【著者Authors】 Cankurtaran ES, Ozalp E, Soygur H, Akbiyik DI, Turhan L, Alkis N
【来源Source】 Support Care Cancer. 2008 Feb 26
【关键词Keywords】 Mirtazapine,cancer patients
【摘要Abstract】
癌症病人除本身疾病带来的症状外，还存在呕吐 、疼痛、 睡眠障碍，食欲不佳等症状，并且大多数患者有焦虑抑郁症状，本研究关注米氮平与丙咪嗪改善这些症状的疗效比较……
GOALS OF THE WORK: This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms.
MATERIALS AND METHODS: Fifty-three patients with cancer who were diagnosed with major depressive disorder, anxiety disorder, or adjustment disorder were included. Twenty patients on mirtazapine, 13 patients on imipramine, and 20 patients in the control group without medication were interviewed during three visits (baseline, third week, and sixth week). Pain, nausea, vomiting, appetite loss, and sleep disturbances were evaluated with self-assessment single-symptom scales during each visit. The patients were also asked to complete the Hospital Anxiety Depression Scale (HADS) during each visit.
MAIN RESULTS: There were no significant differences among the three visits in the mirtazapine, imipramine, or control groups in terms of pain, nausea, vomiting, or appetite loss. For the initial, middle, and late insomnia, only the mirtazapine group showed improvements (p = 0.001, p = 0.001, p = 0.003). There were also significant differences in the mean total (p = 0.03), anxiety (p = 0.003), and depression (p = 0.025) scores of HADS among the three visits for patients taking mirtazapine. There were no significant differences for HADS scores from the baseline to the end point for patients taking imipramine or control group patients.
CONCLUSION: Our findings suggest that mirtazapine is effective for resolving insomnia as well as anxiety and depressive symptoms in cancer patients. However, more systematic research, such as placebo-controlled studies, is needed.
