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Onset of antidepressant action: a pharmacological question?(抗抑郁药物起效是一个药理学问题吗?)
目的:本研究有计划地对抗抑郁药物在自然条件下起效问题进行分析。 方法:为多中心,前瞻性,公开的,非对照的自然性研究,入组为582名服用米氮平的门诊病人。病人在研究开始后1,2,4周进行评定,筛选工具为17项汉密尔顿抑郁评定量表(17-HAM-D)和临床总体印象量表(CGI)。根据17-HAM-D分值持续减低大于50%的时间进行传统分析,以评测起效时间。病人被分为4组:极快速有效,快速有效,一般有效,部分有效或无效。治疗1周后应用非参数克(鲁斯卡尔)-瓦(利斯)氏检验法(Kruskall-Wallis analysis)评估群组间和逻辑回归差异,预测是否有效...

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What Are the Right Targets for Psychopharmacology
POLICY FORUM Conventional wisdom demands that those to would make medic ine&— whether in a pharmaceutical compaiw or clinical department—have a validated drug target. Ideally. this is a drug-modifiable protein or nucleic acid that is either directly involved in or able to mod ifv the pathophysiolog
Separation of anxiety and depressive disorders-blind alley in psychopharmacology and classification of disease
Downloaded from bmj.wm on 11 October 2007 BvIJ Separation of anxiety and depressive disorders: blind alley in psychopharmacology and classification of disease Edward Shorter and Peter Tyrer BMJ 2003:327:158-160 doi:10.1 136)bmj.327.7407.158 Updated information and services can be found at: ht
Psychopharmacology for Young Children Clinical Needs and Research Opportunities
PEDIATRICS? FOf FICIAL JOURNAL OF THE AMERICAN ACADEMY Of PEDIATRICi7 PsclHipl1arniacnlogv hir ‘oun Children: Clinical %ced% 1I1(I Research opportunities Benedetto Vitiello Pediatrics 2001 1 08;983-989 DOl: 10.1 542/peds. 108.4.983 The online version of this article, along with updated inform
Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder
D,rss, AND 4iirir 0:1-12 2007, Resea i rh Rev jew NORADRENERGIC DYSFUNCTION AND THE PSYCHOPHARMACOLOGY oF POSTTRAUMATIC STRESS DISORDER J. R. Strawn, M.D. and T. [). Oeracioti,Jr, M.D.'2 The catechokrn,i,,e norepinephriiie is a critical effector of the n:am,,,alian stress response and has been
Neurotransmitter transporters and their impact on the development of psychopharmacology
British Journal of Pharmacology (2006) 147, S82 S88 C 2006 NatjrePjbli'iGrot A rr1sreser0007-118&06S30.00 *w. atre.cornibjp Neiirotransmitter transporters and their impact on the (levelOpifleIlt ot psychopharnacoIogy *[,csIic I crseii Departnnt of Pharmacology, University of Oxford, Mansfield
Enantiomers' potential in psychopharmacology-a critical analysis with special emphasis on the antidepressant escitalopram
L £LSVIER European Ncuropsvchopharniacoloty 12 (2002) 433—444 IUROPW NEUROPSYCHOPHARMACOLOGY www.elsevier.com,' locate,' euroncuro Enantiomers' potential in psychopharmacology—a critical analysis with special emphasis on the antidepressant escitalopram* Pierre Baumann*. Daniele F. Zullino, Ch

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