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1	循证医学与抗抑郁药 疗效的评价 季建林 教授 复旦大学上海医学院精神卫生学系 复旦大学附属中山医院心理医学科
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18	“4 S” Evolution of Services for Finding Current Best Evidence Computerised decision support systems (CDSS) Evidence-based journal abstracts Cochrane reviews Original published articles in journals
19	BAP 循证指南 英国精神药理学协会 (BAP), 组织权威专家于2000年修订了抗抑郁药治疗抑郁症的循证指南 根据Shekelle的证据分级标准来评估临床证据
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21	Meta-analysis SNRIs SSRIs venlafaxine XL fluoxetine, paroxetine, venlafaxine fluvoxamine Results are based on a meta-analysis of results from over 2000 patients in 8 studies Restricted to only double-blind, randomised, clinical trials Examined at least one of the drugs of interest in at least one research arm, conducted between the years 1994 and 1999 Patients entered for trials must have met the DSM criteria for Major Depression (DSM-III-R) or major depressive disorder (DSM-IV) Drugs were given at therapeutic doses for at least 6 weeks
22	BAP指南:               I级证据表明venlafaxine优于SSRIs 根据 BAP 指南, 已有I级证据表明venlafaxine 疗效可能好于SSRIs 其I级证据来自一项对8篇对照研究的meta-analysis, 结果显示 venlafaxine在治疗中度到重度抑郁症病人方面，彻底缓解抑郁症状的疗效明显好于 fluoxetine 和 paroxetine
23	I级证据：   Venlafaxine XL vs SSRIs                         治疗中度到重度抑郁症病人
24	研究结果 Efexor XL 治疗的病人较SSRIs治疗的病人约多 10% 的机会达到缓解或临床治愈 (45% vs. 35%) Efexor XL 治疗后1-2 weeks 便可出现疗效
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28	不同抗抑郁药临床不良反应率比较