instruments to complete immediately before seeing the doctor in the clinic, and two instruments to complete on day 8 after the clinic appointment. Instruments included die State-Trait Anxiety Inventory (STAI), a demographic questionnaire, and two Likert scales adapted for use in the study: the Common Concerns about Testicular Cancer questionnaire and the Psychological Consequences of Screening questionnaire (PCQ). Results demonstrated that men attending the clinic exhibit low levels of anxiety at the paints measured, but gain a great deal of reassurance from the clinic visit. Results also demonstrated the areas of concern about testicular cancer and its management that influence anxiety in the follow-up clinic.
SN 0162-220X
PD DEC
PY 1999
VL 22
IS 6
BP 448
EP 455
UT ISI:000084000500007
ER

PT J
AU Patiraki, E
Gika, M
Pappa, D
Kiritsi, H
Haralambidou, E
Anagnostopoulos, F
TI Anxiety levels in family caregivers of cancer patients receiving chemotherapy
SO EUROPEAN JOURNAL OF CANCER
SN 0959-8049
PD SEP
PY 1999
VL 35
SU Suppl. 4
BP S38
EP S38
UT ISI:000083068300133
ER

PT J
AU Nordin, K
Berglund, G
Glimellus, B
Sjoden, PO
TI Predicting anxiety and depression among cancer patients
SO EUROPEAN JOURNAL OF CANCER
SN 0959-8049
PD SEP
PY 1999
VL 35
SU Suppl. 4
BP S276
EP S276
UT ISI:000083068301090
ER

PT J
AU Heim, ME
Kunert, S
Ozkan, I
TI Anxiety and depression in cancer patients - The HADS-questionnaire as screening instrument in cancer rehabilitation
SO EUROPEAN JOURNAL OF CANCER
SN 0959-8049
PD SEP
PY 1999
VL 35
SU Suppl. 4
BP S281
EP S281
UT ISI:000083068301111
ER

PT J
AU Lloyd-Williams, M
Friedman, T
Rudd, N
TI Should the depression sub scale of the Hospital anxiety and Depression scale be used as a screen for depression in patients with advanced metastatic cancer?
SO EUROPEAN JOURNAL OF CANCER
SN 0959-8049
PD SEP
PY 1999
VL 35
SU Suppl. 4
BP S365
EP S366
UT ISI:000083068301465
ER

PT J
AU Hyodo, I
Eguchi, K
Takigawa, N
Segawa, Y
Hosokawa, Y
Kamejima, K
Inoue, R
TI Psychological impact of informed consent in hospitalized cancer patients - A sequential study of anxiety and depression using the Hospital Anxiety and Depression scale
SO SUPPORTIVE CARE IN CANCER
AB Patients with cancer receive an explanation of their disease and the recommended treatment when they are asked to give informed consent (IC). In the course of this process patients suffer severe distress, including anxiety and depression, but physicians tend to underestimate it.;The goal of this study was to reveal the magnitude of such stress and any changes to this during the IC process by means of the Hospital Anxiety and Depression (HAD) scale, a self-assessment scale. Of 171 inpatients newly diagnosed with lung cancer, 119 were assessable for serial HAD scale scores on admission, immediately after the IC process, and at 1 and again at 2 weeks after the IC, Both anxiety and depression scores increased significantly immediately after IC, Female patients had significantly higher anxiety and depression scores than males at 1 week after the IC, The patients with poor performance status demonstrated high anxiety scores on admission and immediately after the ICI and substantial depression persisted longer in these patients. The prevalence of high scores of more than 11 (judged as adjustment disorder or more severe state) immediately after the IC was 50% for anxiety and 31% for depression. The prevalence decreased significantly within 1 or 2 weeks, but 41% and 14% of the patients still showed high anxiety and depression scores, respectively. Physicians should be aware of these facts and pay special attention to their patients' psychological distress in routine clinical practice.
SN 0941-4355
PD NOV
PY 1999
VL 7
IS 6
BP 396
EP 399
UT ISI:000083322700007
ER

PT J
AU Giarelli, E
TI Spiraling out of control: One case of pathologic anxiety as a response to a genetic risk of cancer
SO CANCER NURSING
AB The threat of cancer can result in an existential crisis characterized by feelings of uncertainty and fear. Anxiety, the most common response to the threat of cancer, may be expressed in ways as varied as individual personalities and circumstances. It is a normal response to the threat of cancer, but in some it may deteriorate to pathologic anxiety, and manifest somatic or avoidant patterns. members of families diagnosed with genetic mutations that predispose to cancer are unique in that they experience a complex chain of life events. People affected with genetic mutations that increase the risk for the development of cancer may be at greater risk of manifesting abnormal anxiety. Little research exists that can guide the health professional in meeting the needs of these individuals, which leads health practitioners to approach their needs on the basis of combined theoretical assumptions about the needs of people with cancer, people who have family members with cancel; and people with recurrent cancer: Some factors may be assessed by the health professional as an aid in identifying an individual at increased risk of developing a psychopathology. These factors include age and developmental level, existence of a previous psychologic disorder, and family integrity. Advanced practice nurses may effectively intervene in the care of these patients by (a) accurately assessing the risk for and extent of the anxiety reaction in individuals and family members; (b) developing management plans that include ongoing support, education, psychotherapy, and pharmacotherapeutics for the individual; and (c) support and psychotherapy for the family. In this article, the pathologic anxiety experienced by one adolescent girl diagnosed with a genetic mutation that caused multiple endocrine neoplasia 2a is addressed, along with the treatment of her avoidant anxiety disorder-trichotillomania.
SN 0162-220X
PD OCT
PY 1999
VL 22
IS 5
BP 327
EP 339
UT ISI:000082916300001
ER

PT J
AU Wellisch, DK
Hoffman, A
Goldman, S
Hammerstein, J
Klein, K
Bell, M
TI Depression and anxiety symptoms in women at high risk for breast cancer: Pilot study of a group intervention
SO AMERICAN JOURNAL OF PSYCHIATRY
AB Objective: The psycho-oncology literature to date contains only one outcome study based on a group model for high-risk relatives of breast cancer patients. The authors set out to study the effects of group intervention in high-risk relatives of breast cancer patients. Method: Thirty-three high-risk relatives of breast cancer patients participated in a six-session, 12-hour group intervention model that consisted of educational and psychosocial components. Results: There was a significant reduction of depression symptoms as reported on the Center for Epidemiologic Studies Depression Scale. Similarly, there was a significant reduction of anxiety symptoms as reported on the State-Trait Anxiety Inventory state scale. Conclusions: In this pilot study the investigators found the group intervention model effective at reducing symptoms of depression and reactive (not chronic) anxiety.
SN 0002-953X
PD OCT
PY 1999
VL 156
IS 10
BP 1644
EP 1645
UT ISI:000082896500028
ER

PT J
AU Sheard, T
Maguire, P
TI The effect of psychological interventions on anxiety and depression in cancer patients: results of two meta analyses
SO BRITISH JOURNAL OF CANCER
AB The findings of two meta-analyses of trials of psychological interventions in patients with cancer are presented: the first using anxiety and the second depression, as a main outcome measure. The majority of the trials were preventative, selecting subjects on the basis of a cancer diagnosis rather than on psychological criteria. For anxiety, 25 trials were identified and six were excluded because of missing data. The remaining 19 trials (including five unpublished) had a combined effect size of 0.42 standard deviations in favour of treatment against no-treatment controls (95% confidence interval (CI) 0.08-0.74, total sample size 1023). A most robust estimate is 9.36 which is based on a subset of trials which were randomized, scored well on a rating of study quality, had a sample size >40 and in which the effect of trials with very large-effects were cancelled out. For depression; 30 trials were identified, but ten were excluded because of missing data. The remaining 20 trials (including six unpublished) had a combined effect size of 0.36 standard deviations in favour of treatment against no-treatment controls (95% CI 0.06-0.66, sample size 1101). This estimate was robust for publication bias, but not study quality, and was inflated by three trials with very large effects. A more robust estimate of mean effect is the clinically weak to negligible value of 0.19. Group therapy is at least as effective as individual. Only four trials targeted interventions at those identified as-at risk of, or suffering significant psychological distress, these were associated with clinically powerful effects (trend) relative to unscreened subjects. The findings suggest that preventative psychological interventions in cancer patients may have a moderate clinical effect upon anxiety but not depression. There are indications that interventions targeted at those at risk of or suffering significant psychological distress have-strong clinical effects. Evidence an the effectiveness of such targeted interventions and of the feasibility and effects of group therapy in a European context is required.
SN 0007-0920
PD AUG
PY 1999
VL 80
IS 11
BP 1770
EP 1780
UT ISI:000081900300015
ER

PT J
AU Kramer, JA
TI Use of the Hospital Anxiety and Depression Scale (HADS) in the assessment of depression in patients with inoperable lung cancer
SO PALLIATIVE MEDICINE
SN 0269-2163
PD JUL
PY 1999
VL 13
IS 4
BP 353
EP 354
UT ISI:000081926000010
ER

PT J
AU Cain, BS
Meldrum, DR
Dinarello, CA
Meng, XZ
Joo, KS
Banerjee, A
Harken, AH
TI Tumor necrosis factor-alpha and interleukin-1 beta synergistically depress human myocardial function
SO CRITICAL CARE MEDICINE
AB Objective: Proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin (II)-1 beta have been implicated in the pathogenesis of myocardial dysfunction in ischemia-reperfusion injury, sepsis, chronic heart failure, viral myocarditis, and cardiac allograft rejection. Although circulating TNF-alpha and IL-1 beta are both often elevated in septic shock, it remains unknown whether TNF-alpha or IL-1 beta are the factors induced during sepsis that directly depress human myocardial function, and if so, whether the combination synergistically depresses myocardial function. Furthermore, the mechanism(s) by which these cytokines induce human myocardial depression remain unknown. We hypothesized the following: a) TNF-alpha and IL-1 beta directly depress human myocardial function; b) together, TNF-alpha and IL-1 beta act synergistically to depress human myocardial function; and c) inhibition of ceramidase or nitric oxide synthase attenuates myocardial depression induced by TNF-alpha or IL-1 beta by limiting proximal cytokine signaling or production of myocardial nitric oxide (NO).
Design:Prospective, randomized, controlled study.
Setting: Experimental laboratory in a university hospital.
Subjects: Freshly obtained human myocardial trabeculae.
Interventions: Human atrial trabeculae were obtained at the time of cardiac surgery, suspended in organ baths, and field simulated at 1 Hz, and the developed force was recorded. After a 90-min equilibration, TNF-alpha (1.25, 12.5, 125, or 250 pg/mL for 20 mins), IL-1 beta (6.25, 12.5, 50, or 200 pg/mL for 20 mins), or TNF-alpha (1.25 pg/mL) plus IL-1 beta (6.25 pg/mL) were added to the bath, and function was measured for the subsequent 100 mins after the 20-min exposure. To assess the roles of the sphingomyelin and NO pathways in TNF-alpha and IL-1 beta cross-signaling, the ceramidase inhibitor N-oleoyl ethanolamine (1 mu M) or the NO synthase inhibitor NG-monomethyl-L-arginine (10 mu M) was added before TNF-alpha (125 pg/mL) or IL-beta (50 pg/mL).
Measurements and Main Results:TNF-alpha and IL-1 beta each depressed human myocardial function in a dose-dependent fashion (maximally depressing to 16.2 + 1.9% baseline developed force for TNF-alpha and 25.7 + 6.3% baseline developed force for IL-1 beta), affecting systolic relatively more than diastolic performance teach p < .05). However, when combined, TNF-alpha and IL-1 beta at concentrations that did not individually result in depression (p >.05 vs, control) resulted in contractile depression (p < .05 vs. control). Inhibition of myocardial sphingosine or NO release abolished the myocardial depressive effects of either TNF-alpha or IL-1 beta.
Conclusions:TNF-alpha and IL-1 beta separately and synergistically depress human myocardial function. Sphingosine likely participates in the TNF-alpha and IL-1 beta signal leading to human myocardial functional depression. Therapeutic strategies to reduce production or signaling of either TNF-alpha or IL-1 beta may limit myocardial dysfunction in sepsis.
SN 0090-3493
PD JUL
PY 1999
VL 27
IS 7
BP 1309
EP 1318
UT ISI:000081906300013
ER

PT J
AU Ronson, A
Razavi, D
TI Affective and anxiety disorders in patients with cancer - Optimal management
SO CNS DRUGS
AB Cancer, at all sites and stages (from early diagnosis to terminal phase), has psychological effects in a significant number of patients. Diagnosis of depression and anxiety in this patient population can be difficult and must involve awareness of the symptoms and signs resulting from the cancer itself and antineoplastic therapies, and the differential diagnosis of 'function' and 'organic' mental disorders. When prescribing psychotropic medications to patients with cancer, particular attention should be paid to drug interactions (e.g. the potential influence of psychoactive drugs on the metabolism of chemotherapeutic agents). Despite provocative reports, it has to be acknowledged that to date, there is no evidence to substantiate the claim of a negative impact of antidepressants on cancer initiation or prognosis. Although studies assessing the comparative effectiveness of psychopharmacological agents are difficult to perform in patients with cancer, the efficacy and tolerability of several antidepressants and anxiolytics have been shown and a mixed approach, combining drug treatments and various forms of psychotherapy, is now widely encouraged. However, a lot of research remains to be conducted in order to better understand the specific relationships between cancer and psychopathology, to identify risk factors and develop preventative strategies and to define a general model of treatment for psychiatric disturbances in patients with cancer.
SN 1172-7047
PD AUG
PY 1999
VL 12
IS 2
BP 119
EP 133
UT ISI:000081949000005
ER

PT J
AU Groenvold, M
Fayers, PM
Sprangers, MAG
Bjorner, JB
Klee, MC
Aaronson, NK
Bech, P
Mouridsen, HT
TI Anxiety and depression in breast cancer patients at low risk of recurrence compared with the general population: A valid comparison?
SO JOURNAL OF CLINICAL EPIDEMIOLOGY
AB Breast cancer and its treatment have been associated with psychological morbidity. In this study our aim was to quantify the excess anxiety and depression resulting from breast cancer. We compared 538 newly diagnosed breast cancer patients at low risk of recurrence (87.0% responded) to 872 women randomly selected from the Danish general population (69.7% responded) using the Hospital Anxiety and Depression Scale (HADS). Contrary to expectations, the proportions classified as "cases" of anxiety and depression were not significantly different in the two groups. The breast cancer patients' mean HADS scores were significantly lower than those in the general population sample (anxiety, P = 0.021; depression, P < 0.001), indicating less anxiety and depression. However, we question the validity of this comparison. The HADS may not be suitable for use in the general population and there may be methodological problems in comparisons of groups whose life situations are very different. (C) 1999 Elsevier Science Inc.
SN 0895-4356
PD JUN
PY 1999
VL 52
IS 6
BP 523
EP 530
UT ISI:000081015300006
ER

PT J
AU Lawvere, S
Moscato, B
Donahue, R
Mettlin, C
TI The effect of massage therapy on self-reported anxiety, depressive mood and pain in ovarian cancer patients: Initial findings.
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
SN 0002-9262
PD JUN 1
PY 1999
VL 149
IS 11
SU Suppl. S
BP S30
EP S30
UT ISI:000080526500119
ER

PT J
AU Costantini, M
Musso, M
Viterbori, P
Bonci, F
Del Mastro, L
Garrone, O
Venturini, M
Morasso, G
TI Detecting psychological distress in cancer patients: validity of the Italian version of the Hospital Anxiety and Depression Scale
SO SUPPORTIVE CARE IN CANCER
AB The psychometric properties of the Italian version of the Hospital Anxiety and Depression Scale and its utility as a screening instrument for anxiety and depression in a non-psychiatric setting were evaluated. The questionnaire was administered twice to 197 breast cancer patients randomised in a phase III adjuvant clinical trial: before the start of chemotherapy and at the first followup visit. The presence of psychiatric disorders was evaluated at the followup visit using the Structured Clinical Interview for DSM-III-R in 132 patients. Factor analyses identified two strictly correlated factors. Crohnbach's alpha for the anxiety and depression scales ranged between 0.80 and 0.85. At follow-up, 50 patients (38%) were assigned a current DSM-III-R diagnosis, in most cases adjustment disorders (24%) or major depressive disorder (10%). Receiver operating characteristics (ROC) analysis was used to test the discriminant validity for both anxiety and depressive disorders. The comparison of the areas under the curve (AUC) between the two scales did not show any difference in identifying either anxiety (P=0.855) or depressive disorders (P=0.357). The 14-item total scale showed a high internal consistency (alpha=0.89 and 0.88) and a high discriminating power for all the psychiatric disorders (AUC=0.89; 95% CI=0.83-0.94). The cut-off point that maximised sensitivity (84%) and specificity (79%) was 10. These results suggest that the total score is a valid measure of emotional distress, so that the Italian version of HADS can be used as a screening questionnaire for psychiatric disorders. The use of the two subscales as a 'case identifier' or as an outcome measure should be considered with caution.
SN 0941-4355
PD MAY
PY 1999
VL 7
IS 3
BP 121
EP 127
UT ISI:000079908300004
ER

PT J
AU Holden, RJ
Pakula, IS
TI Tumor necrosis factor-alpha: is there a continuum of liability between stress, anxiety states and anorexia nervosa?
SO MEDICAL HYPOTHESES
AB Since the time of Freud, psychiatry has embraced the proposition that physiological and/or psychological stress precipitates various psychiatric disorders. To this effect, we propose that a continuum of liability obtains between stress, anxiety states and anorexia nervosa - a continuum which is grounded on a cytokine profile common to each of these conditions. For example, the biological response to stress, anxiety states and anorexia nervosa includes the elevation of interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha), and downregulation of interferon-gamma (IFN-gamma). Sustained elevation of IL-1 beta and TNF-alpha dysregulates both somatostatin and insulin secretion, the tatter of which influences regional cerebral blood flow (rCBF) and brain energy metabolism. In addition, IL-1 beta and TNF-alpha influence the expression of certain crucial neuropeptides, which are known to be associated with anxiety states and anorexia nervosa. These neuropeptides include: beta-endorphin, cholecystokinin (CCK), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP). beta-endorphin effects glucose metabolism in the limbic system, CCK increases the release of beta-endorphin from the anterior pituitary, NPY is a powerful anxiolytic that regulates beta-endorphin and insulin, while VIP indirectly regulates the expression of TNF-alpha through the inhibition of interleukin-4 (IL-4).
SN 0306-9877
PD FEB
PY 1999
VL 52
IS 2
BP 155
EP 162
UT ISI:000079688900010
ER

PT J
AU Brain, K
Norman, P
Gray, J
Mansel, R
TI Anxiety and adherence to breast self-examination in women with a family history of breast cancer
SO PSYCHOSOMATIC MEDICINE
AB Objective: Previous research has indicated low rates of adherence to monthly breast self-examination (BSE) in women with a family history of breast cancer, and anxiety has been identified as a major factor that may interfere with regular self-examination. However, the direction of the relationship between anxiety and BSE frequency remains unclear, with some studies indicating that high anxiety promotes adherence and others indicating that it leads to avoidance. The aim of the present study was to clarify the relationship between anxiety and adherence to breast self-examination by comparing the impact of general anxiety with that of cancer-specific anxiety on BSE frequency. Methods: A sample of at-risk women (N = 833) completed a questionnaire regarding BSE frequency, general anxiety, breast cancer worries, perceived risk of breast cancer, and family history of breast cancer. Women who self-examined infrequently (N = 211), appropriately (N = 462), or excessively (N = 156) were compared on these variables. Results: Statistical analyses indicated that general anxiety differentiated only between excessive self-examiners and less frequent self-examiners, with excessive self-examiners reporting significantly higher general anxiety. Breast cancer worries differentiated between all three groups in a linear fashion, with increasing cancer worries associated with higher levels of BSE. Conclusions: In some at-risk women, high cancer anxiety may lead to high general anxiety and precipitate hypervigilant breast self-examination rather than avoidance. These findings are discussed in relation to psychoeducational interventions and genetic counseling services for women with a family history of breast cancer.
SN 0033-3174
PD MAR-APR
PY 1999
VL 61
IS 2
BP 181
EP 187
UT ISI:000079301000010
ER

PT J
AU Hall, A
A'Hern, R
Fallowfield, L
TI Are we using appropriate self-report questionnaires for detecting anxiety and depression in women with early breast cancer?
SO EUROPEAN JOURNAL OF CANCER
AB The aim of this prospective study was to identify the psychiatric morbidity associated with the diagnosis and treatment of early breast cancer. At each of five time points, 269 women were interviewed using a shortened version of the Present State Examination (PSE) and 266 completed self-assessment questionnaires, the Hospital and Anxiety Depression Scale (HADS) and the Rotterdam Symptom Checklist (RSCL). This paper compares the ability of the questionnaires to detect psychiatric morbidity with that of the PSE. The majority of women who experienced anxiety and/or depression did so within 3 months of their initial surgery. The clinical interview identified anxiety disorder in 132 of 266 women (49.6%) and depressive illness in 99/266 (37.2%) during the first 3 months. Using the recommended threshold of greater than or equal to 11 for caseness, the sensitivities for both tests were very low at 24.2% (HADS anxiety) and 14.1% (HADS depression) and 30.6% (RSCL psychological distress scale). Lowering the threshold value to greater than or equal to 7 on the HADS improved the sensitivity to 72% for the anxiety subscale, but it remained low at 37.4% for the depression subscale. A threshold of greater than or equal to 7 for the RSCL scale raised sensitivity to 66.7%. Lowering the threshold values raised the sensitivity of both the instruments but decreased their specificity: the lower the threshold, the greater the number of women who were identified as false positives which would increase the work load for clinic staff if used as a screening tool. Given that the HADS was inadequate in discriminating for depressive illness, it was not surprising that its use as a unitary scale with a threshold value as low as 12 resulted in a sensitivity of only 42.7%. In the light of these findings, we question the use of both the HADS and the RSCL as suitable research or screening instruments for detection of psychological morbidity in early breast cancer. (C) 1999 Elsevier Science Ltd. All rights reserved.
SN 0959-8049
PD JAN
PY 1999
VL 35
IS 1
BP 79
EP 85
UT ISI:000078642500017
ER

PT J
AU Payne, DK
Hoffman, RG
Theodoulou, M
Dosik, M
Massie, MJ
TI Screening for anxiety and depression in women with breast cancer - Psychiatry and medical oncology gear up for managed care
SO PSYCHOSOMATICS
AB In this study 275 women with breast cancer attending ambulatory breast cancer clinics in two sites were evaluated for psychological distress by rising three self-report instruments: a visual analogue scale for psychological distress, the Hospital Anxiety and Depression Scale, and the Brief Symptom Inventory. Results suggest that significant psychological distress exists in ambulatory women with breast cancer; all three instruments effectively measured that level of distress. Implications for the use of these instruments in educating oncological staff members, documentations of psychiatric services are discussed.
SN 0033-3182
PD JAN-FEB
PY 1999
VL 40
IS 1
BP 64
EP 69
UT ISI:000078232900009
ER

PT J
AU Nordin, K
Glimelius, B
TI Predicting delayed anxiety and depression in patients with gastrointestinal cancer
SO BRITISH JOURNAL OF CANCER
AB The aim of this study was to examine the possibility of predicting anxiety and depression 6 months after a cancer diagnosis on the basis of measures of anxiety, depression, coping and subjective distress associated with the diagnosis and to explore the possibility of identifying individual patients with high levels of delayed anxiety and depression associated with the diagnosis. A consecutive series of 159 patients with gastrointestinal cancer were interviewed in connection with the diagnosis, 3 months (non-cured patients only) and 6 months later. The interviews utilized structured questionnaires assessing anxiety and depression [Hospital Anxiety and Depression (HAD) scale], coping [Mental Adjustment to cancer (MAC) scale] and subjective distress [Impact of Event (IES) scale]. Patient anxiety and depression close to the diagnosis were found to explain approximately 35% of the variance in anxiety and depression that was found 6 months later. The addition of coping and subjective distress measures did little to improve that prediction. A model using (standardized) cut-off scores of moderate to high anxiety, depression (HAD) and intrusive thoughts (IES subscale) close to the diagnosis to identify patients at risk for delayed anxiety and depression achieved a sensitivity of 75% and a specificity of 98%. Levels of anxiety and depression at diagnosis predicted a similar status 6 months later. The results also indicated that the HAD scale in combination with the IES intrusion subscale may be used as a tool for detecting patients at risk of delayed anxiety and depression.
SN 0007-0920
PD FEB
PY 1999
VL 79
IS 3-4
BP 525
EP 529
UT ISI:000078165200023
ER

PT J
AU Boermeester, F
Berard, RMF
TI Factor structure of the Hospital Anxiety and Depression Scale in cancer patients
SO SOUTH AFRICAN MEDICAL JOURNAL
AB Objectives. The Hospital Anxiety and Depression Scale (HADS) has been shown to be an effective screening tool for oncology settings. Its increasing popularity in various parts of the world highlights the need for continuous psychometric evaluation, in particular with regard to the cross-cultural validity of the instrument, and to debates regarding the appropriate use of the scale.
Method. The HADS was completed by 456 cancer patients attending an oncology outpatient clinic at Groote Schuur Hospital, a large tertiary care institution in Cape Town, South Africa. Internal reliability coefficients were calculated and the factor structure of the HADS was assessed using a principal component analysis.
Results. The results are consistent with previous data reported from the UK, and therefore support the bidimensionality of the HADS in cancer patients. The depression subscale appears to measure a relatively homogeneous construct representing the symptom of anhedonia.
Conclusion. The HADS can be a used in under-resourced and under-staffed oncology settings and still emerge as a robust screening instrument.
SN 0038-2469
PD NOV
PY 1998
VL 88
IS 11
SU Suppl. 2
BP 1495
EP +
UT ISI:000077601100005
ER

PT J
AU Thomas, R
Brown, C
Dalton, L
Welton, S
Stockton, D
TI Anxiety and depression - Effect on patients preferences for information following a diagnosis of cancer
SO ANNALS OF ONCOLOGY
SN 0923-7534
PY 1998
VL 9
SU Suppl. 4
BP 141
EP 141
UT ISI:000076947100667
ER

PT J
AU Aziz, Z
Qazi, S
Akram, S
Latif, T
Rehman, A
TI Prevalence of anxiety and depression in cancer patients receiving chemotherapy
SO ANNALS OF ONCOLOGY
SN 0923-7534
PY 1998
VL 9
SU Suppl. 4
BP 143
EP 143
UT ISI:000076947100678
ER

PT J
AU Ozet, A
Isikhan, V
Arpaci, F
Ozturk, B
Komurcu, S
TI Interpersonal sensitivity, depression and anxiety positions of patients with breast cancer
SO ANNALS OF ONCOLOGY
SN 0923-7534
PY 1998
VL 9
SU Suppl. 4
BP 147
EP 147
UT ISI:000076947100693
ER

PT J
AU Julian-Reynier, C
Eisinger, F
Chabal, F
Aurran, Y
Bignon, YJ
Nogues, C
Machelard, M
Maugard, C
Vennin, P
Sobol, H
TI Time elapsing from cancer diagnosis and anxiety in women attending cancer genetic clinics
SO ONCOLOGY REPORTS
AB The aim of this study was to investigate the effects of cancer genetic consultations on feelings of anxiety in women with breast/ovarian cancer. Among the 138 women attending six French clinics during a one-year period, 115 (83.3%) answered pre-and post-consultation questionnaires. The state anxiety score (Spielberger's STAI) was lower (paired t-test, p<0.001) after the consultation (34.7+/-9.4) than before (38.8+/-10.5). The time elapsing since cancer diagnosis (r=-0.28, p=0.007) was the main predictor of the decrease in anxiety. The patients consulting earlier after their cancer was diagnosed were more anxious before the consultation than those consulting later: whereas their anxiety states after the consultation were similar. The consultation effectively decreased the anxiety observed and the anxiety felt by cancer patients before the consultation may constitute an anticipatory stress response that should be investigated.
SN 1021-335X
PD JUL-AUG
PY 1998
VL 5
IS 4
BP 885
EP 888
UT ISI:000074173100020
ER

PT J
AU Hoffman, R
Payne, D
Theodoulou, M
Massie, MJ
TI Screening for anxiety & depression in women with breast cancer
SO PSYCHOSOMATICS
SN 0033-3182
PD MAR-APR
PY 1998
VL 39
IS 2
BP 225
EP 229
UT ISI:000073267900086
ER

PT J
AU Montazeri, A
Milroy, R
Hole, D
McEwen, J
Gillis, CR
TI Anxiety and depression in patients with lung cancer before and after diagnosis: findings from a population in Glasgow, Scotland
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
SN 0143-005X
PD MAR
PY 1998
VL 52
IS 3
BP 203
EP 204
UT ISI:000072362700014
ER

PT J
AU [Anon]
TI Beat breast cancer anxiety
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
SN 0098-7484
PD FEB 25
PY 1998
VL 279
IS 8
BP 574
EP 574
UT ISI:000072041900008
ER

PT J
AU Brewin, CR
Watson, M
McCarthy, S
Hyman, P
Dayson, D
TI Memory processes and the course of anxiety and depression in cancer patients
SO PSYCHOLOGICAL MEDICINE
AB Background. Intrusive memories of stressful events, many involving illness and death, are found in a minority of depressed cancer patients, and may predict the course of anxiety and depression.
Method. Matched samples of mild to moderately depressed and non-depressed cancer patients were followed up after 6 months. Anxiety and depression at follow-up were related to measures of intrusive memories of stressful life events and autobiographical memory functioning that had been assessed at baseline.
Results. Levels of anxiety and depression remained fairly constant over time in the two groups, and the depressed group continued to experience high levels of intrusive memories. The presence of intrusive memories at baseline, and the extent to which these memories were consciously avoided, predicted greater anxiety at follow-up, even after controlling for initial severity of physical and psychiatric symptoms. None of the measures of memory functioning predicted levels of depression at follow-up.
Conclusions. Intrusive memories appear to be a marker of more prolonged psychopathology in cancer patients and may respond to direct therapeutic intervention.
SN 0033-2917
PD JAN
PY 1998
VL 28
IS 1
BP 219
EP 224
UT ISI:000071746500022
ER

PT J
AU Hughes-Benzie, R
Perras, H
Graham, I
Coyle, D
TI Characteristics of a Canadian population at risk for hereditary colorectal cancer: Demographics, risk perception, anxiety and depression levels.
SO AMERICAN JOURNAL OF HUMAN GENETICS
SN 0002-9297
PD OCT
PY 1997
VL 61
IS 4
SU Suppl. S
BP A189
EP A189
UT ISI:000071446001092
ER

PT J
AU Wilkinson, S
TI Aromatherapy as an anxiety management programme for patients with cancer
SO EUROPEAN JOURNAL OF CANCER
SN 0959-8049
PD SEP
PY 1997
VL 33
SU Suppl. 8
BP 279
EP 279
UT ISI:A1997XX83000278
ER

PT J
AU Aass, N
Fossa, SD
Dahl, AA
Moe, TJ
TI Prevalence of anxiety and depression in cancer patients seen at the Norwegian Radium Hospital
SO EUROPEAN JOURNAL OF CANCER
AB The aim of this study was to investigate the prevalence of anxiety and depression in cancer patients seen at the Norwegian Radium Hospital, using the Hospital Anxiety and Depression Scale (HADS), the EORTC QLQ-C33 and an ad hoc designed questionnaire. In addition, information about the patients' malignant disease and treatment was obtained. The prevalence of anxiety and depression among 716 evaluable patients was 13% and 9% respectively, as assessed with HADS. In hospitalised patients, the risk of psychiatric distress was approximately twice that of patients in the outpatient clinic. Female patients reported significantly more anxiety than men. Patients <30 or >70 years old expressed less anxiety than all other patients. Age or gender had no influence on the occurrence of depression. Impaired ability to continue professional work and/or daily life activities, impaired social life and previous psychiatric problems were significantly correlated with anxiety and depression as were impaired physical function, fatigue and pain. The prevalence of depression, but not anxiety, increased in the presence of distant metastases, with less than a month since diagnosis, and with relapse or progression. In the logistic regression analysis, a history of previous psychiatric problems and impaired social life were correlated with both anxiety and depression. Female gender, impaired physical activity and impaired social role function were additional predictive parameters for anxiety, whereas fatigue predicted depression. Careful attention should be paid to cancer patients displaying these problems in order to diagnose and treat depression and anxiety disorders. (C) 1997 Elsevier Science Ltd.
SN 0959-8049
PD SEP
PY 1997
VL 33
IS 10
BP 1597
EP 1604
UT ISI:A1997YD33400017
ER

PT J
AU Hodgson, C
Higginson, I
McDonnell, M
Butters, E
TI Family anxiety in advanced cancer: a multicentre prospective study in Ireland
SO BRITISH JOURNAL OF CANCER
AB Six home care services in Southern Ireland collected data on a total of 757 patients over a 6-month period. Patient and family wellbeing were measured using the staff-rated Support Team Assessment Schedule and Karnofsky Index. Five hundred and eight patients died while in care, 75% of whom died at home. At referral, 32% of families were rated as having severe or overwhelming anxiety. During the last week of care, anxiety remained severe for 26% of family members. Patient and family well-being were inter-related, and there were significant interactions between family anxiety and patient physical and psychological symptoms, and communication. Discriminant analysis produced two predictive models. In model 1,family anxiety at referral strongly predicts family anxiety in the last week of life. In model 2, family anxiety at referral is excluded from the analysis, and the significant predictor factors at referral for family anxiety in the last 4 weeks of life are patient symptom control, sex of patient, diagnosis and patient age.
SN 0007-0920
PD NOV
PY 1997
VL 76
IS 9
BP 1211
EP 1214
UT ISI:A1997YD13400016
ER

PT J
AU Allen, R
Newman, SP
Souhami, RL
TI Anxiety and depression in adolescent cancer: Findings in patients and parents at the time of diagnosis
SO EUROPEAN JOURNAL OF CANCER
AB Adolescent cancer is uncommon and presents an exceptional stress for the young patient and their parents. The emotional needs of adolescents with cancer are a major factor in the recommendation for the establishment of adolescent cancer units in major cancer centres in the U.K. However, there have been no prospective, longitudinal studies assessing the psychological impact of a diagnosis of cancer on the adolescent patient and their family. In 1994 we began a longitudinal study of the emotional impact of the diagnosis of cancer in patients and their families presenting to an adolescent cancer unit and of the coping strategies they employ. This first report presents the results of the study at the time of diagnosis in 42 adolescents, 34 mothers and 27 fathers. The Beck Depression Inventory (BDI) was used to assess depression and anxiety levels were measured using Spielberger's State Trait Anxiety Inventory (STAI). Adolescents and their parents completed the questionnaires on first admission to the adolescent cancer unit. The median time since cancer diagnosis was approximately 3 weeks. To provide normative data for the U.K, adolescent population, control values were obtained from 173 pupils of the same age and background. The results showed that, contrary to expectation, adolescents with cancer were no more anxious or depressed than the control adolescent population. Nevertheless, a substantial minority of patients and controls had elevated anxiety or depression scores. Girls were significantly more anxious (P=0.011) and depressed (P<0.0001) than boys. Mothers were the most anxious family members and were significantly more anxious than fathers (P=0.038). Parental anxiety scores, especially mothers, were much higher than reported norms. There was no significant difference between mothers' and fathers' depression scores. Although at the time of diagnosis adolescent cancer patients are not more anxious or depressed than their healthy peers, many adolescents without cancer are anxious or depressed. Staff on adolescent cancer units should therefore be aware of the frequency of emotional disturbance in this population. Mothers are the most anxious family members. Although the findings are relatively reassuring at the time of diagnosis, follow-up data from this cohort will show whether anxiety and depression change with treatment involving intensive chemotherapy, surgery and radiotherapy and will indicate the coping strategies which patients and their families adopt in dealing with both the disease and its treatment. (C) 1997 Published by Elsevier Science Ltd.
SN 0959-8049
PD JUL
PY 1997
VL 33
IS 8
BP 1250
EP 1255
UT ISI:A1997XR38300026
ER

PT J
AU Payne, D
Theodoulou, M
Darby, A
DeAngelis, C
Massie, MJ
TI Screening for anxiety and depression in breast cancer patients
SO PSYCHOSOMATICS
SN 0033-3182
PD MAR-APR
PY 1997
VL 38
IS 2
BP 213
EP 214
UT ISI:A1997WL68300103
ER

PT J
AU Nakada, S
Nagao, K
Takiguchi, Y
Tatsumi, K
Kuriyama, T
TI Quality of life and anxiety before and after lung cancer chemotherapy: Relationship to patient's personality
SO INTERNAL MEDICINE
AB The purpose of the study was to assess the quality of life (QOL) and anxiety in 50 inpatients with primary lung cancer and examine the influence of their personalities on the QOL assessment, We used a psychological personality test to evaluate the patient's personality, then followed the course of QOL and anxiety before and after chemotherapy. To measure QOL, we used Holmes's QOL checklist, and the State-Trait Anxiety Inventory was adopted to estimate the patient's anxiety, Eighty courses of chemotherapy were administered, and QOL evaluations were performed 235 times, By using factor analysis, the somatic, social and psychological factors were extracted which confirmed the reliability and validity of the QOL checklist, The psychological QOL score showed a correlation with A (Adult) and AC (Adapted Child) of the five ego states in the Egogram. Therefore, it is important to survey the patients' personalities in order to grasp their QOL accurately.
SN 0918-2918
PD AUG
PY 1996
VL 35
IS 8
BP 611
EP 616
UT ISI:A1996VL38200007
ER

PT J
AU Razavi, D
Allilaire, JF
Smith, M
Salimpour, A
Verra, M
Desclaux, B
Saltel, P
Piollet, I
GauvainPiquard, A
Trichard, C
Cordier, B
Fresco, R
Guillibert, E
Sechter, D
Orth, JP
Bouhassira, M
Mesters, P
Blin, P
TI The effect of fluoxetine on anxiety and depression symptoms in cancer patients
SO ACTA PSYCHIATRICA SCANDINAVICA
AB Little has been done to study the effectiveness of antidepressants in controlling anxiety/depression in a population of cancer patients. A double-blind placebo-controlled study was therefore designed to assess the effectiveness of 20 mg fluoxetine, Of 115 cancer patients who fulfilled entry criteria for levels of distress, 45 patients were randomized to a fluoxetine treatment group (FA) and 46 patients to a placebo group (PA) after a 1-week placebo period designed to exclude placebo responders. The Montgomery and Asberg Depression Scale (MADRS), the Hamilton Anxiety Scale (HAS), the Hospital Anxiety and Depression Scale (HADS), the Revised Symptom Checklist (SCL90-R) and the Spitzer Quality of Life Index (SQOLI) were used to assess the efficacy of fluoxetine. The response rate, defined by a HADS score lower than 8 after 5 weeks of treatment, was not significantly higher in the FA group (11%) compared to the PA group (7%). Compared to the PA group, patients in the FA group showed a significantly greater decrease in SCL90-R mean total score after 5 weeks, but not a greater decrease in HADS mean score. No difference between the two groups was found in observer-reported assessments (MADRS, HAS and SQOLI). Significantly more drop-outs were observed in the FA group (n=15) than in the PA group (n=7), although the frequencies of side-effects were not significantly different.
SN 0001-690X
PD SEP
PY 1996
VL 94
IS 3
BP 205
EP 210
UT ISI:A1996VJ34200012
ER

PT J
AU Nordin, K
Glimelius, B
Pahlman, L
Sjoden, PO
TI Anxiety, depression and worry in gastrointestinal cancer patients attending medical follow-up control visits
SO ACTA ONCOLOGICA
AB Anxiety, depression and worry were assessed in 141 consecutive gastrointestinal cancer patients scheduled for follow-up control visits, Participants completed two questionnaires, one including the Hospital Anxiety and Depression Scale (HAD) in conjunction with the visit and one completed after, The overall levels of anxiety before, during and after the visit were low, There were no differences between those who were considered cured and those who were not. Anxiety levels after the visit were higher for those patients for whom less than one year had passed since diagnosis. Mean HAD scores for anxiety and depression were 4.2 and 4.3 respectively, Women reported a higher degree of anxiety than men. Using a score of 8 or more for 'borderline-possible cases', 15% fell into these categories on the anxiety scale and 12% on the depression scale, About 30% of the patients worried about seeing a new physician and 25% about what the examination or tests would show, It is concluded that regular, scheduled control visits pose a significant threat to the psychological well-being of only a minority of gastrointestinal cancer patients.
SN 0284-186X
PY 1996
VL 35
IS 4
BP 411
EP 416
UT ISI:A1996UX51000005
ER

PT J
AU Thirlaway, K
Fallowfield, L
Hunnerley, H
Powles, T
TI Anxiety in women 'at risk' of developing breast cancer
SO BRITISH JOURNAL OF CANCER
AB Do family history clinics offering counselling, surveillance and preventative programmes alleviate or exacerbate anxiety in women at a high risk of developing breast cancer? In this study risk perceptions and anxiety of 99 'at risk' women participating in the Tamoxifen Prevention Trial were compared with those of 87 'at risk' women not attending any specialist clinic who were recruited from the National Breast Screening Programme (NBSP). Most anxiety was found in NBSP women with a family history. Women attending the family history clinic and participating in the trial had anxiety scores comparable with 86 women recruited from the NBSP who did not have a family history. We conclude that such specialist clinics do not see a selected group of the most anxious 'at risk' women nor does participation in tamoxifen prevention programmes appear to increase anxiety.
SN 0007-0920
PD JUN
PY 1996
VL 73
IS 11
BP 1422
EP 1424
UT ISI:A1996UN61600019
ER

PT J
AU Weist, MD
Finney, JW
TI Training in early cancer detection and anxiety in adolescent males: A preliminary report
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
AB Because of concerns about increasing anxiety in a population that is at relatively low risk for developing cancer, some investigators have recommended that training in testicular self-examination (TSE) not be provided to adolescent males. However, empirical findings documenting a link between training in cancer detection and increased anxiety in adolescent males are lacking. In this preliminary study, we assessed whether training in TSE was actually associated with elevated state anxiety in two samples of adolescent males (29 ninth graders and 30 college underclassmen). For both groups, anxiety scores were well within normal limits at postassessment, indicating that a purported cost of the procedure may in fact not exist.
SN 0196-206X
PD APR
PY 1996
VL 17
IS 2
BP 98
EP 99
UT ISI:A1996UF57500006
ER

PT J
AU Last, BF
vanVeldhuizen, AMH
TI Information about diagnosis and prognosis related to anxiety and depression in children with cancer aged 8-16 years
SO EUROPEAN JOURNAL OF CANCER
AB The aim of this study was to test the hypothesis that being openly informed about the diagnosis and prognosis benefits the emotional well-being of children with cancer. A stratified sample of 56 children with cancer aged 8-16 years and their parents participated. The parents were interviewed about the information they had given to their child. Self-report questionnaires were administered to the children measuring anxiety and depression. Children who received open information about their diagnosis and prognosis at the initial stage of the disease showed significantly less anxiety and depression. Our findings suggest that parents should be advised to inform their child with cancer openly and soon after the initial diagnosis. Physicians should offer help to the parents in dealing with the difficult task of confronting the child with the diagnosis, prognosis and treatment.
SN 0959-8049
PD FEB
PY 1996
VL 32A
IS 2
BP 290
EP 294
UT ISI:A1996UA83200022
ER

PT J
AU Drossaert, CCH
Boer, H
Seydel, ER
TI Perceived risk, anxiety, mammogram uptake, and breast self-examination of women with a family history of breast cancer: The role of knowing to be at increased risk
SO CANCER DETECTION AND PREVENTION
AB Since women with a first-degree relative with breast cancer are at increased risk for breast cancer, it is of special importance that they adhere to early detection programs. In this study, women with (389) and without (3295) a family history of breast cancer were compared with respect to risk perception, breast cancer anxiety, and early detection behavior. Special attention was paid to the role of knowing that family history is a breast cancer risk factor. It was found that 46% of ''family history positives'' did not know that their risk was increased by their family history. Still, family history positives had increased risk perception; our results suggest that this was partly caused by their knowing they belonged to a risk group and partly by their having experienced the disease at close range. Although family history positives had higher risk perceptions, no differences in early detection behavior were found. This could not be attributed to high anxiety levels. Implications for health education are discussed.
SN 0361-090X
PY 1996
VL 20
IS 1
BP 76
EP 85
UT ISI:A1996TY26200010
ER

PT J
AU Kash, KM
Holland, JC
Jacobsen, PB
Osborne, MP
Miller, DG
TI Measuring breast cancer anxiety
SO PSYCHOSOMATICS
SN 0033-3182
PD MAR-APR
PY 1996
VL 37
IS 2
BP 200
EP 201
UT ISI:A1996TX04500067
ER

PT J
AU Lampic, C
vonEssen, L
Larsson, G
Pettersson, VW
Sjoden, P
TI Perceptions of the importance of caring behaviours and patient anxiety and depression levels in cancer patient-staff dyads
SO EUROPEAN JOURNAL OF CANCER
SN 0959-8049
PD NOV
PY 1995
VL 31A
SU Suppl. 5
BP 1441
EP 1441
UT ISI:A1995TH91901436
ER

PT J
AU JULIANREYNIER, C
CHABAL, F
SOBOL, H
AURRAN, Y
NOGUES, C
VENNIN, P
BIGNON, YJ
ROUMAGNAC, M
MAUGARDLOUBOUTIN, C
VERSINI, S
SERIN, D
MICHEL, JP
EISINGER, F
TI RISK PERCEPTION, ANXIETY AND ATTITUDES TOWARDS PREDICTIVE TESTING ALTER CANCER GENETIC CONSULTATIONS
SO AMERICAN JOURNAL OF HUMAN GENETICS
SN 0002-9297
PD OCT
PY 1995
VL 57
IS 4
SU Suppl. S
BP 1722
EP 1722
UT ISI:A1995RW68701720
ER

PT J
AU TADMOR, OP
ZLOTOGORSKI, Z
GALRONDUNIEC, M
RABINOWITZ, R
NEUMAN, M
BELLER, U
DIAMANT, YZ
TI THE EFFECT OF FEEDBACK ON ANXIETY LEVELS DURING ULTRASOUND SCANNING FOR OVARIAN-CANCER
SO ULTRASOUND IN OBSTETRICS & GYNECOLOGY
AB Women undergoing ultrasound scanning for the detection of ovarian cancer benefit psychologically from the examination, which has been shown to reduce levels of anxiety, depression, hostility and complaints about somatic symptoms. However, it is not completely clear what aspects of the ultrasound examination are responsible for these effects, and how these beneficial psychological effects vary under different circumstances. This study examined, in particular, the effect of various levels of feedback on patients' anxiety levels before and after ultrasound examination.
Two hundred and seven women were randomly assigned to two different experimental conditions: high feedback and low feedback. The subjects' levels of anxiety (both trait and state anxiety) were measured immediately before and after the ultrasound examination. The women's individual risk factors for ovarian cancer were also recorded.
This study showed a significant decrease in the level of trait anxiety following ultrasound scanning. The decrease in anxiety did not relate to the level of feedback provided to the patients, nor to the woman's degree of risk for ovarian cancer. The results are discussed in terms of possible implications for clinical care and the allocation of resources in the medical system.
SN 0960-7692
PD AUG
PY 1995
VL 6
IS 2
BP 135
EP 139
UT ISI:A1995RR87200012
ER

PT J
AU SUTTON, S
SAIDI, G
BICKLER, G
HUNTER, J
TI DOES ROUTINE SCREENING FOR BREAST-CANCER RAISE ANXIETY - RESULTS FROM A 3 WAVE PROSPECTIVE-STUDY IN ENGLAND
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
AB Objective - To investigate whether mammography raises anxiety in routinely screened women who receive a negative result.
Design - Prospective design in which women completed questionnaires at three key points in the breast screening process: at baseline (before being sent their invitation for breast screening), at the screening clinic immediately before or after screening, and at follow up, about nine months after baseline. Information was obtained from non-attenders as well as from attenders.
Setting - Bromelia District Health Authority, served by the South East London Breast Screening Service.
Participants - Two overlapping samples were used. Sample A comprised 1500 women aged 50-64 who were due to be called for first round screening at a mobile screening unit. Altogether 1021 (68%) returned a usable questionnaire and 795 of these (78%) also provided adequate information at nine month follow up: there were 695 attenders (including 24 women who received false positive results) and 100 non-attenders. Sample B consisted of 868 women who attended the screening unit in a three month period, 732 (84%) of whom provided adequate data. A total of 306 attenders (including 10 who received false positive results) occurred in both samples and provided adequate information on all occasions. The main analyses were based on these 306 women plus the 100 nonattenders. The analysis of retrospective anxiety took advantage of the larger sample size of 695 attenders.
Main results - On average, the women were not unduly anxious at any of the three points in the screening process. Among attenders, there was no difference between anxiety levels immediately before and immediately after screening. Anxiety was lowest at the clinic and highest at baseline but the changes were very small in absolute terms. Anxiety did not predict attendance: there were no differences in anxiety levels between attenders and non-attenders at baseline. As expected, women who received false positive results recalled feeling extremely anxious after they had received the referral letter but their retrospective anxiety was also higher than in the negative screenees at earlier stages in the breast screening process. They also reported having experienced more pain and discomfort during the x ray.
Conclusions - Anxiety does not seem to be an important problem in routinely screened women who receive a negative result. This finding is very reassuring in relation to a major criticism of breast screening programmes. Thus, apart from maintaining current procedures such as keeping waiting times to a minimum, there seems to be no need to introduce special anxiety reducing interventions into the national programme. On the other hand, the findings for women who received false positive results suggest that there are aspects of the experience of being recalled for assessment after an abnormal mammogram that warrant further attention. The relationship between contemporaneous and retrospective anxiety should also be studied.
SN 0143-005X
PD AUG
PY 1995
VL 49
IS 4
BP 413
EP 418
UT ISI:A1995RN93600014
ER

PT J
AU TYC, VL
BARCLAY, DR
TI NONPHARMACOLOGIC INTERVENTIONS FOR TREATMENT-RELATED ANXIETY AND DISTRESS IN PEDIATRIC CANCER-PATIENTS
SO INTERNATIONAL JOURNAL OF PEDIATRIC HEMATOLOGY/ONCOLOGY
AB Children with cancer must contend with a number of medical stressors including painful procedures and chemotherapy-induced side effects. Several nonpharmacological/psychological interventions are available to the pediatric cancer patient for the management of treatment-related anxiety and distress. We describe specific methods of intervention used with children and adolescents and the factors affecting treatment effectiveness. We also review, in greater detail, the empirical support for the efficacy of different interventions such as hypnosis, progressive muscle relaxation training, distraction, multicomponent cognitive-behavioral packages, and parent-mediated programs. Particular attention is given to the application of these approaches to the reduction of acute procedural distress, chemotherapy distress, and distress associated with noninvasive procedures. Collectively, the research suggests that nonpharmacological interventions are effective in reducing distress. The implications of these findings and several methodological and practical issues for future research are discussed.
SN 1070-2903
PY 1995
VL 2
IS 3
BP 243
EP 254
UT ISI:A1995RJ13200011
ER

PT J
AU POROCH, D
TI THE EFFECT OF PREPARATORY PATIENT EDUCATION ON THE ANXIETY AND SATISFACTION OF CANCER-PATIENTS RECEIVING RADIATION-THERAPY
SO CANCER NURSING
AB Facing treatment of cancer with radiation therapy causes anxiety for most prospective patients. The purpose of this study was to test the effectiveness of preparatory patient education in reducing anxiety and improving satisfaction during the course of treatment. A quasiexperimental time series design was used to compare two groups of 25 patients, matched according to treatment type and gender, who were commencing radiation therapy for the first time. The experimental group received two structured teaching interventions incorporating sensory and procedural information designed to familiarize the patient with the forthcoming experience. The theoretical basis for the intervention arose from Johnson's work (1973) on preparing patients for threatening events. The control group received the standard information that was current in the Radiation Therapy Department where the study was conducted. The results indicated that the experimental group was significantly less anxious and significantly more satisfied during radiation therapy than their counterparts in the control group, and the effects were maintained throughout the treatment period of up to 7 weeks.
SN 0162-220X
PD JUN
PY 1995
VL 18
IS 3
BP 206
EP 214
UT ISI:A1995QZ94700005
ER

PT J
AU VELIKOVA, G
SELBY, PJ
SNAITH, PR
KIRBY, PG
TI THE RELATIONSHIP OF CANCER PAIN TO ANXIETY
SO PSYCHOTHERAPY AND PSYCHOSOMATICS
AB The interaction between pain and anxiety in the setting of somatic illness is a widely recognised association. More accurate knowledge about the association and also about the means of assessing anxiety in a clinical setting are of use to the clinician. The present study used the Hospital Anxiety and Depression Scale for assessment of anxiety, and the set of linear analogue scales for detecting the presence and severity of anxiety and pain in an oncology clinic, where patients were undergoing active treatment for cancer. The relationship between pain and anxiety was found to be significant, even when the possible mediating effect of the variables of illness severity and age were removed. The need for detecting anxiety in order to plan treatment strategy is emphasised.
SN 0033-3190
PY 1995
VL 63
IS 3-4
BP 181
EP 184
UT ISI:A1995QY56500008
ER

PT J
AU KASH, KM
HOLLAND, JC
MILLER, DG
OSBORNE, MP
TI DOES ANXIETY INTERFERE WITH ADHERENCE TO SCREENING BEHAVIORS IN WOMEN AT GENETIC RISK FOR BREAST-CANCER
SO PSYCHOSOMATICS
SN 0033-3182
PD MAR-APR
PY 1995
VL 36
IS 2
BP 176
EP 176
UT ISI:A1995QJ70900042
ER

PT J
AU MILLAR, K
JELICIC, M
BONKE, B
ASBURY, AJ
TI ASSESSMENT OF PREOPERATIVE ANXIETY - COMPARISON OF MEASURES IN PATIENTS AWAITING SURGERY FOR BREAST-CANCER
SO BRITISH JOURNAL OF ANAESTHESIA
AB We have compared three measurements of anxiety to determine their equivalence in assessing anxiety before surgery. Forty-four patients awaiting breast cancer surgery completed the state scale of the state-trait anxiety inventory (STAI), the hospital anxiety and depression scale (HAD) and a 100-mm visual analogue scale (VAS). Analysis restricted to correlations between the scales gave the misleading impression that VAS scores were inconsistent with those of the HAD and STAI. However, when scores were considered in relation to normative cut-off values to categorize anxiety levels, the three scales showed good agreement. We conclude that the scales were equivalent in their assessment of anxiety before surgery, but that reference to normative data was important in establishing such equivalence and in determining the patient's state.
SN 0007-0912
PD FEB
PY 1995
VL 74
IS 2
BP 180
EP 183
UT ISI:A1995QD91500014
ER

PT J
AU LAMPIC, C
WENNBERG, A
SCHILL, JE
GLIMELIUS, B
BRODIN, O
SJODEN, PO
TI COPING, PSYCHOSOCIAL WELL-BEING AND ANXIETY IN CANCER-PATIENTS AT FOLLOW-UP VISITS
SO ACTA ONCOLOGICA
AB Coping, psychosocial well-being, situation-specific anxiety and cancer-related worry were assessed in 197 consecutive cancer patients attending follow-up visits. Participants completed questionnaires on three occasions: at the follow-up visit, some days later (n = 175) and three weeks later (n = 125). High levels of coping styles 'Anxious Preoccupation' and 'Helplessness/Hopelessness' were associated with low levels of psychosocial well-being, more situation-specific anxiety and more cancer-related worry. High levels of 'Fighting Spirit' and 'Fatalistic' were found to be associated,vith high psychosocial well-being and, for 'Fighting Spirit', also with less cancer-related worry, Patients with a 'dismal' prognosis were found to have higher levels of 'Helplessness/Hopelessness' than patients with a more 'favorable' prognosis. Clinical implications of these findings are discussed.
SN 0284-186X
PY 1994
VL 33
IS 8
BP 887
EP 894
UT ISI:A1994QB69100007
ER

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